Nicolas Cornelissen

Scheme of the chemo-enzymatic synthesis of modified nucleoside-5´-triphosphates as mRNA building blocks.

Join us as the first PhD student in my group! Based in the beautiful city of Münster, Germany, you will develop the chemo-enzymatic synthesis of modified nucleotides, which are used as building blocks of mRNA.
Here is the link:
stellen.uni-muenster.de/jobposting/6...

#chemsky #chembio

Again thanks for highlighting, but the text refers to a completely different paper. We engineered a polyphosphate kinase to produce base-modified GTP and ATP analogues!

Thanks to Rachel, @raschere.bsky.social, Ann-Marie, Jannik, Aileen, @rentmeisterlab.bsky.social and Daniel!

We determined the first crystal structure of the polyphosphate kinase 2 class III from Erysipelotrichaceae bacterium and used structure-guided engineering to enable efficient access to nucleobase-modified GTP and ATP analogues.

We systematically studied the substrate preferences of EbPPK2, determined the first crystal structure of the enzyme and used structure-guided engineering to enable efficient access to base-modified GTP and ATP analogues. #ChemSky #ChemBio

pubs.rsc.org/en/content/a...

Research Position (PhD) in organic chemistry and b... <div style="text-align: justify;">The&nbsp; research&nbsp; group&nbsp; „Organic&nbsp; Chemistry&nbsp; and&nb...

Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)

Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group

uni-bielefeld.hr4you.org/job/view/433...

A baby platypus is called a puggle (or 'platypup' 😁)

And anytime you post a video like this one, someone always points out they have venomous spurs.

The adult males DO, but *only* the adult males!

Let's talk about the amazing venom cocktail produced by this adorable little beaver-duck.

Praia de Carcavelos

Praia da Torre

Holidays with the family in and around Lisbon, where I lived for eight years 🎉🎉🎉

This would be a an option.

A chimeric cofactor is used to turn methyltransferases into prenyltransferases.

With chimeric cofactors, we can turn methyltransferases into prenyltransferases. Methyltransferases even prefer AdoPrenyl!Thanks to co-first author Arne and the team led by Andrea
@rentmeisterlab.bsky.social #ChemSky #ChemBio
Read the full story in CHEM www.cell.com/chem/fulltex...

Exogenous RNA surveillance by proton-sensing TRIM25 Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

Last Saturday morning ☕ saved for this gem:

www.science.org/doi/10.1126/...

CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.

Wir können gerade live zuschauen, wie die rechte Regierung in den USA die Wissenschaftslandschaft zestört. Bitte wählt demokratisch! #chemsky #ChemBio

Sophie Scholl, Hans Scholl und Christoph Probst

"So ein herrlicher Tag, und ich soll gehen. Aber was liegt an unserem Leben, wenn wir es damit schaffen, Tausende von Menschen aufzurütteln und wachzurütteln" (Sophie Scholl)

Heute vor 82 Jahren wurden Sophie Scholl, Hans Scholl und Christoph Probst von den Nazis ermordet.

Just a reminder that Germany was the center of scientific progress until the Nazis suppressed, drove away, or killed all the non-Nazi scientists.

The ACS has deleted its website on Diversity, Equity, Inclusion & Respect. And with that move, have shown they are worthy of none of the latter.
People ask why no-one stands up to fascists, this is why - they are too worried about their own standing to challenge it.
www.acs.org/about/divers...

This is bad...

Science’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access

🧪Science breakthrough of the year - a mindblowing example of the value of interdisciplinary approaches and a testament to the value of fundamental research:

From understanding HIV capsid architecture to a drug that may soon eradicate the disease! 🤯🤯🤯

www.science.org/content/arti...
@science.org

We tested the ability of a SAM riboswitch to detect 17 in situ generated SAM analogues. Just accepted in ChemComm! Thanks to my former colleagues Jonas, Aileen and Arne in the Rentmeister Lab and especially to Andrea for her constant support. #ChemSky #ChemBio
pubs.rsc.org/en/content/a...

The picture shows the chemo-enzymatic synthesis of base-modified ATP analogues. These compounds can be used to generate hypermodified poly(A) tails.

In July, I published my first paper on the chemo-enzymatic generation of base-modified ATP analogues! These can then be used to generate hypermodified poly(A) tails. Thanks to all the people involved!
pubs.rsc.org/en/content/a...

Labore am Institut für Biochemie der Uni Münster

W2-Professur für Molekulare Biochemie an der Uni Münster!
Bewerbung bis zum 15.03.2024
www.uni-muenster.de/Rektorat/Ste...

Ok, so if you’re an organic chemist you’ve done chiral GC-MS. What if you could drop the GC, and just measure enantiomeric ratio by MS? That’s what’s in SCIENCE today from Xiaoyu Zhou and coworkers in Zheng Ouyang’s group. Have a look:

Chemsky 🧪

www.science.org/doi/10.1126/...

Thanks Pavel!

Hi Bluesky,
over the last years I was working on the biocatalytic generation of SAM analogues to expand the scope of methyltransferases. Selective 4-chlorobenzylation on the mRNA 5′ cap could improve protein production in human cell lines.
doi.org/10.1039/D3SC...