Jerry C

Time projection images of mast cells (RBL-2H3) expressing active mutant of formin mDia3, captured by TIRFM.

The softcopy version of my submission!

Realized this morning that my submission got selected for Yale's Beauty in Science 2025 exhibition! Seeing the live-assembly of filopodia projections by formin mDia3 in mast cells got me really stoked back then! #FluorescenceFriday

🧵5/6 — The Big Picture
EndoNB works on endogenous proteins. No rare antibodies. No overexpression.
It’s scalable and ready to explore the 1000+ surface proteins we’ve barely studied.
We’re done understanding vesicular trafficking by looking at a handful of model surface proteins.

🧵1/6 — Preprint Alert!
I am super proud to present the latest work of our lab. Earthlings and those just visiting, I introduce you…. EndoNB: A better, smarter and versatile way to study the dynamics of cell surface proteins. 🧪
www.biorxiv.org/content/10.1...

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

We show that under low ahesion conditions Tensin 1 forms endogenous condensates to store inactive adhesion components. These can be released upon stress-mediated Tensin 1 phosphorylation to regulate adhesion dynamics.

Adhesion-derived condensates control component availability to regulate adhesion dynamics Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...

This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social

Adhesion-derived condensates control component availability to regulate adhesion dynamics Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...

New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social

Unlike eggs & mitotic cells, in adherent interphasic cells the centrosome is NOT positioned by a balance of forces along #microtubules, but by cell shape organization around the #centrosome: rupress.org/jcb/article/...
@lblanchoin.bsky.social
@manuelthery.bsky.social
@gelinmatthieu.bsky.social

Progress on the quest for a red mStayGold!
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...

Incredible 4Pi and pan-expansion imaging of the Golgi 👇

Thanks for selecting my entry. This is one of my favorite movies captured. I’m very flattered 🙂

Hi everyone, because it's my first time winning any contest, I ain't gonna lose this wave of opportunity to talk about it 👀. I got tweeted, but I feel the need to publicize this here too. I won the @ascbiology.bsky.social ASCB 2024 Image Contest! Thanks for selecting my entry!

Jerry with his prop to showcase waves

Jerry laughing at all the good questions and grilling

It was a humbling experience being able to talk to people about our works at the ASCB. I’m flattered that I had plenty audience for me to keep going without break for ~6 h straight and going overtime! Thanks, everyone 🥹 #CellBio2024 @ascbiology.bsky.social

#FluorescenceFriday An old video of a cute mast cell (RBL-2H3) exhibiting cortical waves of active Cdc42 after getting treated with cytochalasin-D overnight. Sorry not sorry to kill #actin hehe. #TIRF 4 s per frame acquisition, 8 fps, 32× real time.

I’ve been using cloudconvert.com/avi-to-mp4 to convert video formats heh. It allows you to adjust the resolution, codecs etc, if this is something you are looking for?

I will be representing @wumin-lab.bsky.social group to present our recent work at ASCB, on Monday Dec 16th, 11:15 AM! Board Number B19, P1714. Come have a chat! I'd probably also be dropping teasers on where our follow-up study is heading 😎

Look at these distinct clusters exhibited by N-WASP and Arp2/3 ! Is branched #actin polymerization the sole driving force for nucleating cortical actin waves? Cross-talks within the actin network can be messy, so how can we study such complexities? #CellBio2024 @ascbiology.bsky.social

Mix two motors of opposite polarity with microtubules and they will partition space !
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)

Before I start posting about newer results on this platform, here is a video from our most recent paper -- www.nature.com/articles/s41...

If you're searching for the Mechanobiology community and starter pack, here it is:

Thought this would be a great opportunity to gather the #mechanobiology community. Please feel free to spread the word.
go.bsky.app/G5cQqYT

here's the starter pack for cytoskeleton
go.bsky.app/TF83cpi

A still from a cine film down a microscope showing dark patches in two cells that are recognisable to a cell biologist nowadays as focal adhesions. The view is through the eyepieces i.e. circular, as though we are spying on the cells.

Who needs immunofluorescence?

Focal adhesions (or cell feet as they were known then) were first observed in this 1975 paper by Abercombie and Dunn
doi.org/10.1016/0014...

This gem comes from the obituary of Graham Dunn published in J Cell Sci today.
doi.org/10.1242/jcs.... 🧪

I started a list of people working broadly on cell adhesion and cell migration. I likely missed many, please drop me a message if you want to be added

go.bsky.app/5Gzo7oZ