Raiees Andrabi

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift Identifying and understanding the molecular basis of conserved spike epitopes targeted by broadly neutralizing antibodies (bnAbs) are key for developing broad coronavirus vaccine design. Song et al. r...

In our new study, we show that several pre-Omicron RBD bnAbs still neutralize highly mutated SARS-CoV-2 variants. Structures reveal conserved, vaccine-targetable epitopes that resist extreme antigenic drift, highlighting promising targets for pan-sarbecovirus vaccines www.cell.com/cell-reports...

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization Current vaccine strategies to elicit broadly neutralizing antibodies (bnAbs) against HIV-1 generally propose complex, multi-boost immunization regimens. In rhesus macaques, SHIV infection has been obs...

A fantastic collaborative effort with the BatistaLab (Ragon/Harvard), ShawLab(Penn) and IrvineLab (Scripps) where we show how targeted immunogen design can induce HIV broadly neutralizing antibody responses! www.biorxiv.org/content/10.1...