Sjoerd van Wijk

Opening a "Decision on your Manuscript" email

Join us at the 28th Meeting on Signal Transduction - CellCommSummit 2025 from November 3 - 5 2025 in Weimar, Germany, with a great line-up of speakers!!! 🔥 🔥 🔥

Apply for short talks, science prizes and travel stipends!!!

Great for networking, from Master students to groupleaders!!!

Das ist Trumpisch, um es politisch zu sagen. Das ist Wissenschaftsfeindlichkeit im dünnen moralisierenden Mäntelchen. Und, das ist toxische Weiblichkeit im Amt: Andere Frauen schmähen, sie als nicht hinreichend hart schmähen, sich selber damit andienen an phantasmatische "Männlichkeit"....

sowie die Wissenschaft selbst hiervon abzugrenzen, davor zu schützen und solchen politischen Dreck in die Schranken zu weisen. Das ist enorm beunruhigend, was D. Bär hier abzieht. In aller Öffentlichkeit und ganz bestimmt in Abstimmung mit Merz et al. ...

unsinnigen Behauptungen operiert hat, nicht zuletzt mit den raunenden Andeutungen eines selbst verurteilten & dubiosen 'Plagiatsjäger'. Das kann man alles politisch machen, meinetwegen. Aber als Wissenschaftsministerin hat man die verdammte Pflicht, Wissenschaftlerinnen und Wissenschaftler ...

Bär hätte qua Amt die Integrität und (Teil-)Autonomie der Wissenschaft sowie der Rechtsprofessorin Brosius-Gersdorf zu betonen sowie zu schützen. Es ist inzwischen hinlänglich dokumentiert, dass die Kampagne massiv mit fake news, irren Verzerrungen...

Wahl der Verfassungsrichter: Brosius-Gersdorf berichtet von Drohungen nach gescheiterter Wahl Aufgrund von Drohungen hat Frauke Brosius-Gersdorf ihre Mitarbeiter gebeten, nicht am Lehrstuhl zu arbeiten. Einen Verzicht auf ihre Kandidatur schließt sie nicht aus.

Wissenschaftsministerin ein massiver fail. Ideologisch, dumm, und in der Sache so falsch wie im Amt unprofessionell. Anstatt sachlich nüchtern die Professorin vor Diffamierungen & gegen 1 Kampagne zu schützen, wirft sie diese erneut dem geifernden Polit-Mob zum Fraß hin.
www.zeit.de/politik/deut...

Also, so langsam wäre man dann ja schon bereit für eine kompetente Leitung des Bundesforschungsministeriums …

Wahl der Verfassungsrichter: Brosius-Gersdorf berichtet von Drohungen nach gescheiterter Wahl Aufgrund von Drohungen hat Frauke Brosius-Gersdorf ihre Mitarbeiter gebeten, nicht am Lehrstuhl zu arbeiten. Einen Verzicht auf ihre Kandidatur schließt sie nicht aus.

Eigentlich sollte eine Wissenschaftsministerin Stimme der Wissenschaft im politischen System sein.
Bär will hingegen was anderes sein und fordert von Wissenschaftlerinnen "Kritikfähigkeit" ein, wenn sie diffamiert werden.

www.zeit.de/politik/deut...

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

Our latest work:
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis: Cell www.cell.com/cell/fulltex...

I was today years old when I first heard this gorgeous quote at #EMBOclimateResilience: “The way in which our universities have divided up our sciences does not reflect the way in which nature has divided up its problems” (Kurt Salzinger) - thank you @luciastrader.bsky.social!

It was great being in Cologne! Meeting many new people and seeing many known faces, thanks for the invitation Christina Ising @cecad.bsky.social

Keukenhof, Netherlands 🇳🇱
#photography

Honored and looking forward to talk tomorrow at the Cologne Cell Death Club of the #sfb1403 at the University of Cologne #CECAD

Comparison of Salmonella and Shigella host cell invasion. Salmonella are targeted by the host E3 ligase RNF213, which ubiquitylates bacterial lipopolysaccharide (LPS), marking bacteria for autophagic destruction. Shigella employs its effector proteins IpaH1.4 - an E3 ubiquitin ligase itself - to ubiquitylate RNF213, leading to its proteasomal degradation and thus preventing the host from tagging Shigella for destruction.

Cryo-EM structure showing how the leucine-rich repeat (LRR) domain of IpaH1.4 binds to the RING domain of RNF213

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery?

@felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities.
Read more: tinyurl.com/3y4kv2bp

#LMBResearch🧪

The Biochemical Society 2026 Awards. Early Career Research Award: Dr Georgia Atkin-Smith. WEHI, Australia

We are delighted to announce 4 Early Career Research Awards for 2026! Firstly, congratulations to Georgia Atkin-Smith who is internationally recognised throughout the cell death community for high-calibre landmark discoveries in the field of cell death and biology @someblondesci.bsky.social

Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system | The EMBO Journal imageimageInterferon induces the formation of ADP-ribosylation (ADPr)-enriched p62 bodies, requiring PARP14 and p62. Unlike canonical p62 bodies, these ADPr-enriched structures are independent of auto...

🥳 Out now @embojournal.org!
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....

UbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains Ubiquitin chains determine the fates of their modified proteins, including proteasomal degradation. Kiss et al. present UbiREAD, a technology to monitor cellular degradation and deubiquitination at hi...

Super excited to share our latest work on deciphering the #Ubiquitin Code

“𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀”

@cp-molcell.bsky.social

1/8

www.cell.com/molecular-ce...

Already some time ago, but happy to share our contribution to BIOspektrum!!!
rdcu.be/eeEtZ
link.springer.com/article/10.1...

Illustration: Eine kleine gehörnte Kreatur steht zwischen den personifizierten Gehirn und Herz und fragt, ob sie einander kennen

Die uralte Frage 🧠🤝❤️

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

Lung sections from mice infected with mouse-adapted SARS-CoV-2 variants stained for viral nucleoprotein. MA10 and beta variants show diffuse staining patterns throughout the lung while omicron infection results in infection that is mostly restrained to the large airways.

🚨Our new preprint! IFITM3 KO mice accelerated SARS-CoV-2 Beta & Omicron adaptation, preserving human-relevant traits & enabling comparative pathology/transcriptomics in mice. 🫁🦠🧬🥼 With @parkerjdenz.bsky.social, @adforu.bsky.social & team. 🔗 www.biorxiv.org/content/10.1...

Should I be proud or worried? This is the first time that one of my tweet makes it into the news.

www.researchprofessionalnews.com/rr-news-usa-...

A temperature-inducible protein module for control of mammalian cell fate - Nature Methods The Melt (Membrane localization using temperature) protein translocates to the plasma membrane upon temperature shift. Melt variants with a range of switching temperatures enable straightforward therm...

Every once in a while we publish a paper that moves a whole field forward. I think that's the case for this one from the Bugaj lab, where they describe proteins for THERMOGENETIC control of cellular behavior. www.nature.com/articles/s41...

Really sorry to hear that, will cross my fingers!

Weidel gegen Wagenknecht bei Maischberger: Die Latte immer tiefer legen Weidel gegen Wagenknecht reloaded: In der Talkshow von Sandra Maischberger umwarb die AfD-Chefin die CDU, nannte Hitler einen Kommunisten und fühlte sich in der Rolle der Stärkeren pudelwohl.

»Jeder Tag bringt neuen Bullshit, der uns um den Verstand bringen müsste, und trotzdem muss man sich jeden Morgen die Zähne putzen, zur Arbeit gehen und so tun, als wäre die Welt noch wiedererkennbar.«

FAZ 🎯

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring | Science | AAAS www.science.org/content/arti...

Trump administration directs federal health agencies to pause communications | CNN Amid a deluge of executive actions, the Trump administration has directed federal health agencies to pause external communications, such as regular scientific reports, updates to websites and health a...

amp.cnn.com/cnn/2025/01/...

Alarming...

A world less safe and secure On 20 January, President Trump announced the withdrawal of the United States from the World Health Organization (WHO). President Trump shares many of the same concerns about WHO as previous administra...

New in @science.org: A World Less Safe & Secure
We examine how the US withdrawal from @who.int will limit US leadership to protect public health & challenge WHO governance in facing global challenges.
www.science.org/doi/10.1126/...