bedzhov lab

Cellular Interfaces reloaded: Join us for the @sfb1348.bsky.social International Meeting on „Mechanochemical signals at cellular interfaces" in Münster from May 27–29, 2026.
Registration opens in February! Limited spots – first come, first serve! More info: tinyurl.com/ypyzd23w
@uni-muenster.de

Developmental regulation of Erk signaling by mitotic kinases
doi.org/10.1126/scia...

Developmental regulation of Erk signaling by mitotic kinases The mitotic kinases aurora A and polo-like kinase 1 act as cell-intrinsic regulators of Erk signaling in pluripotent stem cells.

We found that in addition to Fgf/Mek, Erk is activated by Aurora kinase A to promote differentiation. During cell division, Erk localizes at the centrosomes, where its activation depends on Plk1.

Congrats to Fei & the team!

doi.org/10.1126/scia...
🐁 @sfb1348.bsky.social @mpi-muenster.bsky.social

Thank you, Leo!! ☺️

This is our Tron-inspired candidate cover design for Dev Cell, illustrating the temporal sequence of epithelial morphogenesis during preimplantation development.
Although the image was not selected for the cover, we enjoyed developing the concept.
t.co/XQ43VeLSR0

We found a new function of the core pluripotency transcription factors Oct4 and Sox2 in the early embryo!

Check out our paper: doi.org/10.1016/j.de...

Congratulations to Deepthi and the rest of the team!
🐁

Thank you, Allison! ☺️♥️ This is very kind of you.

 Figure 2: Selected signalling, metabolic and morphogenetic responses in the diapausing mouse embryo. Nutrient deprivation, suppression of the mammalian target of rapamycin complex 1 (mTORC1) or Myc activity can trigger dormancy response in mouse embryos. Diapausing embryos activate the leukemia inhibitory factor/signal transducer and activator of transcription 3/transcription factor CP2-like protein 1 (LifR/STAT3/Tfcp2l1) pathway and increase their dependency on fatty acid oxidation. During the first 3 days of diapause between E4.5 and estimated day of gestation (EDG) 7.5, the number of cells gradually increases and canonical Wnt signalling is temporarily activated. After EDG7.5, Wnt activity is downregulated, the epiblast undergoes epithelialisation and Yap translocates to the nucleus, governing the survival and reactivation capacity of the pluripotent lineage. The three background colours indicate dormant (grey), quiet (light yellow) and active (dark yellow) metabolic states.

Pause and play: insights into mammalian embryonic diapause

In this Spotlight, Rui Cehn and Ivan Bedzhov (@bedzhovlab.bsky.social) from @mpi-muenster.bsky.social discuss the emerging mechanisms that govern mammalian embryonic diapause.

doi.org/10.1242/dev....

Check out our Spotlight article, which outlines the metabolic states during early development, focusing on embryonic diapause.
🐁
doi.org/10.1242/dev....

Congratulations to Deepthi for successfully defending her PhD thesis! 🎉

“Implantation is the most difficult and unpredictable stage,” wrote IVF pioneer Sir Robert Edwards.
In this review, we explore the cell shape and tissue dynamics in the early mouse embryo, focusing on the peri-implantation stages of development and embryonic dormancy.🐁

doi.org/10.1016/bs.c...

Our lab turns 10! 🎂🎉
Huge thanks to everyone who’s been part of our journey! ♥️

Looking forward to an exciting seminar with Leo Kurian @kurianlab.bsky.social @goetheuni.bsky.social on Sept 11. He will speak about
#RNA regulatory principles of engineering fate in living systems
More info: www.uni-muenster.de/SFB1348/en
Everyone's welcome! @sfb1348.bsky.social @uni-muenster.de

Cellular dynamics in the dormant embryo
(highlights of Rui Chen's work on embryo dormancy)

www.biospektrum.de/system/files...

Proud to kick-off #HetCCI, a DFG-funded research consortium in Germany (Priority Programme #SPP2493 on heterotypic cell-cell interactions in epithelia). Follow us if interested in how epithelial cells interact with non-epithelial tissues in different settings! Webpage will follow asap. #cellbiology

Thanks, Leo! ☺️

GSCN Stem Cell Club is on 5 July with I. Bedzhov and M. Kraushar at 16:15 - join the lectures & discussion at 16:15. Find link & info: gscn.org
#stemcells #regeneration #developmentalbiology #stammzellen @mdc-berlin.bsky.social sky.social @dkfz.bsky.social @maxplanck.de @bihatcharite.bsky.social

Protocol for 3D In Vitro Culture of Early Mouse Embryos and Trophoblast Tissue Explants
link.springer.com/protocol/10....

Congratulations to Devila, Shashank and Nirai, and thanks to Adrian for his instrumental support @adrianranga.bsky.social

@mpi-muenster.bsky.social @sfb1348.bsky.social

Thank you, Teresa!! ☺️

the MPI band Heizzentrale, live, Friday 23rd 🤘🤘
@MPI Münster

Step-by-step protocol for induction, maintenance, and exit from embryo dormancy in mice
doi.org/10.1016/j.xp...

Congrats to Rui Chen and Rui Fan!

Ufuk Günesdogan (University of Göttingen) will speak about “Transcriptional and Epigenetic Programming of Human Primordial Germ Cells”.
The seminar will take place in the MIC lecture hall (Röntgenstr. 16, Münster), on Thursday, 3rd of April at 5:15.

@guenesdoganlab.bsky.social
@sfb1348.bsky.social

Congratulations, Stefan to you and your team! Fantastic work, beautifully illustrated!

Congrats to Fei Chen for successfully defending her PhD thesis! 👩‍🎓

Max Planck Postdoc Program Launching in April 2025, the Max Planck Postdoc Program features structured application calls and a comprehensive support system for researchers.

Max Planck Postdoc Program www.mpg.de/en/max-planc...

There's an 🤩 impressive lineup of speakers for this event:
🇸🇪🇦🇹 @adameykolab.bsky.social
🇩🇪 @bedzhovlab.bsky.social
🇺🇸 @crumplab.bsky.social
🇩🇪 @anne-grapin.bsky.social
🇫🇷 @pasteur.fr
🇨🇭 @lanevol.bsky.social
🇪🇸 @jamesasharpe.bsky.social
❤️ home country discussing #science! JOIN US ✨!

We have an exciting line-up of speakers for our @sfb1348.bsky.social meeting "Cellular Interfaces across Scales: from Molecules to Tissue Dynamics" from May 7 - 9, 2025. Registration will start on February 1, 2025. More information: crc1348-conference.ycode.site

exhibition inVISIBLE
at the foyer of the Multiscale Imaging Centre, Münster
uni.ms/inVISIBLE

Cantas Alev (Kyoto University) will give an exciting
@sfb1348.bsky.social lecture about “Towards reconstituting human and primate early embryonic development in vitro” today at 5:15 pm. Everyone is welcome! More: www.uni-muenster.de/SFB1348/en/i...

Wishing you a wonderful holiday season! ❄️