Laurence Pearl πŸ”₯'s Avatar

Laurence Pearl πŸ”₯

@laurencepearl.bsky.social

Has-been structural biologist FRS (no really) reinventing himself as a computational cancer geneticist in the post-AlphaFold world. Hooked on boats. Picture - outside Leonard Cohen's house on Hydra after sailing there. ORCID 0000-0002-6910-1809

2,076 Followers  |  752 Following  |  2,326 Posts  |  Joined: 23.09.2023  |  2.0117

Latest posts by laurencepearl.bsky.social on Bluesky

SWP is very much the bindweed of British left politics.

02.12.2025 09:50 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

And very relaxed about their leadership sexually abusing women members

02.12.2025 09:49 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I used to have a friend who was in the SWP.

This is (apart from the bit about the internet) exactly what he believed.

It's actually a deeply patronising, very middle-class, very rose tinted student-Marxist view of working people that is completely divorced from any experience of life.

02.12.2025 08:34 β€” πŸ‘ 161    πŸ” 22    πŸ’¬ 42    πŸ“Œ 2

You see this stuff and you think to yourself β€œwhy does no politician in Britain want to copy the proven German model of having union representation in the boardroom?”

Instead we still have this failed East German ideology still being trotted out by the Crank Left.

02.12.2025 08:45 β€” πŸ‘ 12    πŸ” 1    πŸ’¬ 2    πŸ“Œ 0

When even Owen Jones looks like he's struggling to keep a straight face you might have gone too far left.

02.12.2025 06:51 β€” πŸ‘ 21    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Seize the memes of production

02.12.2025 06:37 β€” πŸ‘ 130    πŸ” 3    πŸ’¬ 4    πŸ“Œ 0

No. It’s little girl in her bedroom lecturing an assortment of dolls and teddies level

02.12.2025 06:41 β€” πŸ‘ 41    πŸ” 2    πŸ’¬ 3    πŸ“Œ 1
chart of child mortality in history, roughly 48% for all societies across the globe…until the 20th century, where it plummets to 4%

chart of child mortality in history, roughly 48% for all societies across the globe…until the 20th century, where it plummets to 4%

Currently dorking out over this graph about child mortality with my brother. Just mind boggling to take in.

02.12.2025 05:00 β€” πŸ‘ 1378    πŸ” 543    πŸ’¬ 40    πŸ“Œ 88
A mugshot registration photograph from Auschwitz. A woman wearing a striped uniform photographed in three positions (profile and front with a bare head and a photo with a slightly turned head with a headscarf on). The prisoner number is visible on a marking board on the left.

A mugshot registration photograph from Auschwitz. A woman wearing a striped uniform photographed in three positions (profile and front with a bare head and a photo with a slightly turned head with a headscarf on). The prisoner number is visible on a marking board on the left.

2 December 1889 | A Polish woman, Maria Mnich, was born in Udrycze.

In #Auschwitz from 13 December 1942.
No. 26973
She perished in the camp on 21 April 1943.
---

Women at Auschwitz

Lesson: https://lekcja.auschwitz.org/2022_kobiety_en/
Podcast: https://youtu.be/ijTxtbNlJO8

02.12.2025 09:00 β€” πŸ‘ 278    πŸ” 45    πŸ’¬ 4    πŸ“Œ 1

Thank science.
All to be undone by ignorant politicians...

02.12.2025 09:00 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Nobody who ever visited Soviet Eastern Europe would advocate such a stupid idea.

02.12.2025 09:41 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

You never know where a good idea is going to come from!

Inspiration struck Prof Michael Baum on new ways of thinking about #BreastCancer treatment while watching a production of Arcadia by the late Tom Stoppard

Thanks to @harrywallop.co.uk for sharing this from the @thetimes.com

#CanSky #OncoSky

02.12.2025 09:35 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
Genome Damage and Stability Centre : University of Sussex

The new website for the world renowned Genome Damage and Stability Centre at Sussex is now up and running. Enjoy -
www.sussex.ac.uk/research/cen...

02.12.2025 09:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Black and white portrait of a woman with a calm expression, wearing a dark blouse and hair styled in an updo.

Black and white portrait of a woman with a calm expression, wearing a dark blouse and hair styled in an updo.

A vintage black and white photo of a young girl standing in front of a wooden fence with lush foliage in the background. She is wearing a dress and a bow in their hair, and is smiling at the camera.

A vintage black and white photo of a young girl standing in front of a wooden fence with lush foliage in the background. She is wearing a dress and a bow in their hair, and is smiling at the camera.

1 December 1942 | A transport of 532 Norwegian Jews deported from Bergen arrived at #Auschwitz. SS doctors sent 186 men to be registered in the camp. The remaining 346 people were murdered in a gas chamber.

Among them were Olga Wulff and her daughter Doris.

01.12.2025 13:00 β€” πŸ‘ 350    πŸ” 103    πŸ’¬ 5    πŸ“Œ 3

Read this, in honor of a theatrical genius and one of their inspirations

01.12.2025 01:41 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
Preview
David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

The world has lost a giant of virology, molecular biology and science advocacy

David Baltimore’s obituary by Stephen Goff www.nature.com/articles/d41...

01.12.2025 13:25 β€” πŸ‘ 26    πŸ” 17    πŸ’¬ 0    πŸ“Œ 0

Any protein crystallographer will tell you that almost any concentrated pure protein in isolation in a simple buffer can be made to phase separate in vitro. It’s an artefact.

01.12.2025 08:30 β€” πŸ‘ 11    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Not mixed up by anyone who actually knows anything about protein biochemistry

01.12.2025 08:16 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

liquid-like or gel-like molecular organization does not mean it is formed through LLPS. The phenomenon and the mechanism have been often mixed up in the scientific community and literature.

01.12.2025 08:06 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 3    πŸ“Œ 0

The best analogy is traffic on a motorway. Viewed on the average, traffic β€˜macroscopically’ behaves like a viscous liquid, but only an idiot - or apparently the editor of a journal - would think that means that cars β€˜microscopically’ are driven by fluid mechanics

01.12.2025 08:15 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Only in the same way that a flat earth and Kepler’s Laws are not mutually exclusive

01.12.2025 08:08 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

If it can be disrupted by a point mutation in a residue mediating a stereospecific PPI - ITS NOT LLPS - ITS REAL BIOCHEMISTRY FFS.

30.11.2025 22:53 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Aargh

30.11.2025 22:50 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Orange picture with a line drawing of a horses face on a man’s upper body showing a part of a jacket and glimpse of a man’s face. Also a large red blob middle right.

Orange picture with a line drawing of a horses face on a man’s upper body showing a part of a jacket and glimpse of a man’s face. Also a large red blob middle right.

Marc Chagall just popping by to wish you a happy Sunday morning.

30.11.2025 09:25 β€” πŸ‘ 92    πŸ” 11    πŸ’¬ 6    πŸ“Œ 0
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🫣

#LLPS #Droplets #phaseseparation

30.11.2025 08:57 β€” πŸ‘ 67    πŸ” 8    πŸ’¬ 4    πŸ“Œ 1
A mugshot registration photograph from Auschwitz. A man with a shaved head wearing a striped uniform photographed in three positions (profile and front with bare head and a photo with a slightly turned head with a hat on). The prisoner number is visible on a marking board on the left.

A mugshot registration photograph from Auschwitz. A man with a shaved head wearing a striped uniform photographed in three positions (profile and front with bare head and a photo with a slightly turned head with a hat on). The prisoner number is visible on a marking board on the left.

30 November 1892 | A Pole, Jan Guzik, was born in BoguchwaΕ‚a. A gardener.

In #Auschwitz from 13 April 1942.
No. 29546
He perished in the camp on 30 June 1942.
---

"Poles at KL Auschwitz”: http://lekcja.auschwitz.org/en_2020_06_polacy/

30.11.2025 09:00 β€” πŸ‘ 380    πŸ” 72    πŸ’¬ 9    πŸ“Œ 1

I couldn’t possibly comment

30.11.2025 08:34 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Post image

Looks like we're for it again at Christmas. Twice.

30.11.2025 05:16 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Several newspapers are mourning the death of "Shakespeare in Love screenwriter Tom Stoppard" which, while technically true, is very much on the level of "Thomas The Tank Engine narrator Ringo Starr".

29.11.2025 21:42 β€” πŸ‘ 127    πŸ” 21    πŸ’¬ 3    πŸ“Œ 2
Indiana Jones and the Last Crusade: Learning from Stoppard
By  Mike Fitzgerald, June  13, 2016

Comparing two drafts of a script can be hugely instructive, revealing point-by-point how a writer went about improving the story. When I stumbled upon an earlier draft of Indiana Jones and the Last Crusade, I discovered a dazzling, glittering trove of lessons as nourishing as eternal life itself. Well, nearly so.

Last Crusade was written by Jeffrey Boam, from a story by George Lucas and Menno Meyjes. So say the opening credits. Boam’s final draft, dated March 1, 1988 (ten weeks before production) differs drastically from the published script which reflects the released version of the film. Differences come as no shock, but with Last Crusade they aren’t just a few deleted scenes and some line changes. Whole sections of the Boam draft were reimagined, major set pieces were added, and the pacing and tone were markedly transformed. Whoever made these changes possessed a profound grasp of story craft.

Screenshot from https://www.creativescreenwriting.com/indiana-jones-and-the-last-crusade-learning-from-stoppard/

Indiana Jones and the Last Crusade: Learning from Stoppard By Mike Fitzgerald, June 13, 2016 Comparing two drafts of a script can be hugely instructive, revealing point-by-point how a writer went about improving the story. When I stumbled upon an earlier draft of Indiana Jones and the Last Crusade, I discovered a dazzling, glittering trove of lessons as nourishing as eternal life itself. Well, nearly so. Last Crusade was written by Jeffrey Boam, from a story by George Lucas and Menno Meyjes. So say the opening credits. Boam’s final draft, dated March 1, 1988 (ten weeks before production) differs drastically from the published script which reflects the released version of the film. Differences come as no shock, but with Last Crusade they aren’t just a few deleted scenes and some line changes. Whole sections of the Boam draft were reimagined, major set pieces were added, and the pacing and tone were markedly transformed. Whoever made these changes possessed a profound grasp of story craft. Screenshot from https://www.creativescreenwriting.com/indiana-jones-and-the-last-crusade-learning-from-stoppard/

Nine years ago Mike Fitzgerald wrote up an extraordinarily fascinating breakdown of the differences between the Tom Stoppard shooting script and the original Jeffrey Boam draft of Indiana Jones and The Last Crusade.

It's well worth your time: www.creativescreenwriting.com/indiana-jone...

02.07.2025 18:25 β€” πŸ‘ 727    πŸ” 333    πŸ’¬ 12    πŸ“Œ 44

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