Jan Werner

📃Just published in JNM: our recent study showing the clinical value of FET PET to identify early response to Regorafenib in patients with #glioma.

🔗: jnm.snmjournals.org/content/earl...

Thanks to @galldiks.bsky.social, @ph-lohmann.bsky.social and co-authors.

#aminoacidPET #braintumor

🚨 Today at #SNO2025 don’t miss the ASNO-EANO-SNO young investigator debates at 2:45 PM.
@neuroonc.bsky.social @eanoassociation.bsky.social #ArtificialIntelligence #NeuroOncology @mjlimfat.bsky.social @spyridonbakas.bsky.social @ph-lohmann.bsky.social

Start of the Educational Day of #SNO2025 and WFNOS2025. Welcoming by @mjlimfat.bsky.social. Looking forward to an inspiring conference in Honolulu. @neuroonc.bsky.social @eanoassociation.bsky.social

Awarded as best clinical science poster at #EANO2025 and now published online: "Clinical potential of [18F]FET PET in patients with circumscribed astrocytic glioma" by @jmwerner.bsky.social and colleagues.
👉 link.springer.com/article/10.1...
#NuclearMedicine #Glioma #NeuroOncology #PETImaging

Outstanding oral presentation at #EANO2025 in Prague, now published in #NeuroOncology: the Multicenter Randomized Phase II Study of R-MPV-A #Chemoimmunotherapy With or Without Low-Dose Whole-Brain #Radiotherapy for Newly-Diagnosed Primary... by Antonio Omuro & colleagues.
👉 doi.org/10.1093/neuo...

Two studies led by former #EANO President Matthias Preusser demonstrate the activity of HER3-DXd in patients with brain metastases from breast and lung cancer.
Just published back-to-back in @thelancetoncol.bsky.social:
👉 breast cancer: bit.ly/4oEN1T2
👉 lung cancer: bit.ly/3LarqUf
#TUXEDO3

#EANO2025 Emeline Tabouret reporting on theranostic potentials in Neuro-Oncology and currently ongoing trials including #EORTC trial LUMEN-1.
Moreover several interesting targets and trials in meningioma, adult and pediatric gliomas.

Happy to provide an overview of modern PET imaging in Neuro-Oncology at the joint EANO-EANM session #EANO2025. Use the RANO/EANO recommendations in clinical practice and apply/evaluate PET RANO 1.0 and PET RANO BM 1.0
@eanoassociation.bsky.social
@galldiks.bsky.social
@nathaliealbert.bsky.social

Fully automated evaluation of FET PET in brain tumors presented at #EANO2025. Multicenter effort with validation of >1800 PET scans comparing automated workflow with manual evaluations. @ph-lohmann.bsky.social @fz-juelich.de @eanoassociation.bsky.social

@mjlimfat.bsky.social closes the educational day at #EANO2025 with remarks and guidance on Pregnancy and Fertility Preservation in patients with brain tumors. @eanoassociation.bsky.social

💡Only a few seats left for the EANO Tumor Board 2025, taking place on October 15 in Prague. Join us for interactive case-based discussions and expert insights. Registration is free for EANO members. Please register by October 3.
Learn more: www.eano.eu/eanomeetings...

Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial - Nature Medicine In a phase 1/2a umbrella trial in patients with glioblastoma matching targeted therapies according to tumor molecular profiling, temsirolimus plus radiotherapy improved PFS compared to standard of car...

🧠 The phase 1/2 N2M2 umbrella trial lead by former EANO president @wickwolfgang.bsky.social has just been published in Nature Medicine
🔗 www.nature.com/articles/s41...

#NeuroOncology #EANOessentials #BrainTumors #CancerResearch

🧠 Just published in Neuro-Oncology: A comprehensive consensus review by @neuroonc.bsky.social and EANO on current management and future directions in adult #Glioblastoma care. Explore key recommendations and research priorities.
🔗 academic.oup.com/neuro-oncolo...

#NeuroOncology

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

👉 An article discussing nerve-to-cancer transfer of mitochondria during cancer metastasis is now available in @nature.com 🔗 www.nature.com/articles/s41... #CancerResearch #BrainMetastases #NeuroOncology #EANOessentials #Nature #medsky

📣 New journal launch! Neuro-Oncology Pediatrics is live — an open-access journal advancing global research and care for children & young adults with brain tumors.
A joint EANO & @neuroonc.bsky.social initiative.
🔗 Read more: www.eano.eu/about/news/n...
#NeuroOncology @oxfordacademic.bsky.social

Brain editing now ‘closer to reality’: the gene-altering tools tackling deadly disorders Stunning results in mice herald gene-editing advances for neurological diseases.

Scientists are closing in on the ability to apply genome editing to a formidable new target: the human brain.

go.nature.com/3HCKJUy

YouTube video by Ludwig Boltzmann Gesellschaft Die KFG ATTRACT

🧠 What is #ATTRACT – and how could it improve #glioblastoma care? This video (🇩🇪 with 🇬🇧 subs) explains how we test 28 drugs on tumor cells & personalize therapy.

Made by @lbg.ac.at w/ Anna Berghoff (ATTRACT Head), @mj-mair.bsky.social (Deputy Head) & Matthias Preusser (Mentor) 🚀
youtu.be/NfxxMZ_xmF4

🧠 Just published in @thelancetoncol.bsky.social: Updated RANO and EANO recommendations on the clinical use of PET imaging in gliomas.
🔗 Read more: www.thelancet.com/journals/lan...
#NeuroOncology #Glioma #PETimaging #EANO #RANO #BrainTumor #LancetOncology

Point/counterpoint: Upfront BRAF inhibition for adult BRAF-mutant high-grade gliomas Gliomas classified as CNS WHO grade 3 and 4 (herein referred to as HGG) are aggressive, fast-growing tumors with a poor prognosis and limited therapeutic o

Happy to share our collaborative Point/Counterpoint article on upfront #BRAF inhibition for adult high-grade #gliomas - a summary of the first joint SNO/EANO Young Investigators debate at #SNO2024. @marjoleingeurts.bsky.social @mjlimfat.bsky.social doi.org/10.1093/neuo...

Brain health for all ages: a global call to action The World Federation of Neurology represents 125 member societies globally and aims to foster brain health and quality neurology worldwide. The term brain health has become an acknowledged term of cru...

"43% of the global burden of disease is neurological, a concerningly high number."

On #WorldBrainDay, a new letter—Brain health for all ages: a global call to action ➡️ tinyurl.com/yjvtunj3

Stereotactic Radiosurgery in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases: A Multi-Institutional, Phase II, Prospective Clinical Trial PURPOSEStereotactic radiation (SRS/SRT) as opposed to whole-brain radiation (WBRT) represents the standard of care for patients with a limited number of brain metastases given the relatively favorable...

A recent publication in Journal of Clinical Oncology covers stereotactic radiosurgery in small cell lung cancer patients with 1–10 brain metastases, from a multi-institutional phase II prospective trial.
🔗 ascopubs.org/doi/10.1200/...
#NeuroOncology #Glioma #BrainMetastases #EANOessentials #medsky

RANO criteria for response assessment of brain metastases based on amino acid PET imaging Nature Medicine - The Response Assessment in Neuro-Oncology (RANO) group defines a standardized framework for amino acid PET imaging of brain metastases for use in clinical trials and eventually in...

🌍 Full text access to the PET RANO BM 1.0 criteria for response assessment of brain metastases based on amino acid PET imaging:
rdcu.be/ew8m0.

👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky

Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target Elp1 heterozygous LOF mutations in Sonic hedgehog medulloblastoma (MB) elevate transformation risk in granule neuron precursors through stalled differentiation, DNA replication stress, genomic instabi...

🧠 Recently published in Cancer Cell: Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target. Read the full article: www.cell.com/cancer-cell/... #EANOessentials #NeuroOncology #MalignantBrainTumor #medulloblastoma #medsky

Predicting therapeutic clinical trial enrollment for adult patients with low- and high-grade glioma using supervised machine learning Supervised machine learning models were designed and externally validated to predict glioma therapeutic clinical trial enrollment.

A new article addressing clinical trial enrollment of glioma patients using supervised machine learning is now available in Science Advances.
📖 Read the full article: www.science.org/doi/10.1126/...
#EANOessentials #NeuroOncology #Glioma #MachineLearning #medsky

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

🧠 Recently published in Nature Cancer: Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions Learn more: www.nature.com/articles/s43...

#EANOessentials #NeuroOncology #MalignantBrainTumor #PediatricBrainCancer #medsky

Clinical, molecular and radiological predictors of prognosis in newly diagnosed astrocytoma, IDH-mutant, WHO grade 4 AbstractBackground. Astrocytoma, isocitrate dehydrogenase-mutant, WHO grade 4 (Astro4), is a new tumor type in the 2021 WHO classification of central nervo

Recently published in Neuro-Oncology: Clinical, molecular and radiological predictors of prognosis in newly diagnosed astrocytoma, IDH-mutant, WHO grade 4. 🔗 doi.org/10.1093/neuo...

#EANOessentials #NeuroOncology #glioma #medsky

Availability and use of PET in patients with brain tumours – a European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) survey - European Journal of Nuclear Medicine... Purpose Positron emission tomography (PET) is increasingly used in neuro-oncology. However, little is known about its application across European institutions and reasons for variable implementation. ...

🧠 A recent EORTC - European Organisation for Research and Treatment of Cancer study highlights the availability and use of amino acid PET in patients with brain tumors. 🔗 Read the full story: link.springer.com/article/10.1...
#EANOessentials #NeuroOncology #MalignantBrainTumor #PETimaging #medsky

🧠 New EORTC survey shows PET imaging is widely available and used across European brain tumour centres.

With data from 103 centres in 20 countries, the findings support PET-based endpoints in future trials.

🔗 Find out more: www.eortc.org/blog/2025/07...

#EORTCbrain #PETImaging