Jan Werner

💡Only a few seats left for the EANO Tumor Board 2025, taking place on October 15 in Prague. Join us for interactive case-based discussions and expert insights. Registration is free for EANO members. Please register by October 3.
Learn more: www.eano.eu/eanomeetings...

Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial - Nature Medicine In a phase 1/2a umbrella trial in patients with glioblastoma matching targeted therapies according to tumor molecular profiling, temsirolimus plus radiotherapy improved PFS compared to standard of car...

🧠 The phase 1/2 N2M2 umbrella trial lead by former EANO president @wickwolfgang.bsky.social has just been published in Nature Medicine
🔗 www.nature.com/articles/s41...

#NeuroOncology #EANOessentials #BrainTumors #CancerResearch

🧠 Just published in Neuro-Oncology: A comprehensive consensus review by @neuroonc.bsky.social and EANO on current management and future directions in adult #Glioblastoma care. Explore key recommendations and research priorities.
🔗 academic.oup.com/neuro-oncolo...

#NeuroOncology

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

👉 An article discussing nerve-to-cancer transfer of mitochondria during cancer metastasis is now available in @nature.com 🔗 www.nature.com/articles/s41... #CancerResearch #BrainMetastases #NeuroOncology #EANOessentials #Nature #medsky

📣 New journal launch! Neuro-Oncology Pediatrics is live — an open-access journal advancing global research and care for children & young adults with brain tumors.
A joint EANO & @neuroonc.bsky.social initiative.
🔗 Read more: www.eano.eu/about/news/n...
#NeuroOncology @oxfordacademic.bsky.social

Brain editing now ‘closer to reality’: the gene-altering tools tackling deadly disorders Stunning results in mice herald gene-editing advances for neurological diseases.

Scientists are closing in on the ability to apply genome editing to a formidable new target: the human brain.

go.nature.com/3HCKJUy

YouTube video by Ludwig Boltzmann Gesellschaft Die KFG ATTRACT

🧠 What is #ATTRACT – and how could it improve #glioblastoma care? This video (🇩🇪 with 🇬🇧 subs) explains how we test 28 drugs on tumor cells & personalize therapy.

Made by @lbg.ac.at w/ Anna Berghoff (ATTRACT Head), @mj-mair.bsky.social (Deputy Head) & Matthias Preusser (Mentor) 🚀
youtu.be/NfxxMZ_xmF4

🧠 Just published in @thelancetoncol.bsky.social: Updated RANO and EANO recommendations on the clinical use of PET imaging in gliomas.
🔗 Read more: www.thelancet.com/journals/lan...
#NeuroOncology #Glioma #PETimaging #EANO #RANO #BrainTumor #LancetOncology

Point/counterpoint: Upfront BRAF inhibition for adult BRAF-mutant high-grade gliomas Gliomas classified as CNS WHO grade 3 and 4 (herein referred to as HGG) are aggressive, fast-growing tumors with a poor prognosis and limited therapeutic o

Happy to share our collaborative Point/Counterpoint article on upfront #BRAF inhibition for adult high-grade #gliomas - a summary of the first joint SNO/EANO Young Investigators debate at #SNO2024. @marjoleingeurts.bsky.social @mjlimfat.bsky.social doi.org/10.1093/neuo...

Brain health for all ages: a global call to action The World Federation of Neurology represents 125 member societies globally and aims to foster brain health and quality neurology worldwide. The term brain health has become an acknowledged term of cru...

"43% of the global burden of disease is neurological, a concerningly high number."

On #WorldBrainDay, a new letter—Brain health for all ages: a global call to action ➡️ tinyurl.com/yjvtunj3

Stereotactic Radiosurgery in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases: A Multi-Institutional, Phase II, Prospective Clinical Trial PURPOSEStereotactic radiation (SRS/SRT) as opposed to whole-brain radiation (WBRT) represents the standard of care for patients with a limited number of brain metastases given the relatively favorable...

A recent publication in Journal of Clinical Oncology covers stereotactic radiosurgery in small cell lung cancer patients with 1–10 brain metastases, from a multi-institutional phase II prospective trial.
🔗 ascopubs.org/doi/10.1200/...
#NeuroOncology #Glioma #BrainMetastases #EANOessentials #medsky

RANO criteria for response assessment of brain metastases based on amino acid PET imaging Nature Medicine - The Response Assessment in Neuro-Oncology (RANO) group defines a standardized framework for amino acid PET imaging of brain metastases for use in clinical trials and eventually in...

🌍 Full text access to the PET RANO BM 1.0 criteria for response assessment of brain metastases based on amino acid PET imaging:
rdcu.be/ew8m0.

👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky

Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target Elp1 heterozygous LOF mutations in Sonic hedgehog medulloblastoma (MB) elevate transformation risk in granule neuron precursors through stalled differentiation, DNA replication stress, genomic instabi...

🧠 Recently published in Cancer Cell: Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target. Read the full article: www.cell.com/cancer-cell/... #EANOessentials #NeuroOncology #MalignantBrainTumor #medulloblastoma #medsky

Predicting therapeutic clinical trial enrollment for adult patients with low- and high-grade glioma using supervised machine learning Supervised machine learning models were designed and externally validated to predict glioma therapeutic clinical trial enrollment.

A new article addressing clinical trial enrollment of glioma patients using supervised machine learning is now available in Science Advances.
📖 Read the full article: www.science.org/doi/10.1126/...
#EANOessentials #NeuroOncology #Glioma #MachineLearning #medsky

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

🧠 Recently published in Nature Cancer: Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions Learn more: www.nature.com/articles/s43...

#EANOessentials #NeuroOncology #MalignantBrainTumor #PediatricBrainCancer #medsky

Clinical, molecular and radiological predictors of prognosis in newly diagnosed astrocytoma, IDH-mutant, WHO grade 4 AbstractBackground. Astrocytoma, isocitrate dehydrogenase-mutant, WHO grade 4 (Astro4), is a new tumor type in the 2021 WHO classification of central nervo

Recently published in Neuro-Oncology: Clinical, molecular and radiological predictors of prognosis in newly diagnosed astrocytoma, IDH-mutant, WHO grade 4. 🔗 doi.org/10.1093/neuo...

#EANOessentials #NeuroOncology #glioma #medsky

Availability and use of PET in patients with brain tumours – a European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) survey - European Journal of Nuclear Medicine... Purpose Positron emission tomography (PET) is increasingly used in neuro-oncology. However, little is known about its application across European institutions and reasons for variable implementation. ...

🧠 A recent EORTC - European Organisation for Research and Treatment of Cancer study highlights the availability and use of amino acid PET in patients with brain tumors. 🔗 Read the full story: link.springer.com/article/10.1...
#EANOessentials #NeuroOncology #MalignantBrainTumor #PETimaging #medsky

🧠 New EORTC survey shows PET imaging is widely available and used across European brain tumour centres.

With data from 103 centres in 20 countries, the findings support PET-based endpoints in future trials.

🔗 Find out more: www.eortc.org/blog/2025/07...

#EORTCbrain #PETImaging

ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis AbstractBackground. Advances in our technological capacity to interrogate CNS tumor biology have led to the ever increasing use of genomic sequencing in di

🧬 A new article on ultra-rapid tumor diagnosis is now available in Neuro-Oncology: "ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next ..." 🔗 Full access: doi.org/10.1093/neuo...
#EANOessentials #NeuroOncology #MalignantBrainTumor #methylomics #medsky

Live from #ASCO25 in Chicago: presentation of latest results on HER3-DXd efficacy and safety in patients with leptomeningeal metastatic disease of solid tumors - with simultaneous publication in Nature Medicine.
Learn more: doi.org/10.1038/s415... #NeuroOncology

For cancer biologist Johanna Joyce, teaching is essential to being a well-rounded scientist Advice on finding a supportive academic environment, building inclusivity in science, tackling scientific problems with an open mind, and more from Dr. Joyce.

#50ScientistsThatInspire 🧪

A collection created by @cellpress.bsky.social for #Cell50 🎉

Including inspiring #scientists and committed #advocates in their communities 🙌

In this 🧵 I'll share some of the interviews - including this Q&A we did 👇

Its an honor to be part of this incredible list 🙏 🙏

Charting the Single-Cell and Spatial Landscape of IDH-Wildtype Glioblastoma with GBmap AbstractBackground. Glioblastoma (GB), particularly IDH-wildtype, is the most aggressive brain malignancy with a dismal prognosis. Despite advances in mole

Recently published in Neuro-Oncology: Charting the Single-Cell and Spatial Landscape of IDH-Wildtype Glioblastoma with GBmap. Read full article 👉 doi.org/10.1093/neuo... #EANOessentials #Neuro-Oncology #glioma #glioblastoma

💪Neuro-Oncology Pediatrics – a new open access journal by EANO & @neuroonc.bsky.social for the global #pediatric & AYA #NeuroOncology community. Now open for submissions!
🔗 academic.oup.com/neuro-onc-peds
Editor-in-Chief: S. Mueller
Executive Editors: M. A. Roldán (EANO), @bandolab.bsky.social (SNO)

🧠 Join the next #EANOYoungsters Journal Club on June 5, 16:30–17:30 CEST!
Discussing: "Rapid molecular profiling of CNS tumors" www.nature.com/articles/s41... (Patel et al., Nat Med 2025)
📍Free & open to all EANO members
🔗 www.eano.eu
#NeuroOncology #BrainTumors #JournalClub

PhD Student (f/m/x) in experimental oncology We are looking to support our rapidly growing team as soon as possible:

Interested in telomere maintenance?
📢 Open PhD position in experimental oncology!

Please distribute.

jobs-uk-koeln.onlyfy.jobs/job/sypg9i9n...

🤩 The stage is set for day 2 of #NMN2025! Getting ready for another day full of cutting edge science on molecular imaging and theranostics of gliomas, brain metastases and meningioms. 🧠
www.nmn-society.org/program/

Excellent debates and talks in Vienna during the second day of #NMN2025 meeting. Already looking forward to next year!

@nmnsymposium.bsky.social
@galldiks.bsky.social
@nathaliealbert.bsky.social
@marjoleingeurts.bsky.social

Live from @nmnsymposium.bsky.social in Vienna: introduction of first RANO criteria for response assessment of brain metastases based on amino acid PET - with simultaneous publication in Nature Medicine. Learn more: www.nature.com/articles/s41...
#braincancer #PETimaging