The Hassan Brain Development Team

I owe this “career award” to everyone who has been part of @hassanbraindevlab.bsky.social over the years ❤️

Post-translational Tuning of Human Cortical Progenitor Neuronal Output - preLights On post-translational modifications and their contribution to help shape human cortical development

On post-translational modifications & their contribution to help shape human cortical development 🧠

Jawdat Sandakly covers a recent #preprint from Julien Pigeon and colleagues @hassanbraindevlab.bsky.social. #DevBio #Neuroscience

Read the #preLight ⬇️👀
prelights.biologists.com/highlights/p...

Please check out and RT this new position for an exciting collaborative project with @boninlab.bsky.social and @franckp.bsky.social on the links between human-specific mechanisms and neurodevelopmental disorders in cortical circuits.

Today we had the pleasure of hosting Dr. Bassem Hassan @hassanbraindevlab.bsky.social from @institutducerveau.bsky.social at our #SeminarsIN with his talk: “Temporal control of neurogenesis”
A fantastic lecture, thank you! 👏👏
@csic.es @dicv.csic.es @umh.es @borrell-lab.bsky.social

We have the pleasure of welcoming Dr Bassem Hassan @hassanbraindevlab.bsky.social from @institutducerveau.bsky.social tomorrow at #SeminarsIN 🙌
He is a world leader in the study of genetic regulation of brain development.
Don’t miss it!
@borrell-lab.bsky.social @csic.es @dicv.csic.es @umh.es

A wonderful collaboration with @alexbaffet.bsky.social @boyanbonev.bsky.social and @neurogenesis-i3s.bsky.social labs

Post-translational Tuning of Human Cortical Progenitor Neuronal Output The striking expansion of the human neocortex is driven by the ability of radial glial cells (RGCs) to prolong neurogenesis without exhausting their progenitor pool, thereby producing more neurons, pa...

www.biorxiv.org/content/10.1...
Our latest: Julien Pigeon and colleagues discover a mechanism linking post-translational modification of transcription factors to remodeling the chromatin landscape to regulate human cortical neurogenesis

👇🏽

Heterozygous pathogenic variants in the splicing factor SF1 lead to a large spectrum of neurodevelopmental disorders | Bassem Hassan Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder.

Latest from the lab: the immensely talented Johnny Bou Rouphael and Laila El Khattabi in the team report the discovery and functional analysis defective splicing in a human developmental disorder. www.linkedin.com/posts/bassem...

الحلقة الأولى من بودكاست "مقابلات مع علماء عرب حول العالم" متاحه للإستماع الآن 🎙️ 🧠 🔬 .. ضيفي للحلقة الأولى هو الدكتور باسم حسن (Bassem Hassan)، قائد فريق في معهد باريس للدماغ في فرنسا في ... الحلقة الأولى من بودكاست "مقابلات مع علماء عرب حول العالم" متاحه للإستماع الآن 🎙️ 🧠 🔬 .. ضيفي للحلقة الأولى هو الدكتور باسم حسن (Bassem Hassan)، قائد فريق في معهد باريس للدماغ في فرنسا في تخصص علم ا...

For those who understand Arabic 😊
A podcast about @bassemh.bsky.social work and career. Thank you Haifa Alhadyian, PhD for this amazing initiative.

www.linkedin.com/posts/activi...

Excited to share our latest paper in Nature Communications! We uncovered a dev-time transcriptional program (via Mirana → Pink1) that shapes mitochondria & circuit wiring.
Disrupt it early, and neurons miswire — even if the gene recovers later!

Registration is now open for 2026 GRC on Neural Development
@neuraldevgrc.bsky.social
Register early because places go fast!

Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity - Nature Communications This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal re...

Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social
labs
www.nature.com/articles/s41...

👋🏻 Bluesky!

image of web page for Neural Development GRC - go to https://www.grc.org/neural-development-conference/2026/

Bassem Hassan @bassemh.bsky.social, Corey Harwell & yours truly are co-chairs for 2026 Neural Development #GRC August 2-7, 2026 in Newport, RI 🇺🇸 - if you are interested in updates on the conference & to hear about our 🤩 line-up of speakers...follow @neuraldevgrc.bsky.social!
🧠🪰🐭🐙🐸🦎🧒🏻🧫🧪🧠

Congrats to the fantastic @maheandria.bsky.social on this well deserved recognition from French Academy of Science

This journey began in Berlin with @bassemh.bsky.social and Robin Hiesinger, and continued at @institutducerveau.bsky.social in @hassanbraindevlab.bsky.social , with the generous support of @frm-officiel.bsky.social . Grateful to the von Kleist & Stoeckli Labs and all co-authors!

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster - Nature Neuroscience The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in stereotyped neuronal circu...

A temporal sequence of genetically encoded stochastic mechanisms explains variation in stereotyped neuronal circuits in Drosophila 🧪🧠

@bassemh.bsky.social @maheandria.bsky.social @hassanbraindevlab.bsky.social @institutducerveau.bsky.social

www.nature.com/articles/s41...

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...

New from the lab: @maheandria.bsky.social and colleagues in collaboration with the Hiesinger, Stoeckli and von Kleist labs dissect the sequential emergence of axonal targeting during development in today's issue of Nature Neuroscience:
rdcu.be/ek010

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...

Hot off the press:
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010

👇🏽

Nencki Open Lab Decoding the brain: from methods to meaning Paris Brain Institute, June 2-4th 2025 Applying machine learning and other models to decode behavioral parameters from neural activity is now a standard …

Anna CHRZANOWSKA, PhD, postdoc in The Hassan Brain Development Team
@hassanbraindevlab.bsky.social
is organizing a trainee-led symposium @institutducerveau.bsky.social June 2-4

Spread the word!

nenckiopenlab.org/decoding/

Can't miss opportunity for anyone interested in developmental timing!! See you in Paris⏳️

Developmental timing across species: From mechanisms to evolutionary insights Like choreography, development consists of a highly ordered suite of steps and transitions. Modifying developmental tempo can affect final size and composition of tissues, as well as their plasticity…

Join us in Paris 6-9 May 2025 for the #EvoDevoTempo conference (2nd edition) with a fantastic line up of speakers confirmed!!

Organized by @mdiazcuadros.bsky.social
@vanderhaeghenp2.bsky.social
@bassemh.bsky.social and me.

Please RT to spread the word

meetings.embo.org/event/25-dev...

enews.embo.org?EventID=w25-...

Second edition of the EMBO workshop on Developmental Timing across species.
Second edition organized by
@trayon.bsky.social @bassemh.bsky.social @vanderhaeghenp2.bsky.social and Margerete Diaz-Cuadros

Cool speakers & fun networking activities.
More details coming soon.Save the date:
May 6-9 2025!

This is the Blue Sky account of the Hassan Brain Development lab. Let's connect!