Orr laboratory

Emerging Voices in GPCR Biology

A new special issue entitled “Emerging Voices in GPCR Biology” is now available in Molecular Pharmacology, highlighting innovative research led by early-career investigators (ECIs) across key areas of G protein-coupled receptor (GPCR) science.

www.sciencedirect.com/science/arti...

I started my own lab about 6 months ago at Ohio State where we’re continuing to look at ways to manipulate astrocyte biology to improve brain repair. We’re also generating new viral tools along the way, for use in research and hopefully in gene therapies for patients down the line.

Fluorescently labeled astrocytes at varying distances from cortical or white matter stroke infarct border

Huge congrats @amygleichman.bsky.social on this phenomenal study, demonstrating regional differences in astrocyte responses to stroke and a key role for astrocytes in post-stroke angiogenesis and repair!

(see also - gorgeous astrocytes for fluorescence Friday)

www.sciencedirect.com/science/arti...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

First approved drug for mitochondrial disease could pave way for more treatments Researchers are testing multiple treatments for the rare genetic conditions

Mitochondrial diseases have seemed intractable, but last month the Food and Drug Administration OK’d the first treatment targeting a mitochondrial flaw. https://scim.ag/4q3Ymxz

Jane Goodall obituary: pioneer primatologist who inspired generations of scientists She was a tireless advocate for conservation, the welfare of captive chimpanzees and the protection of habitats.

Obituary: Jane Goodall (1934-2025) Pioneer primatologist who inspired generations of scientists

go.nature.com/48aWjRU

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models - Nature Neuroscience Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.

Intriguing new insights on axonal TDP-43 in ALS from @labperlson.bsky.social and colleagues

www.nature.com/articles/s41...

Postdoc Researcher: Frontotemporal Lobar Degeneration Postdoctoral Researcher at VIB-CMN Antwerp with Dr Rosa Rademakers. Focus on genetics of FTLD using advanced sequencing, bioinformatics, & integrative analysis.

Postdoctoral Researcher Vacancy at VIB-CMN Antwerp with Dr Rosa Rademakers. Focus on genetics of FTLD using advanced sequencing, bioinformatics, and integrative analysis. Closing date: 24th November

www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Link to HHMI preprint mandate hhmicdn.blob.core.windows.net/policies/Imm...

Careers at LIBD | Medical Research Jobs | Lieber Institute View our career opportunities with Lieber Institute for Brain Development including investigators, medical research jobs, scientists, & lab techs

We have several positions open at various levels (Research Assistant, Research Associate, Postdoctoral Fellow) across our highly interactive teams in the Division of Translational Neuroscience 🧠🔬🧪 @lieberinstitute.bsky.social

www.libd.org/careers/

Links to individual positions in the thread below.

An interoceptive model of energy allostasis linking metabolic and mental health Interactions between metabolic interoception and regulation may drive comorbidity between mental and metabolic ill-health.

Mental and metabolic health are closely linked - but what drives this connection? In our new theory paper, we (w/ @camillanord.bsky.social & @hugofleming.bsky.social g.bsky.social) propose dysregulation of interoceptive energy allostasis as a key mechanism.
www.science.org/doi/10.1126/... 🧵 1/n

I have gotten a bit behind at sharing the lab’s latest work - this paper is now published - check it out! www.cell.com/cell-reports... Long story short: insulin is the major determinant of female fat storage, with a relatively minor effect on males.

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”

This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.

🔗 www.cell.com/cell/fulltex...

Faust et al., Cell 2025

Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research The budget proposal outlines the additional funding needed in FY27 to advance NIH-supported research toward achieving the goals outlined by the National Plan to Address Alzheimer’s Disease.

🤩Additional funding for AD & ADRD
Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research
www.nia.nih.gov/about/budget...

Sensory neurons shape local macrophage identity via TGF-β signaling @cp-immunity.bsky.social
www.cell.com/immunity/ful...

A potential trauma-related astrogliopathy?

Subpial tau astrogliopathy is frequently seen alongside CTE lesions and we also see it in our repeated head impact cases that don't have CTE. It's exciting to see new data exploring this.

Astrocyte networks span large swaths of brain The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows.

By @callimcflurry.bsky.social

#neuroskyence

www.thetransmitter.org/astrocytes/a...

Submissions for late-breaking abstracts are now open!  

Share your most recent and exciting research with a global audience at #SfN25. 

Submit your late-breaking abstract by Wednesday, September 10. 

🔗 vist.ly/45gzc

#neurosky #neuroskyence #academicchatter

APOE genotype influences on the brain metabolome of aging mice – role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype - Molecular Neurodegeneration Alzheimer’s disease (AD) risk and progression are significantly influenced by APOE genotype with APOE4 increasing and APOE2 decreasing susceptibility compared to APOE3. While the effect of those genot...

#APOE genotype influences on the brain #metabolome of aging mice – role for #mitochondrial energetics in mechanisms of #resilience in APOE2 genotype

Kamil Borkowski, Nuanyi Liang, Na Zhao..Rima Kaddurah-Daouk @dukemedschool.bsky.social @metabolomics-wcmc.bsky.social @mayoclinic.org

bit.ly/4g0otRm

YouTube video by Dementia Researcher Being Innovation Minded

Our Salon webinar recording release brings Dr Ella Moonan-Howard from Alzheimer's Society and Professor Richard Unwin from The University of Manchester to explore what is means for Researchers to be 'Innovation Minded'

youtu.be/pLssuT6A8W0

Katz has been a game changer for me and my lab, so happy to see it reissued!

Ever wanted to do a CRISPR screen directly in the mammalian brain? While perturbing thousands of genes in parallel? All while targeting specific cell types? Check out our latest paper describing CrAAVe-seq, a powerful new functional genomics tool for massively parallel neuroscience research

A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by abnormal accumulation of the RNA-binding protein TDP-43. Using a mouse model that mildly overexpresses human ...

Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...

YouTube video by Cure Alzheimer's Fund Cure Alzheimer's Fund Webinar Featuring Dr. Karen Duff

The Tangled Tale of Tau – Will Targeting Amyloid be Enough?”
In this webinar, Dr. Duff examines a critical question in Alzheimer’s research, exploring the complex roles of tau & amyloid in disease progression. youtu.be/alpEsCeiXQs

Why strong mentorship was essential for my career success in science JoAnn Trejo has turned mentoring into an evidence-based science, driven by her own exposure to inspiring mentors.

Here you go..." Why strong mentorship was essential for my career success in science" JoAnn Trejo has turned mentoring into an evidence-based science, driven by her own exposure to inspiring mentors. www.nature.com/articles/d41...

Thrilled to share our new study showing microglia prune astrocyte processes in adult brain, to regulate synaptic transmission, hypothalamic neuron activity, and salt-induced hypertension in🐀. Huge team effort - congratulations to all🥂🍾🎉

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

My new university's logo is a PSI! How frickin cool is that!

Help me grow a new lab at in IU Bloomington! We're seeking brilliant young scientists interested in memory representations, neuromodulation & aging.

Coordinator: bit.ly/3Hu3UzT
Postdoc: bit.ly/4oBZF6j

Accepting GS apps in the Fall!