Christian Frezza

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://

www.sciencedirect.com/science/article/abs/pii/S1097276525008196

Congratulations @bensahralab.bsky.social !!

Good Sunday, all! Here is an exciting selection of papers in #cancermetabolism and #mitochondrialbiology: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"Inside us there is something that has no name, that something is what we are."-José Saramago

Passenger

open.spotify.com/track/7IoK6j...

Oldie but goldie.

Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.

Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.

Alzforum
www.alzforum.org/news/researc...

Preprint
www.biorxiv.org/content/10.1...

I am not an expert on mitophagy, but I believe that a convincing tool is the mitoKeima but as always a triangulation of approaches is needed www.mblbio.com/bio/g/produc...

@korolchuklab.bsky.social
@prudentlab.bsky.social
@mitodynamics.bsky.social

any suggestion?

Organellar pH as an emerging vulnerability to exploit in cancer Cancer cells undergo metabolic reprogramming to sustain their energy demands, and favor glycolysis despite the presence of functional mitochondria. Th…

www.sciencedirect.com/science/arti...

Organellar pH as an emerging vulnerability to exploit in cancer

Congrats to @cosimocommisso.bsky.social

John Gurdon obituary: Biologist who made cloning possible He showed that specialized cells retain the genes to form an organism.

new out in Nature www.nature.com/articles/d41...

I cannot agree more! I would even say that biology nowadays doesn't need more data, but rather a new, radical view of its principles that would be impossible without approapriate philosophy insights.

Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical...

Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation: Trends in Pharmacological Sciences www.cell.com/trends/pharm...

Are these the happiest PhD students in the world? Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?

We asked 3,785 PhD students across 107 countries about their experiences. Where do you think the happiest doctoral candidates were?

go.nature.com/3Wzz2lL

A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...

What if the DNA methylation enzyme DNMT1 isn’t just about DNA?
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...

Good Sunday, mitolovers! 🌟 Exciting news in the world of #cancermetabolism and #mitochondrialbiology! 🧬 Check out the papers from last week here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading📚

"Knowledge is an unending adventure at the edge of uncertainty."-Jacob Bronowski

A Platform for Mitochondrial Profiling in Enriched Kidney Segments Under Thermodynamic Control in Mice and Humans Mitochondrial function varies widely across kidney nephron segments, yet conventional approaches lack the resolution and control needed to assess cell-type-specific bioenergetics in situ. We present a...

An updated preprint now includes segmented bioenergetic assessment of human kidney samples from rejected transplants or non-tumor resection. This methodological breakthrough allows for a highly-adaptable, rapid, and non-genetic means to separate heterogeneous tissues to profile OXPHOS.

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Excited to share that we are hiring a research assistant for my lab at UTSW in Dallas (www.nils-burger-lab.com). Please share with your mentees.
utsw.taleo.net/careersectio...

We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!

The problem with career planning in science Having too rigid a plan could result in exciting opportunities passing you by, warns Ottoline Leyser.

This week on the Nature Careers Podcast: How having too rigid a plan could result in exciting opportunities passing you by.

go.nature.com/3WHgwYs

Aged mice exhibit widespread metabolic changes but preserved major fluxes Metabolic dysregulation is a hallmark of aging, but how metabolic pathway activity (flux) changes with age has yet to be broadly assessed. Here, Jankowski et al. measure metabolite concentrations and ...

Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...

TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors Herbrich et al. demonstrate that TET2-mutant clonal hematopoiesis improves response to immune checkpoint therapy in the context of solid tumors. Intratumoral TET2-mutant macrophages are immunogenic an...

TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors: Cancer Cell www.cell.com/cancer-cell/...

Aged mice exhibit widespread metabolic changes but preserved major fluxes Metabolic dysregulation is a hallmark of aging, but how metabolic pathway activity (flux) changes with age has yet to be broadly assessed. Here, Jankowski et al. measure metabolite concentrations and ...

Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics Single-cell metabolomics (SCM) can probe metabolic heterogeneity but is hindered by low sensitivity for small molecules, limited scalability, and the lack of standardized frameworks for data analysis....

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...

Spatial metabolic gradients in the liver and small intestine - Nature Mapping of spatial metabolic gradients in the mouse liver and intestine identifies fructose-induced focal derangements in liver metabolism.

www.nature.com/articles/s41...

Spatial metabolic gradients in the liver and small intestine

Mitochondrial and psychosocial stress-related regulation of FGF21 in humans - Nature Metabolism FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosoc...

www.nature.com/articles/s42...

Mitochondrial and psychosocial stress-related regulation of FGF21 in humans

MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death - Nature Cell Biology Nguyen, Collier et al. find a mitochondria–lysosome inflammatory pathway regulated by the SUMO E3 ligase MAPL, which promotes vesicular mtDNA transport to lysosomes and subsequent gasdermin-dependent ...

MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell death

www.nature.com/articles/s41...

congrats @mitodynamics.bsky.social & team!!

Mapping Structural Aging across Human Tissues reveals tissue-specific trajectories, coordinated deterioration and genetic determinants Tissue structure, the organization of cells, vasculature and extracellular matrix, determines organ function. Yet how tissue structure changes with aging remains largely unknown. Current aging researc...

www.biorxiv.org/content/10.1...

very cool work and a massive effort from Sanju Sinha lab

NAD+ precursor supplementation in human ageing: clinical evidence and challenges - Nature Metabolism This Review summarizes existing data, as well as crucial knowledge gaps, emerging from clinical trials involving NAD+ precursor supplementation in humans.

www.nature.com/articles/s42...

Thanks for the clarification. indeed, the obscure articulation of the main concepts of WIL may have made it easier to be intentionally misconstrued by different schools. Thanks again for this deep dive.

#Autophagy and #mTOR paper published last week, lots of cool stuff, enjoy!

biomed.news/bims-auttor/...

Creatine fuels cancer. In @asbmbjournals.bsky.social we show CKB drives CK activity in NSCLC, osteosarcoma & ovarian cancer, promoting metastasis & anoikis resistance. Led by postdoc Mouna Tlili, in collaboration with Peter Siegel + @mcgillgci.bsky.social. Preproof: www.jbc.org/article/S002...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitnes www.science.org/doi/10.1126/...