Jeff Maltas

79. American citizen.

Faculty Professor Associate - Full-Time | Vaughn Cooper We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

Interested in doing a PhD in #MatOnco next year? Our department at @moffittnews.bsky.social is a great place to do research and we offer fully-paid tuition and fees. Apply before the deadline 12/1 at Moffitt.org/CancerPhD

I found this to be just as evident with reading. I spent some time having AI summarize new papers. I found it did a decent job! Only a month later I had retained none of the information of those papers. I had spent no time milling with the ideas, figures, or experiments. Useless.

Evolutionary Games: Mathematical Theory and Biological Insights

I am really happy to share that there will be a @nitmb.bsky.social workshop next year on mathematical and biological features of evolutionary game theory.

It was really fun to co-organize this workshop with Olivia Chu, Alex McAvoy, and @jplotkin.bsky.social.

www.nitmb.org/evolutionary...

1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬

www.science.org/doi/full/10....

When the filter is removed (change to non-selective environment), a higher dimensionality of pleiotropic effects becomes apparent.

The study finds no evidence for this hypothesis, and instead supports the "pleiotropic shift" model.

My understanding is this is correct. In their pleiotropic expansion model, the mutations all have a broad inherent pleiotropy, but the selective environment acts as a filter, allowing only a low-dimensional subset to be relevant for fitness in that environment.

The idea would be a sphere is perfectly captured by the l=0 harmonic, while less spherical shapes will required increasingly higher order harmonics to accurately describe. Maybe more resolution/information than surface area vs volume, but less intuitive to interpret for readers.

This might be something that decomposing the shape into its spherical harmonics could do quite well.... It's kind of like how a Fourier transform breaks a complex signal down into sines and cosines, but it's breaking a 3D shape down into orthogonal shapes on a sphere.

Really cool! Congratulations!

Ba6, c4, Rf3, b3, Rf8

Black looks really good but after c4 gumming up the nice mate, I'd find a way to lose this :)

I'm incredibly honored by this opportunity to serve as President-Elect of @asm.org starting this summer. Looking forward to working with the Board, ASM leadership ,and staff to help advance the microbial sciences. I'm also glad to share my Vision statement, please join us!
asm.org/Press-Releas...

Thanks Willem!

Signal Messenger: Speak Freely Say "hello" to a different messaging experience. An unexpected focus on privacy, combined with all of the features you expect.

WhatsApp is owned by Meta, the company behind Facebook, Instagram and, most recently, firing all their content moderators for political expediency.

So this is a reminder to download Signal, a free messenger run by a nonprofit which is like WhatsApp but more secure and private: signal.org

Really great new work from the always interesting @csabapallab.bsky.social lab!

For what it's worth, chrome and firefox both have extensions to high google AI, which is typically what I have going on.

Google search AI results for "highest dn/ds evolution measured" showing improved results.

Google AI is horrible. You alter the search even a little bit and the answer is dramatically different. I wish duckduckgo was a slightly better search engine.

As a final note, I just want to drop a shout out to Anh (not on bsky) who helped make this possible after I graduated. She did some important experiments during the revision process and she's a truly spectacular scientist.

As a result, collateral profiles are highly dynamic/variable through evolutionary time and we need a stochastic control model to optimize treatment. To do with we adapted our 2019 Markov Decision Process model to include temporally varying state profiles!

We see that adaptation to antibiotics results in near uniform collateral resistance, further adaptation results in both collateral sensitivity and resistance. This is very similar to recent work from @grantkinsler.bsky.social @petrovadmitri.bsky.social in their yeast two-step paper (also in PLOS B)!

Very excited to have this paper officially out. This one is pretty special... Unfortunately, @kevinwoodum.bsky.social passed away when this paper was in its final stages. He was my biggest supporter, and I miss him deeply as a mentor and friend.

Joe Scally 4 times?

NSF makes you say who you got conflicts (coauthored) with. We (really just Jordan Matelsky) just built you a tool for that. Literally one click: bib.experiments.kordinglab.com/nsf-coa

Incredibly honored to have participated! Thank you @seanmcarroll.bsky.social .

You were great on this episode, Brandon! And got shout outs to seascapes and evolutionary game theory!

Have you found a good starter pack for general evolution and ecology? I’ve only found cancer evolution.