Jonathan Friedman

Finally, we find that presequence strength influences yeast metabolism in a model of COX4 deletion. When fused to a leaderless COX4, only presequences that promote “strong” import behavior restore respiratory growth to wild-type levels. 8/n

Mitochondrial presequences harbor variable strengths to maintain organellar function Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack ...

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵

www.biorxiv.org/content/10.1...

Congrats!

Congrats Sam!

Niemi lab and @washubbsb.bsky.social graduate student Youmian Yan gave a fantastic presentation on her work at the @asbmb.bsky.social meeting in Chicago! #ProudPI (photo credit to @kerikozul.bsky.social)

This is a very sad day. Shock, despair, disappointment, disbelief... These only scratch the surface in describing this decision and how I feel. I began my career in Parkinson's research in Richard's lab. What happens now to all the trainees still there?

Come to St. Louis this summer for the United Mitochondrial Disease Foundation MitoMed 2025 Conference! We have a fantastic line up with lots of opportunities for short talks. We're also running a Masterclass for Early Career Investigators. More info here: www.umdfconference.org

Reminder to join us tomorrow at 12pm ET!

Lipid Research Division Seminar Series March 26, 2025 | 12 p.m. Eastern

Join us March 26th at 12pm ET - @asbmb.bsky.social LRD seminar series.

We have two great mitochondria-focused lipid talks planned from @jasoncasler.bsky.social from @lllackner.bsky.social's lab and Kailash Venkatraman from @ibudin.bsky.social's lab.

Register here! www.asbmb.org/meetings-eve...

Awesome news! Congrats!

Compositionally unique mitochondria in filopodia support cellular migration Marlar-Pavey et al. determine that a subpopulation of compositionally unique mitochondria, METEORs, dynamically localize to filopodia. Loss of mitochondrial targeting to filopodia correlates with a re...

Some good news (and fresh science) to break things up! Our work identifying a subpopulation of compositionally unique mitochondria that localize to filopodia and promote cell migration is now @currentbiology.bsky.social! Led by fantastic @madeleinempavey.bsky.social!

www.cell.com/current-biol...

An excellent opportunity!

A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope - Nature Cell Biology Mannino et al. provide a quantitative and ultrastructural timeline of nucleophagy in yeast with lattice light sheet microscopy and correlative light and electron tomography. They identify a role for d...

It’s so nice to be able to celebrate something this week. Newest work from the group! How are nuclear contents delivered to the cytosolic autophagy machinery while maintaining nuclear integrity? Nuclear envelope gymnastics! Cool role for Dnm1/Drp1. www.nature.com/articles/s41...

Congrats on the beautiful discovery! Awesome to see how this story has progressed. And yes, nice to have some positive news this week!

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

A big congrats to Alia on a successful thesis defense! @themitotracker.bsky.social gave an excellent talk and did the lab proud! 🥳🎉🍾

Thanks Itay! Hope you had a great holiday

Thanks! Not a bad finale at all!

New: @themitotracker.bsky.social et al. from @labfriedman.bsky.social identify a mitochondrial inner membrane protein that marks and facilitates a subset of sites of mitochondrial fission in human cells. rupress.org/jcb/article/...

Looking for some holiday reading material? Our latest paper identifying a new player in mitochondrial fission is now out @jcellbiol.bsky.social! A wonderful early present to see this now online!

rupress.org/jcb/article/...

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

You gave a great talk! Thanks for helping to contribute to a wonderful session!

Our executive editor with Alia Edington @themitotracker.bsky.social from @labfriedman.bsky.social, winner of the 2024 Alan Hall Travel Award! 👉 Be sure to catch Alia's talk today at #CellBio2024! Read about his year's winners: https://buff.ly/4gtpqRk

Excited to announce that I was awarded the Alan Hall Travel Award from @jcellbiol.bsky.social to attend #CellBio2024 this weekend! If you're attending this year, please join me at my poster or my talk (details below) to learn about my story on novel mediators of mitochondrial dynamics!

Congrats!!

Congrats Alia! 🎉🎉 Well deserved!

So proud of Alia Edington @themitotracker.bsky.social for winning the JCB Alan Hall Travel award to attend ASCB! Thank you @jcellbiol.bsky.social for recognizing the hard work of our trainees!

Be sure to check out Alia's talk 5pm Mon. in the organelle subgroup or at poster B143 Sun. 11:15!

As you're planning out your ASCB schedule be sure to attend the organelle-focused special interest group hosted by @nieminm.bsky.social and myself Mon. 12/16 at 5pm

Come hear a fantastic lineup of speakers including @walterwchen.bsky.social @themitotracker.bsky.social @lianjiejerrywei.bsky.social

Happy to have my first post on this site be to share the news that our amazing student Alia will be presenting her work on mitochondrial fission at MitoChats Thursday (10am US central time)! Be sure to check it out!