Dutch Society for Mass Spectrometry

Don’t miss out, only a few days left to submit your travel grant application (deadline 1st Feb 2026)! 😱😄 Apply here: www.nvms.nl/index.php/co...

Tandem FAIMS and IMS Combined with MS/MS for Effectively Probing the Structural Diversity of Proteins pubs.acs.org/doi/10....

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#proteomics #prot-paper

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics Accurate and comprehensive peptide spectrum annotation is a crucial step to interpreting mass spectrometry-based proteomics data. While peak assignment in peptide fragmentation spectra is central to a...

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry pubs.acs.org/doi/10.1021/.... Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.

ProteoBench: the community-curated platform for comparing proteomics data analysis workflows Mass spectrometry (MS)-based proteomics is a well-established strategy for analyzing complex biological mixtures. Many MS instruments and data acquisition strategies are available, and the data they a...

We are happy to share that the preprint for Proteobench is available now on biorxiv!
Check it out here: www.biorxiv.org/content/10.6...
Congratulations and thanks to everyone involved for the great effort!

An exciting 2026 ahead for mass spectrometry in the Netherlands 🎉
Eight travel grants to support early-career researchers attending IMSC 2026 ✈️🔬
Details and applications (deadline 1 Feb 2026): lnkd.in/eHavM4BG
Wishing you all a successful 2026!
Your NVMS board

A BIG THANK YOU to everyone who joined us at the NVMS Fall Meeting 2025! 👏 Your energy and ideas made the meeting truly inspiring and a great fit for the House of Connections. ✨♥️ A recap will be online soon: www.nvms.nl Your NVMS board
#NVMS #MassSpectrometry #ScienceCommunity #DEI #Groningen

Great work 👍 thank you for joining!

On my way to the @denvms.bsky.social fall meeting to present our antibody sequencing work 😁

From Identification to Insight: Making Full Use of the Diagnostic Potential of MS/MS Proteotyping in Clinical Microbiology Using Efficient Bioinformatics pubs.acs.org/doi/10....

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#proteomics #prot-paper

Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...

For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏

arxiv.org/abs/2508.096...

NVMS Fall Meeting 2025 – Program Announced! - NVMS We are pleased to share the full program for the upcoming NVMS Fall Meeting, taking place on Wednesday, November 19, 2025, at the House of Connections in Groningen.

We are excited to share the final program for the NVMS Fall Meeting on November 19, 2025, at the House of Connections in Groningen. Download the program here: www.nvms.nl/index.php/nv...

See you all there! 😀🧪✨

#NVMS #MassSpec #RUG #Science

Hey #TeamMassSpec,

Many non-human proteomics studies still search against taxon-filtered FASTAs.

❌ Redundant sequences
❌ Inflated search space
✅ Reference proteomes cut redundancy, improve annotation, and make results comparable.

👉 Time to move beyond taxon filters. #proteomics #massspec #uniprot

Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry Heck and colleagues developed a mass photometry-based method for accurate and fast mass determination of plasmid DNA. Conventional mass photometry methods are not applicable for large DNA particles; h...

Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids www.cell.com/molecular-th.... Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink

Modanovo: A Unified Model for Post-Translational Modification-Aware de Novo Sequencing Using Experimental Spectra from In Vivo and Synthetic Peptides Post-translational modifications (PTMs) play a central role in cellular regulation and are implicated in numerous diseases. Database searching remains the standard for identifying modified peptides fr...

Excited to share Modanovo, our transformer-based method for de novo peptide sequencing, which supports a broad range of post-translational modifications (PTMs)!
www.biorxiv.org/content/10.1...
#proteomics #massspectrometry #PTM

Molecular Characterization of Natural Organic Matter Using Complementary Liquid Chromatography–Mass Spectrometry and Gas Chromatography–Mass Spectrometry Techniques Given the impact of natural organic matter (NOM) on water quality and treatment, understanding its properties is essential in water chemistry. However…

Molecular Characterization of Natural Organic Matter Using Complementary Liquid Chromatography–Mass Spectrometry and Gas Chromatography–Mass Spectrometry Techniques #JChromA www.sciencedirect.com/science/arti...

What does a language model know about proteins? www.nature.com/artic...

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#proteomics #prot-paper

Great news! 🎉 The abstract deadline is extended to Oct 7, 2025! Don’t miss your chance to share your work 🚀 #NVMS #MassSpec

Join us for the NVMS Fall Meeting 2025 with the Dutch Mass Spec community!!!🧪✨😀

📅 19 November 2025
📍 House of Connections, Groningen

🎤 Present your research! Submit an abstract for a poster or oral presentation: www.nvms.nl/index.php/re...

Your NVMS Board

#NVMS2025 #MassSpec

Slice-PASEF: Maximising Ion Utilisation in LC-MS Proteomics Quantitative mass spectrometry (MS)-based proteomics has become a streamlined technology with a wide range of usage. Many emerging applications, such as single-cell proteomics, spatial proteomics of t...

www.biorxiv.org/content/10.1...

🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social

Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

New paper online:

Ångström-resolution imaging of cell-surface glycans.

The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.

#Glycotime

www.nature.com/articles/s41...

Enhancing Tandem MS Sensitivity and Peptide Identification via Ion Preaccumulation in an Orbitrap Mass Spectrometer High-throughput mass spectrometry-based proteomics has gained increasing interest for both academic and industrial applications. As implementation of faster gradients has facilitated higher sample thr...

Boosting Orbitrap MS/MS speed to ∼70 Hz? 🚀

Read how we did it in our latest paper 👇

pubs.acs.org/doi/10.1021/...

A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data - Nature Methods Cascadia is a mass spectrometry-based de novo sequencing model that uses a transformer architecture to handle data-independent acquisition data and achieves substantially improved performance across a...

www.nature.com/articles/s41...

A transformer model for de novo sequencing of data-independent acquisition mass spectrometry data - Nature Methods Cascadia is a mass spectrometry-based de novo sequencing model that uses a transformer architecture to handle data-independent acquisition data and achieves substantially improved performance across a...

We’re excited to announce the publication of Cascadia, our new de novo sequencing model designed for DIA data. By extending the transformer architecture to fully capture the complexities of DIA data, we achieve state-of-the-art performance.

www.nature.com/articles/s41...

Are you looking forward to attending #EuPA2025 in beautiful Saint-Malo? Get ready for an enriching experience in extraordinary #proteomics!

🗓️ Mark your calendar for the SCIEX lunch symposium, taking place on Wednesday, June 18!

🔗 Full show agenda 👉 bit.ly/3HcA6Hw

#SkepticsWelcome #ZenoTOF8600

Free structural MS hands-on workshop @ BIOCEV (CZ)

📅 Sept 15–19, 2025

For PhDs, postdocs & undergrads (CZ/SK)

HDX-MS, native MS, cross-linking, high-res MS, data processing

Apply by July 31 → bit.ly/3HNyzIg

@spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social

🌞Wishing everyone in the mass spec community a fantastic summer break!

Whether you are kicking back with the NVMS summer newsletter 👉 www.nvms.nl/index.php/nv... or diving into fresh data, wishing you sunshine, fun, and great results! 😄

#MassSpec #NVMS

Increased EThcD efficiency on the hybrid Orbitrap Excedion Pro Mass Analyzer extends the depth in identification and sequence coverage of HLA class I immunopeptidomes Gaining a complete and unbiased understanding of the non-tryptic peptide repertoire presented by HLA-I complexes by LC-MS/MS is indispensable for therapy design for cancer, autoimmunity and infectious...

We explored the Excedion Pro Mass Analyzer with faster & more efficient EThcD capabilities, launched @asms.org, to more efficiently convert MS2 spectra to PSMs, as quality & unambiguous identification are more important parameters than peptide numbers. www.biorxiv.org/content/10.1...

Couldn’t find and forgot to tag @lperezpaneda.bsky.social on this, she did awesome work analyzing the data!

Engineering Life 2025: ORIGIN AND FUNCTION OF MECHANICAL FORCES IN BIOLOGY Engineering Life 2025, biological forces, force spectroscopy, measuring forces, developmental forces, molecular motors, forces in morphogenesis, cytoskeleton, DNA mechanics, bionanotechnology

📢Conference alert📢

Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology.

engineering-life-dresden.de