Assad SM

Great Chat. Big thanks to @nephromommy-akshu.bsky.social and @roxnonna23.bsky.social the crisp #NephJC summary 🙌. Thanks for waking me up Akshaya. Grateful! 🙏

But I don’t see it going beyond the small privileged group of HLA matched patients !

There are too many IFs and BUTs involved
#NephJC

The problem here is that - as attractive as being IS free sounds - it comes with a huge load right from patient selection, ensuring HLA compatibility, putting a huge burden on donors (making the MDR 101) and a very high risk IS withdrawal trial - with risk of rejection for the KTRs #NephJC

Let's remember operational tolerance isn't always induced. Some patients, especially HLA-matched can already come off IS without MDR-101. We need better biomarkers to find these "spontaneous tolerants." #NephJC

Fascinating finding: many patients lost chimerism but stayed IS-free. 🤔 This suggests chimerism is a transient 'switch' to turn on tolerance, not the long-term mechanism itself. We urgently need to identify that mechanism for safer weaning protocols. #NephJC

The conditioning regimen (rATG + TLI) is a big deal. For non-malignant disease, the risk of severe infections should definitely be considered in depth. Infection risks remain a huge obstacle for routine adoption. #NephJC

This is a once-a-year plea for support #NephJC

Wasn't invited for the twinning photo.
Guess I’ll stick to mixed chimerism in renal transplants for my twinning goals.

Chimerism and Immune Tolerance: Can We Says Goodbye to Immunosuppression? — NephJC This week, we will discuss the use of creating chimeras to induce immune tolerance and its potential to decrease or eliminate the need for immunosuppression in kidney transplant recipients.

Check out the insightful summary by Dr Akshaya Jayachandran @nephromommy-akshu.bsky.social and Dr Natalia Nombera @roxnonna23.bsky.social #NephJC

Hey, I'm S M Assad, young Nephrologist from CMC Vellore, India.
No COI.
While some centers in India have explored steroid-free regimens and local stem-cell work, the complexity and cost of bespoke cell therapies mean we rely on conventional, cost-effective IS as the standard of care. #NephJC

It was. The book is focuses on the history of TB, but it’s definitely not historical. In India, it’s our present. TB plagues all communities and classes, and it’s probably nothing to be proud of, that I seem to know and see most of these situations day-in and out !
#NephJC

#NephJC Summer Book Club Everything Is Tuberculosis poetry — NephJC Akshaya Jayachandran, NephJC intern was inspired by John Green’s Everything is Tuberculosis to write the following poem.

Beautiful and meaningful poem by
@nephromommy-akshu.bsky.social inspired by @johngreensbluesky.bsky.social's
Everything is Tuberculosis

www.nephjc.com/news/2025/8/...

a cartoon llama says " much appreciated " with its hands folded in prayer ALT: a cartoon llama says " much appreciated " with its hands folded in prayer

Amazing Chat! A job very well done Akshaya! Have seen your passion and dedication over the past few days! Keep going! #NephJC

Mind The Gap: When eGFR Creatinine and Cystatin C Disagree — NephJC This week, we will discuss the clinical significance of eGFRdiff, the difference in eGFRcys (cystatin C) and eGFRcr (creatinine).

On 7/22/25 at 9pm EST only on Bluesky!
#NephSky #MedSky join us for a lively discussion.
We're debating eGFRdiff (the gap that is sometimes present between the eGFR of cystatin C and creatinine). What does it mean, what causes it and what you should do about it. #NephJC
www.nephjc.com/news/egfrdiff

Insights from the CRIC Study: Visual Abstract — NephJC Based on data from the CRIC study, this analysis dives deep into whether this lab mismatch is just noise… or a clinical signal we’ve been missing. Check out the beautiful visual abstract made by our NephJC interns Sai Vani Yellampalli and Akshaya Jayachandran . Great team work!!!

Check out the VA from @drsaivani.bsky.social and @nephromommy-akshu.bsky.social on eGFRdiff in the CRIC cohort.
#Nephsky #NephJC
www.nephjc.com/news/cricdiff

Hi I’m Assad, practising nephrologist from India, Flozinator but not a finerator (yet) !
My first #NephJC chat !
No COI

Attended #KSN2025 in Seoul 🇰🇷! Presented two posters at the conference! 👩🏻‍⚕️
A scintillating experience soaking in all the science, savouries and Seoul skies !! 😃🎏🥋🍜@assadsm.bsky.social
#nephrology #KSN #seoul #nephroconference

Attended @ksnmeeting 2025 at Seoul and had the opportunity to present my poster at the conference! Thrilled by the city’s vibrant cultural and modern landscape!!
@nephromommy-akshu.bsky.social

#nephrology #KSN #seoul #nephroconference

NephJC interns

The class of 2025, #NephJC interns

www.nephjc.com/news/2025/6/...

Follow them all here: go.bsky.app/7qJxtg

And Team B: #NephJC
@glomerican.bsky.social
@bogdan-agavriloaei.bsky.social
@nephromommy-akshu.bsky.social
@DrSaiVani.bsky.social
@roxnonna23.bsky.social

Welcome next #NephJC generation! New NephJC authors & creators debuting in July 2025, check them out & give them a follow! 📸
Team A:
@sejalplakhani.bsky.social
@notjustdialysis.bsky.social
@msocomd.bsky.social
@shelliefravel.bsky.social
@salinesolut.bsky.social
@jeyakimarmeyyappan.bsky.social