Carine Meignin 🪰🦠🧬🌈

Three fantastic keynote lectures to kick off #EDRC2025 Lucia Prieto-Godiño @crick.ac.uk the @embo.org sponsored lecture, Romain Levayer @pasteur.fr and Marta Llimargas @ibmb-csic.bsky.social

Contrats to Dominique Ferrandon’s team @adrienfranchet.bsky.social

REFEREE 1: “I conclude with a simple, direct statement - this is the best paper I have read all year!”
#TransparentPeerReview

Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses
@juliusbrennecke.bsky.social et al

www.embopress.org/doi/full/10....

The world has gone mad. Thinking of Michael Ashburner today - his vision and dedication to the scientific community remain an inspiration, reminding us of how science should be: open, collaborative, and driven by curiosity.

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯

Any lab using @flybase.bsky.social please donate using the link in post below.

This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

Images from the linked preprint showing Wingless stainings in the Drosophila wing imaginal disc. Targeting vps15 with two indepependent RNAi lines (paper also shows the same with a third line) does not result in a phenotype. In contrast, targeting vps15 with two independent sgRNA constructs and Cas9 results in strong accumulation of Wingless protein in perturbed cells.

Why use #CRISPR in #Drosophila when RNAi works so well? Because for some genes well is not good enough.

Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.

www.biorxiv.org/content/10.1...

Looking forward to the Physics within the Cell workshop on 16th June. Join if you want to discuss molecular motors and intracellular transport with me. More info here: iop.eventsair.com/pwtc2025/

1/10 Today in @science.org in collaboration with
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

📣 #Drosophila news! 🪰

The AMP mutant lines from Hanson et al. (bit.ly/eLifeHanson) & the many isogenic immunity strains generated by @lmvteixeira.bsky.social & @brunolemaitre.bsky.social groups are now in @vdrc-flies.bsky.social!

Find the 40 DrosDel Immunity Panel strains in VDRC library DD-Im ⬇️

📣 Junior PI Opportunity
Join CNRS Strasbourg to lead cutting-edge research on host-pathogen interactions in insects 🪰
450k€ package | Drosophila, RNA, immunity
IBMC + Labex NetRNA network
📅 Apply by June 30, 2025
🔗 ibmc.cnrs.fr/en/laboratoi...
#RNA #Insects #Drosophila #NetRNA #Immunity #JobAlert

In vivo Dicer-2 interactome during viral infection reveals novel pro and antiviral factors in Drosophila melanogaster Invertebrates rely mainly on RNA interference (RNAi) as a key defense mechanism against viral infections. The central protein of this process is an enzyme called Dicer-2, which senses and processes vi...

Checkout our last paper about Dicer-2 interactome in vivo dx.plos.org/10.1371/jour... #RNAi #Dicer #Drosophila

An intercellular metabolic relay for brain sparingin Drosophila https://www.biorxiv.org/content/10.1101/2025.04.02.645514v1

University of Minnesota Genomics Center Model Organism Sequencing Service Flyer. $25 for a 30x Drosophila genome.

Hey fellow Drosophila researchers - if you haven't heard, the UMGC is offering ultra low-cost genome sequencing! See here to learn more: z.umn.edu/UMGC-MOSS #Dros25

Application for Master in Integrative Biological Sciences (iBioS) - Apply on MonMaster before March 24th. Details on the flyer. imcbio.unistra.fr/imcbio-train...

We are looking for a #postdoc to discover cell-autonomous innate immune antiviral factors in mammals, based on newly-identified defense of prokaryotes!
#EvoCure #comparativeImmunology #virology
Please share
@inserm.fr @ciri-lyon.bsky.social @cnrsbiologie.bsky.social
ciri.ens-lyon.fr/teams/lp2l/j...

We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open!
www2.rnasociety.org

This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation Ribosomes cooperate through transient collisions to ensure efficient translation.

www.cell.com/cell/fulltex...

@marvintanenbaum.bsky.social

Fantastic study by the Tanenbaum lab

ECR fellowship for 2 years abroad. Excellent funding & offers the chance to build your own research direction.

📣 I have a non-model #Drosophila system ripe for collaboration - it's got a balancer chromosome, so GAL4/UAS becomes feasible. #EvolBio questions with functional genetics! Happy to chat.

Structure-guided discovery of viral proteins that inhibit host immunity Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity

Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors

A 🧵 1/10

www.cell.com/cell/abstrac...

📢Job alert

We have two postdoctoral positions available, starting in Spring 2025. These positions are part of research funded by an ERC Advanced Grant, focused on exploring evolutionary immunology (Evo-Immuno). #Postdoc #InnateImmunity

Do not hesitate to contact us. ibmc.cnrs.fr/en/laboratoi...

Graphical abstract of the Organelle Profiling paper, showing the workflow: Endogenously tagged organelle library; Native IP proteomics; Data-driven graph clustering; resulting in a subcellular proteome map with more than 7,600 proteins localized across 19 subcellular compartments.

Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/

1/3 🧪

📢Job alert

Are you interested in Drosophila genetics, insects, innate immunity, evolution? We are offering an exciting Group Leader position within the NetRNA consortium (labex-netrna.cnrs.fr/presentation...)

See below for more information and do not hesitate to contact us.

Calling all Junior(-ish) Drosophila Investigators 📣📣📣

Join us in June for the JEDIs Resurection :
flies-jedi.github.io/projects/202...

✅presentations from participants,
✅panel on publishing (with fantastic guests)
✅plenty of time for socializing

Register asap to help us with the first headcount

A conserved bacterial genetic basis for commensal-host specificity Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...

Drosophila and Lactiplantibacillus plantarum in the spotlight (again), what a wonderful model (disclaimer I am biased ;-) ).

Congrats Will and team!

www.science.org/doi/10.1126/...

ICYMI: we wrote a book. It's a free PDF, but you can also get a physical copy just in time for the holidays. Probably. I dunno. We don't actually get money from it.

This was a labour of love by Hannah & Bruno. Also I helped. Stocking stuffer idea: USB loaded with The #Drosophila Immunity Handbook 🪰

Abstract Submission - 66th Annual Drosophila Research Conference Visit our website to learn more.

Abstract submissions for Fly meeting in San Diego 2025 close soon. If you or your trainees are planning to attend, please send in your abstracts to maximize chances of being selected for a platform presentation: genetics-gsa.org/drosophila-2...

An evolutionary perspective to innate antiviral immunity in animals Viruses pose a significant threat to cellular organisms. Innate antiviral immunity encompasses both RNA- and protein-based mechanisms designed to sens…

Glad to share our latest review on innate antiviral immunity in animals with Joao Marques & Jean-Luc Imler www.sciencedirect.com/science/arti...

Antiviral RNA interference targets viral transcripts but not genomes of RNA viruses in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2024.04.10.588985v1 RNA interference (RNAi) mediated by the small interfering RNA (siRNA) pathway is a major antiviral m

Antiviral RNA interference targets viral transcripts but not genomes of RNA viruses in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2024.04.10.588985v1

Congratulations to Jean-Luc IMLER for @ERC_Research
Advanced Grants! Let's have fun on exciting Evo-immuno's project . #ERCAdG #unistra, #CNRS, #IBMC @unistra.fr

⚠️ Junior chair position - BIOLOGY OF HOST-PATHOGEN INTERACTIONS BEYOND VERTEBRATES #M3i #labexNetRNA
labex-netrna.cnrs.fr/2024/02/23/j...