Oliver Thon

🎉We’re celebrating the #SCALE-it-Best-PhD-Awards-2025, honoring exceptional researchers! 🎓 This year, three remarkable dissertations were recognized, selected from a highly competitive and multidisciplinary pool of candidates. 🧵

05.06.2025 09:41 — 👍 16    🔁 5    💬 1    📌 3

🎉 We’re absolutely thrilled: SCALE has been selected as a DFG Excellence Cluster!
A huge thank you to our incredible team—this would not have been possible without your dedication and talent. 🙌 @dfg.de
#ClustersOfExcellence #SCALEcluster 🧵

23.05.2025 07:27 — 👍 50    🔁 19    💬 4    📌 3

Single-molecule visualization of ATP-induced dynamics of the subunit composition of an ECF transporter complex under turnover conditions Nature Communications - The association and dissociation dynamics of the ECF transporter complex for vitamin B12 are visualized by single-molecule FRET, highlighting the original transport...

Solène’s 4.5 years of postdoctoral work in our lab (she started just before the corona pandemic) has now been published. A heroic effort that revealed -at the single molecule level- that ATP drives the dissociation of an ECF transporter complex under turnover conditions. See rdcu.be/elTKc

13.05.2025 19:30 — 👍 30    🔁 11    💬 0    📌 0

A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB Nature Communications - KtrAB is a major potassium uptake system that has been linked to the pathogenesis of many infectious bacteria. Here the authors show that KtrB from Vibrio alginolyticus...

This took us a while and I am all the happier it is finally out! I thought that simply adding ATP to purified potassium channel KtrAB should be sufficient to stabilize its active state. I was so wrong...
Read the full story on how an IDR facilitates channel opening upon membrane interaction.

12.05.2025 20:51 — 👍 62    🔁 21    💬 3    📌 2

A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ channel KtrAB Nature Communications - KtrAB is a major potassium uptake system that has been linked to the pathogenesis of many infectious bacteria. Here the authors show that KtrB from Vibrio alginolyticus...

Finally, it's out in Nat Commun! Excellent collaboration with my colleagues and friends in Frankfurt, especially @ihaenelt.bsky.social and Janet Vonck.
This work demonstrates the role of the intrinsically disordered N-terminus of KtrAB in channel opening.

Full story here: rdcu.be/elDYO

12.05.2025 09:34 — 👍 24    🔁 6    💬 0    📌 0

Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel pubmed.ncbi.nlm.nih.gov/39971906/ #cryoEM

20.02.2025 10:28 — 👍 5    🔁 4    💬 0    📌 0

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

17.01.2025 18:43 — 👍 424    🔁 134    💬 7    📌 19

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Take a look at our paper from last week where we probed the Molecular Architecture of Synaptic Vesicles by cryo-ET and integrative structural analysis

We found that V-ATPases interact with synaptophysin and describe some other molecules of this exciting organelle
🧠🔬❄️

www.pnas.org/doi/10.1073/...

03.12.2024 09:53 — 👍 31    🔁 8    💬 1    📌 1

Thank you for compiling the list. Could you add me?

21.11.2024 09:55 — 👍 1    🔁 0    💬 1    📌 0

Could you add me? Thanks!

21.11.2024 09:52 — 👍 1    🔁 0    💬 0    📌 0