Alexey Soshnev

Aere perennius: how chromatin fidelity is maintained and lost in disease Abstract. Multicellular organisms arise from a single genome template in the zygote, necessitating the cells of the developing embryo to up- and downregula

Don't post often but this is a good occasion: we wrote a huge review about mechanisms that preserve chromatin fidelity, and how its progressive degradation occurs in disease. Inspired by #oncohistones but mostly *not* about that. Bonus, snuck Horace into the title!
academic.oup.com/narmolmed/ar...

13.08.2025 14:35 — 👍 1    🔁 0    💬 0    📌 0

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

21.05.2025 17:22 — 👍 40    🔁 15    💬 0    📌 0

Taken from Sam Landman on FB but not sure if he is the artist. Graphic saying AI is for losers, reject fascism think for yourself. I can make Art that’s ugly and bad all by myself thank you very much

21.05.2025 19:08 — 👍 15780    🔁 7741    💬 42    📌 65

Not that I wont be thrilled to grow a shaggy mouse...

04.03.2025 18:06 — 👍 3    🔁 0    💬 0    📌 0

The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...

03.11.2024 15:20 — 👍 76    🔁 38    💬 5    📌 0