PARCC

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected Nature - In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake

go.nature.com/3X5lbUg

[Préannonce] Fin novembre, l’ANR participera au nouvel appel à projets transnational du partenariat européen pour la médecine personnalisée, EP PerMed "Médecine Personnalisée pour les maladies #cardiovasculaires, #métaboliques et #rénales" (#CARMEN2026)
➡ anr.fr/fr/detail/ca...

A full life cycle biological clock based on routine clinical data and its impact in health and diseases - Nature Medicine The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

A Loupy @PARCC and colleagues of the international consortium of digital twins in healthcare and medicine reveal distinct biological clock patterns across different life stages.
www.nature.com/articles/s41...

Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome Key PointsNK-cell phenotyping reveals impaired cytotoxicity, chronic activation, and exhaustion in VEXAS syndrome.Decreased circulating NK cells were indep

P Breillat and B Terrier from PL Tharaux team @PARCC showed that NK-cell dysfunction in VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome contributes to increased susceptibility to severe infections.
doi.org/10.1182/bloo...

EndoCompass project: research roadmap for adrenal and cardiovascular endocrinology AbstractBackground. Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in huma

Pr MC Zennaro @PARCC and colleagues from the European EndoCompass project initiative established a research roadmap for adrenal and cardiovascular endocrinology.
doi.org/10.1093/ejen...

This gene causes obesity — and shields against heart disease People with certain forms of the MC4R gene have lower cholesterol levels than do other individuals with a high body-mass index.

A gene that causes obesity is paradoxically linked to a reduced risk of having heart disease and high cholesterol, according to an analysis of thousands of people with obesity.

go.nature.com/4o2YDzC

Myocardial disarray drives metabolic inefficiency in human cardiomyocytes - Communications Biology Modelling cardiomyocyte geometry reveals that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism.

In this Communications Biology article, authors modeled cardiomyocyte geometry revealing that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient cardiac metabolism🫀
@parcc-inserm.bsky.social
doi.org/10.1038/s420...

Myocardial disarray drives metabolic inefficiency in human cardiomyocytes Communications Biology - Modelling cardiomyocyte geometry reveals that mitochondrial–sarcoplasmic architecture enhances respiration by facilitating ion and lipid transfer for efficient...

C Jouve and colleagues from Team Hulot @PARCC demonstrate that mitochondrial-sarcoplasmic architecture and geometry are critical spatial features that ensure bioenergetic efficiency of cardiomyocytes rdcu.be/eKD1n

The world’s first plastics treaty is in crisis: can it be salvaged? Hopes of securing a United Nations treaty on plastic pollution are fading after the final round of negotiations ended without an agreement.

Hopes of securing a United Nations treaty on plastic pollution are fading after the final round of negotiations ended without an agreement.

go.nature.com/3J74xjN

The global cardiovascular–liver–metabolic syndemic: epidemiology, trends and challenges Nature Reviews Cardiology, Published online: 06 October 2025; doi:10.1038/s41569-025-01220-4In this Review, Nicholas Chew and colleagues use epidemiological data on the cardiovascular–liver–metabolic disease syndemic to illustrate current and future projections on the burden of these diseases and their risk factors, and propose a unified framework for integrating and implementing effective multisystem interventions to tackle key components of this syndemic.

New online! The global cardiovascular–liver–metabolic syndemic: epidemiology, trends and challenges #CardioSky

The cutting-edge medical approaches that could transform ageing An optimistic take on the state of the longevity field provides hope for treating a range of ageing-related diseases — but feels at odds with the current shape of US research.

Book review 📚 The cutting-edge medical approaches that could transform ageing

go.nature.com/46Fu2Sp

Inhibition of integrin alpha V reduces inflammation and the transition to heart failure after pressure overload Integrin alpha V (CD51) is a surface receptor that binds to extracellular matrix ligands and contributes to fibrotic responses, including post-infarct…

Pr JS Hulot team @PARCC revealed that CD51 contributes to the immune-fibrotic axis driving heart failure progression under pressure overload.
www.sciencedirect.com/science/arti...

Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.

doi.org/10.1016/j.kint.2025.07.037

#OpenAccess #NephSky #MedSky #CKD #FSGS #chronickidneydisease @parcc-inserm.bsky.social @rwth.bsky.social

Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System | Circulation Background: Porcine genome editing has revolutionized xenotransplantation, recently enabling the first pig-to-human heart xenotransplants. However, the xeno-immune response in heart xenografts remains...

Team Loupy@PARCC characterizes the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System | Circulation www.ahajournals.org/doi/10.1161/...

Dexamethasone Suppresses Endotheliopathy and Endothelial-Induced Coagulopathy in COVID-19 | Arteriosclerosis, Thrombosis, and Vascular Biology BACKGROUND: Endotheliopathy and coagulopathy are known complications of COVID-19, with a significant association with mortality. Although dexamethasone is the standard of care for patients with severe...

🚨 New paper from the lab in ATVB

Dexamethasone protects against COVID-19 endothelium-induced coagulopathy 🦠🔥🫁🩸

@davidmsmadja.bsky.social @hopitalpompidou.bsky.social @upcite.bsky.social @parcc-inserm.bsky.social
@ahajournals.bsky.social
@inserm.fr

www.ahajournals.org/doi/10.1161/...

Inspiring and fun meeting with outstanding @rkramann.bsky.social at the @parcc-inserm.bsky.social #Masterclass @olilen.bsky.social with the community, #our KVIM team and young early career researchers ! Thank you Rafael!

D Smadja team @PARCC shows that Dexamethasone Suppresses Endotheliopathy and Endothelial-Induced Coagulopathy in COVID-19 | Arteriosclerosis, Thrombosis, and Vascular Biology www.ahajournals.org/doi/10.1161/...

Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. Focal segmental glomerulosclerosis (FSGS) is a common histological lesion in adults worldwide. It results from initial podocyte injury, followed by a maladaptive activation of glomerular parietal epit...

PL Tharaux team and MC Zennaro team @PARCC show that mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis. - Kidney International www.kidney-international.org/article/S008...

KLK15 alters connective tissues in hypermobile Ehlers-Danlos syndrome Body system; Non-infectious disease; Biological process; Molecular genetics

N Bouatia-Naji and T Berrandou @PARCC participate to a study showing that KLK15 alters connective tissues in hypermobile Ehlers-Danlos syndrome: iScience www.cell.com/iscience/ful...

This AI tool predicts your risk of 1,000 diseases — by looking at your medical records Hear the biggest stories from the world of science | 7 September 2025

This week on the Nature Podcast 🔊 This AI tool predicts your risk of 1,000 diseases — by looking at your medical records

go.nature.com/46rd492

People are more likely to cheat when they delegate tasks to AI Artificial intelligence is moving from being a mere tool to an active partner in decision-making, but when we offload misconduct to machines, who bears the blame?

And LLMs are more likely than a human intermediary to comply with prompts that promote cheating

go.nature.com/3VnGUpG

"... checking citations is just as important as carrying out experiments ..." - H. Holden Thorp, Editor of Science journals.

"Treating careful scholarship as somehow less important than the acquisition of data can adversely affect the reliability of the scientific record and consequently, the course of science," writes H. Holden Thorp in a new #ScienceEditorial. https://scim.ag/4mqrKet

From 24 to 26 September 2025, Pr RM Bruno and Pr N Bouatia -Naji from PARCC will participate to the third edition of the Women’s Health Conference. This event will gather global leaders in women’s health to drive progress and foster international dialogue.
iwish.u-pariscite.fr/events/event...

Please join us for our Interdisciplinary Conference on Women's Health at Université Paris Cité on 24-26 September! @upcite.bsky.social @echelles-umr8264.bsky.social @institutcochin.bsky.social @ludivinedoridot.bsky.social @OPPaLE-inserm @parcc-inserm.bsky.social @Ceped IRD

Heart failure improvement, remission, and recovery: A European Journal of Heart Failure expert consensus document Different scenarios of left ventricular ejection fraction (LVEF) trajectories in heart failure (HF) with mildly reduced and reduced ejection fraction patients. impHF, improved heart failure; LV, left...

Pr. JS Hulot @PARCC and colleagues provide expert consensus document which delineates Heart Failure (HF) trajectories, examines factors reflecting HF improvement beyond recovery of LVEF, and explores the prognostic implications of these phenotypic transitions.
doi.org/10.1002/ejhf...

Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection Nature - Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.

In a medical first, researchers report that they have implanted CRISPR-edited pancreas cells into a person with type 1 diabetes

go.nature.com/46paWQ0

Maladie thromboembolique veineuse : prédire le risque de récidive grâce à la génétique - Salle de presse de l'Inserm Troisième cause de mortalité cardiovasculaire, la maladie thromboembolique veineuse résulte de la formation d’un caillot pouvant bloquer la circulation sanguine dans une veine et provoquer des complic...

Maladie thromboembolique veineuse : prédire le risque de récidive grâce à la génétique

Lire le communiqué : presse.inserm.fr/maladie-thro...

Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis Nature Reviews Cardiology, Published online: 05 September 2025; doi:10.1038/s41569-025-01205-3In this Review, Porrello and colleagues describe the origins of the fetal gene hypothesis and discuss the evolution of this hypothesis by considering more recent evidence from genome-wide sequencing studies.

New online! Transcriptional regulation in heart development, disease and regeneration: reassessing the fetal gene hypothesis #CardioSky

PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations | Circulation BACKGROUND: Hereditary hemorrhagic telangiectasia is an inherited vascular disorder characterized by arteriovenous malformations (AVMs). Loss-of-function variations in activin receptor-like kinase 1 (...

Pr. A Eichmann and colleagues @PARCC and @Yale University School of medicine unravel that PIEZO1 blockade reduces arteriovenous malformations formation and alleviates cellular and molecular hallmarks of ALK1-deficient cells.
doi.org/10.1161/CIRC...

Collaborative work from E Camerer @PARCC highlights S1PR1 as a new regulator of both lymphatic valves and tertiary lymphoid organs (TLOs), and suggests that TLOs could be a marker for underlying lymphatic disorders.
doi.org/10.1084/jem....