Lord Mel von Castello

What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social

rupress.org/jcb/article-...

Mapa del robo extractivo y en consecuencia del sometimiento de los pueblos africanos por parte de las antiguas metrópolis y los nuevos agentes neocoloniales.

A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1 - Nature Chemical Biology High-content protein arrays were used to identify cysteine dioxygenase (CDO1) as a small-molecule glue target for the von Hippel–Lindau (VHL) E3 ubiquitin ligase and induces VHL-dependent proteasomal ...

Cysteine dioxygenase (CDO1) is identified as a small-molecule glue target for the von Hippel-Lindau (VHL) E3 ubiquitin ligase and induces VHL-dependent proteasomal degradation of CDO1 in cells

www.nature.com/articles/s41...

‘Killswitch’ protein lets scientists study immobilized cellular droplets Synthetic peptide fixes biomolecular condensates, revealing how these enigmatic cell structures actually work.

Scientists have found a way to jam the inner workings of biomolecular condensates, revealing how these enigmatic cell structures actually work

https://go.nature.com/44f4bOO

Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue - Nature Metabolism Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs thermogenesis.

RESEARCH | ‪@dylanduerre.bsky.social @andreagalmozzi.bsky.social‬ et al. - ‪@uwmadison.bsky.social‬

Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which impairs #thermogenesis 🐁🌡️

www.nature.com/articles/s42...

High-resolution imaging of RNA and proteins in thick tissues using cycleHCR Nature Reviews Genetics, Published online: 28 May 2025; doi:10.1038/s41576-025-00860-zIn this Tools of the Trade article, Jun Kim and Zhe Liu describe cycleHCR, a method that enables researchers to simultaneously detect several different RNA and protein molecules at high-resolution across tissues.

ICYMI: New online! High-resolution imaging of RNA and proteins in thick tissues using cycleHCR

Mary Morris descubrió que la radiación podía afectar a los cromosomas de distintas maneras, así como reducir la fertilidad de las plantas y su cantidad de semillas.
https://mujeresconciencia.com/2025/05/22/mary-rosalind-morris-la-genetista-que-sustituia-cromosomas-en-el-trigo-para-ver-que-cambiaba/

Unravelling cysteine-deficiency-associated rapid weight loss - Nature Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

Nature research paper: Unravelling cysteine-deficiency-associated rapid weight loss

https://go.nature.com/4mpetns

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Multigenerational cell tracking of DNA replication and heritable DNA damage

Congrats @altmeyerlab and collaborators

www.nature.com/articles/s41...

Quality assurance of segmentation results - FocalPlane Quality assurance of segmentation results - Bio-image Analysis with Napari

I regularly point collaborators at this segmentation quality assurance blog post by @marabuuuu.bsky.social , because some scientists get trapped in a segmentation-improvement-loop without ever measuring how good an algorithm actually is. focalplane.biologists.com/2023/04/13/q...

Functional synonymous mutations and their evolutionary consequences Nature Reviews Genetics, Published online: 20 May 2025; doi:10.1038/s41576-025-00850-1Synonymous mutations, once deemed neutral, have been shown to influence gene expression and organismal fitness by affecting transcription, mRNA processing, translation and protein folding. In this Perspective, the authors highlight evidence for fitness effects of synonymous mutations and discuss resulting implications for evolutionary and disease genetics.

New online! Functional synonymous mutations and their evolutionary consequences

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival - Cancer & Metabolism Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent...

New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10....

A universal AI-powered pipeline enables precise 3D analysis of cell morphology and topology within organoid structures.

www.nature.com/articles/s41...

Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membr...

New paper out! Would you like to fluorescently label the plasma membrane in live, fixed or permeabilized cells? I tested different lipid structures and labelling approaches to decide what makes a good membrane labelling probe for such imaging experiments!
www.biorxiv.org/content/10.1...

For a quick summary of the paper, read the Research Briefing here:
www.nature.com/articles/s41...

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

The do’s and don’ts of scientific image editing

www.nature.com/articles/d41...

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution - Nature Communications Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour ...

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

We are excited to present our latest work published in @natcomms.nature.com

www.nature.com/articles/s41...

A glass of beer sits on a wooden table. While lagers were first fermented in Europe, one of the yeasts required to brew them originated in South America. Image credit: photokirov/Shutterstock.

Bavarian blonde #beers may trace their origins to #Patagonia. In PNAS Journal Club: www.pnas.org/post/journal...

#yeast #Bavaria #beer #fermentation

Using single-molecule imaging and super-resolution microscopy, Isogai et al. reveal that all extracellular vesicle subtypes derived from four distinct tumor cell lines, regardless of size, bind to laminin predominantly via CD151-facilitated integrin heterodimers and GM1 rupress.org/jcb/article/...

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

The do’s and don’ts of scientific image editing

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

@sarareardon.bsky.social reports

www.nature.com/articles/d41...

Una ‘Escuela de rehenes’ o cómo Francia usó la educación en África para transformar las mentes La administración colonial francesa puso en marcha en 1855 un centro educativo que tenía el objetivo de formar a los hijos de los reyes locales mediante el borrado de su cultura.

En 1855 la administración colonial francesa abrió L’ École des otages con el fin de convertir a los hijos de los reyes locales en agentes al servicio de la metrópoli.
✍️ @aliciajusto.bsky.social 

Curved light sheet microscopy for centimetre-scale cleared tissue imaging - Nature Photonics Light sheet microscopy with curved light sheets enables tiling-free imaging of an entire intact cleared mouse brain with lateral and axial spatial resolutions of 1.0 μm and 2.5 μm, respectively, in le...

Curved light-sheet microscopy
www.nature.com/articles/s41...

Spain’s Far-Right Resurgence Comes From Decades of Fascist Organizing In recent decades, Spain has often been painted as the only European country without a far right. But even in the 1990s, violent street movements were building their forces — and now they’re entering ...

32 anys amb Guillem Agulló. Charlé con @miquelramos.bsky.social en la estadounidense Jacobin.
"A veces me preguntan si el antifascismo ha fallado. Diría que no. La cuestión es por qué se dejó sola a gente, mucha de ella muy joven, que luchó contra la extrema derecha".
jacobin.com/2022/08/spai...

Spatial multi-omics reveals cell-type-specific nuclear compartments - Nature A genomic barcoding scheme called two-layer DNA seqFISH+ enables the simultaneous mapping of more than 100,000 loci and has been used to identify cell-type-specific subnuclear compartments in the mouse brain.

Nature research paper: Spatial multi-omics reveals cell-type-specific nuclear compartments

https://go.nature.com/4jngJJB

Uridine-sensitized screening identifies genes and metabolic regulators of nucleotide synthesis

www.biorxiv.org/content/10.1...

Magnífic!

Super excited about this fantastic study by my friend Johan Garaude in @nature.com. His team found that macrophages recycle carbon from engulfed bacteria, fueling their own metabolism in a highly regulated process. 👏
Grateful to have contributed a tiny part.
www.nature.com/articles/s41...

iMetAct: An integrated systematic inference of metabolic activity for dissecting tumor metabolic preference and tumor-immune microenvironment Wang et al. present iMetAct, a computational method that integrates information propagation and enrichment analysis to infer metabolic enzyme activity from gene expression data. Applying iMetAct to HC...

iMetAct: An integrated systematic inference of metabolic activity for dissecting tumor metabolic preference and tumor-immune microenvironment

www.cell.com/cell-reports...

Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kinetics Deuterium metabolic imaging quantitatively maps glycolytic and mitochondrial oxidation fluxes in mouse glioblastoma and their association with tumor histopathologic features.

Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kinetics

elifesciences.org/articles/100...