Christoph Heuser-Loy

Jo in our team - we are looking for a PhD student, postdoc or lab manager!

More information and links to job portal for application submission:

lnkd.in/dcU2Vg7W

lnkd.in/dgVKTARV

Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity - Nature Biotechnology T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.

This is interesting for a number of reasons. www.nature.com/articles/s41...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.

Want to get a tough sample, like lung, looking like this? Read more!

www.biorxiv.org/content/10.1...

Targeting organelle function in T cells for cancer immunotherapy - Nature Reviews Immunology In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and how this knowledge is being used to power the next generati...

A Review article by Jeremy Baldwin, @cheuserloy.bsky.social & Luca Gattinoni discusses emerging strategies to modulate #organelle functions — including the transfer or transplantation of native or synthetic organelles — that could enhance #cancer #immunotherapy.
#immunosky

Open position! The group of Kaan Boztug at the Clinic for Pediatric Immunology and Rheumatology in Bonn is looking for a

Postdoc in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 %) for inatially 7 years.

More information on our website: www.immunosensation.de/opportunitie...

Organelle fitness ➡️ cell fitness
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x

Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...

New #flowcytometery protocol drop from Oliver Burton.

This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.

currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Versatile and efficient non-viral integration of large transgenes in human T cells via CRISPR knock-in and engineered integrases Current gene transfer methods often lack the precision, versatility, or efficiency when integrating large transgenes, limiting the ability to engineer therapeutic T-cells with more complex payloads. H...

You like engineering T cells, but you are missing the right flavor?

Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1

We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt
𝐏rogrammable
𝐀nd
𝐒ite-specific
𝐓ransgene
𝐀ddition
🧪

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

Applications for postdocs (MD/PhD) to the Mildred Scheel School of Oncology are open: msso-cologne-bonn.de/application
👩‍🔬 Check out the opportunities in the Cologne-Bonn cancer research hub in the heart of Europe! 🌍

🚨 Open #position! The group of Zeinab Abdullah is looking for two PhD students for

a) Characterisation of hepatic NK-like T cells

b) Dissecting the role of STING signalling in anti-viral T cell responses

Application deadline: October 30

More information: www.immunosensation.de/opportunitie...

🧵How to write and manage your first research budgets

The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

I could not get myself to watch it but hopefully this inspires others to pursue immunology! Follow your curiosity folks and don't let the current leadership discourage you, tides ebb and flow - we are ultimately on the right boat. cheers

Gradually for sure, kicking in (long) before reaching PI status if you ask me...

🚨 There is a new W2 Professorship for Tumor Immunology (permanent position) available in our department. 🎓 🧫 🧪 🔬

ℹ️ Check out the details here: www.uni-bonn.de/en/universit...

⏰ Apply now! Application deadline is August 26, 2025.

📢 Please share!

@unibonn.bsky.social @immunosens.bsky.social

Naive T cell vs Killer T cell

European Championship: How to Deutsche Bahn Foreign football fans beware: riding the train in Germany is, uh, speziell. If you want to survive, here is what you need to know.

It was fitting more often than not last year, from my experience www.zeit.de/mobilitaet/2...

<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...

Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13

onlinelibrary.wiley.com/doi/10.1111/...

🚨 Open #position! The group of Christoph Wilhelm at the University Hospital Bonn is looking for a

Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity

Application deadline is February 10!

Visit our website for more information.

#job #postdoc #science #immunology

The Wild West of spike-in normalization - Nature Biotechnology The proper use of spike-in normalization in ChIP-seq improves sensitivity for detecting genome-wide changes between conditions, but improper use is common, calling some biological conclusions into que...

An excellent review on spike-in normalization in ChIP-seq. When done correctly, spike-in is a vast improvement in quantitation. However best practices are non-obvious. Suboptimal design & analysis are shown to lead to erroneous conclusions in the literature. www.nature.com/articles/s41...

Hidden among our immune system's seeds, scientists found special ones that could revolutionize cancer treatments and vaccines.

@deekshadeep @danapeer.bsky.social @jexpmed.bsky.social

t.co/k5lwZHxzxi
#ImmunoSky 🧪

T cells lead the charge against solid tumors - Nature Cancer In 2024, two groundbreaking approvals from the US Food and Drug Administration for T cell-based therapies that target solid tumors were achieved. Lifileucel, a polyclonal tumor-infiltrating lymphocyte...

🔭 What’s in store next for cell therapy for solid tumours?

2024 has been seismic with the @fda.gov approval of Lifileucel (melanoma) & Afami-cel (sarcoma).

Check out this outlook piece out today in Nat Cancer by Kishton & Restifo 👇

@natureportfolio.bsky.social

www.nature.com/articles/s43...

1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1

Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery ... Biologics can be specifically delivered to T cells by genetically engineering cells to secrete extracellular vesicles that actively load protein cargo and that display high-affinity T-cell-targeting d...

VERY excited to welcome this paper out in @natBME where we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles
www.nature.com/articles/s41...

Tauchsieder: Die Bonner Bubble-Republik Der Betrieb in Berlin kreist seit dem Ampel-Aus um die Parteien der alten Bundesrepublik – argumentiert und berichtet an einem Drittel der Wähler vorbei. Das könnte sich rächen. Eine Kolumne.

Der Betrieb in Berlin kreist seit dem Ampel-Aus um die Parteien der alten Bundesrepublik – argumentiert und berichtet an einem Drittel der Wähler vorbei. Das könnte sich rächen. Eine Kolumne.

Great meeting, great science! Thank you for bringing everyone together @kischober.bsky.social

Would be great if you could add me, too 😃

Cancer escapes immunotherapies by mutating its surface, meaning even groundbreaking #CARTCell therapies fail too often. But what if #GenerativeAI could design CAR-T with de novo binders faster, targeting resistant tumors? 🧵 www.biorxiv.org/content/10.1... (1)

Looking forward to expanding the network here. Let's paint the #immunosky with more stars!