Sebastian Bruchmann

Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine cover... Thomas Stanton and colleagues use whole genome sequencing to evaluate the prevalence of Klebsiella pneumoniae K and O antigen types in 13 countries in Africa and South Asia to help inform vaccine desi...

This is the sort of strategic planning that should go into #vaccine design 💉

They analysed 1,930 #Klebsiella pneumoniae 🦠🧫🧬 neonate blood isolates from 13 countries and estimate that 20 antigens 🧪 could cover 72.9% of all infections for 5–10 years

#IDSky #EpiSky

journals.plos.org/plosmedicine...

🔊 Job Opportunity: Postdoctoral Research Fellow in Bacterial Evolution.

Looking to recruit a postdoc to join a UKRI FLF-funded project on antibiotic resistance evolution in the microbiome 🦠

3 years funding, deadline 26th Jan, please share!
hrwebapp.qub.ac.uk/tlive_webrec...

Life Identification Numbers: A bacterial strain nomenclature approach Unified strain taxonomies are needed for the epidemiological surveillance of bacterial pathogens and international communication in microbiological research. Core genome multilocus sequence typing (cg...

Huge preprint if you are interested in bacterial strain taxonomy! The why and how of cgMLST LIN codes: An extensively revised and expanded version doi.org/10.1101/2024... I will summarize it for you in this thread 👇

The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com

New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...

We are hiring! 🎓🧫 🧬

#PhD studentship available in #Immunology at #CambridgeUniversity to investigate a new killer function of human T cells.

📅 Application deadline: 3rd December 2025
more information: lnkd.in/dxq6yMay
#findaPhD @ERC_Research

University of Cambridge The University of Cambridge is one of the world’s leading universities, with a rich history of radical thinking dating back to 1209.

I know of an untouched copy of the library here in Cambridge. It should be possible to access it but can't promise anything, unfortunately. Please drop me an email if you're interested in it - shgb2 at cam.ac.uk

🚨 Another funded PhD alert🚨

We are recruiting again! For a PhD student to start with us in the @langridgelab.bsky.social October 2026 - please share 👀

If you are interested in foodborne pathogens, public health and phage, look no further 🦠🏥🧬

➡️ tinyurl.com/3zvavp2t ⬅️

Apply by 6 Jan 2026 🗓️

The authors here present Dual Tn-seq, a method combining randomly barcoded transposon insertion sequencing (RB Tn-seq) with Cre-lox recombination, to generate and assay double mutants en masse.
The method looks great - congratulations to all involved!

Transposon insertion sequencing (Tn-seq / TraDIS) lets us identify essential genes and, in principle, study genetic interactions (epistasis). But in bacteria, doing this at scale is hard.

Fantastic paper: "Dual transposon sequencing profiles the genetic interaction landscape in bacteria" out now in Science www.science.org/doi/10.1126/...

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

OK, here it is. Come work with me at the University of Liverpool making ALL THE AI models from ALL THE prokaryote pangenome data. Heck, we will make models from ALL the pangenomes, even eukaryotes!!! (link below👇) 1/4

PLEASE RETWEET.

Come and work with Nicole Stoesser and I in Oxford with the fantastic team @modmedmicro.bsky.social - great opportunity for a postdoc in microbial genomics to do some creative research with great datasets as part of our HPRU.

my.corehr.com/pls/uoxrecru...

I haven't done this in E. coli, but in Pseudomonas the attTn7 site via mini-Tn7 transposon integration worked well.

Me (Sebastian Bruchmann) giving a presentation titled "Towards a scalable platform for high-throughput virulence assays"

Had a brilliant time in Liverpool at Edge Hill University for the Galleria mellonella Workshop 🐛
Grateful to be invited as a speaker, the great chats and new connections. Amazing to see the wide range of applications, hope our time lapse imaging work can add to the field!

Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...

Wow - that is amazing! Many, many congratulations 👏🥳

Many, many congratulations Caity - so excited for you 🎉🥳

Many congratulations! 🎉
I've been using them for a while now and still can't believe how bright they are. Fantastic work! 👏

Our latest preprint is out describing amr.watch - a platform for monitoring AMR trends from global genomics data: www.biorxiv.org/content/10.1... (1/6)

Phage therapy for Klebsiella pneumoniae: Understanding bacteria–phage interactions for therapeutic innovations Klebsiella pneumoniae (KP) is a Gram-negative bacterium that commonly resides in the human gastrointestinal tract and can also act as an opportunistic pathogen and cause extra-intestinal infections. K...

Our review on recent advances in #PhageTherapy against Klebsiella pneumoniae is out!
We analyze KP-phage interactions from an eco-evo perspective, summarize many lab and clinical trials, and discuss novel approaches like genetic engineering & machine learning.
#microsky
doi.org/10.1371/jour...

GitHub - avantonder/bacQC-ONT: QC pipeline for ONT data QC pipeline for ONT data. Contribute to avantonder/bacQC-ONT development by creating an account on GitHub.

I've spent some time updating my two Nextflow-based bacterial QC pipelines (bacQC and bacQC-ONT). It'd be great to get some feedback.
github.com/avantonder/b...
github.com/avantonder/b...

Wellcome Connecting Science in partnership with FutureLearn Bioinformatics for Biologists online course suite Starts February 2025 Course one: An introduction to Linux, Bash Scripting, and R Join the social conversation using this hashtag: #FLLinuxForBioinformatics Course two: Analysing and Interpreting Genomics Datasets Join the social conversation using this hashtag: #FLAdvancedBioinformatics Bridge the gap between biology and computational science Available on-demand until February 2026

Free #bioinformatics toolkit for #biologists!

Master #Linux, basic scripting, and advanced Nextflow pipelines, with our #OnlineCourses that guide you through complete bioinformatics workflows.

Gain deeper insights from your biological research🚀

📎 Info: bit.ly/4aMV22B

Brochado and Maier labs in Germany are looking for a PhD student to study horizontal gene transfer in bacteria. ENDAMR Marie Curie doctoral network (endamr.eu) - an amazing opportunity to work with top scientists in the field all around Europe!
www.cmfi.uni-tuebingen.de/mariecuriephd

We’ve just released a public Pathogenwatch collection of the MRSN Diversity Panel comprising 100 diverse K. pneumoniae clinical isolates: pathogen.watch/collection/8... #KlebClub

Research Associate in Experimental Evolution:Manchester

🚨 Job alert 🚨 — are you interested in understanding how mobile genetic elements and defence systems shape bacterial genome evolution? 🧬 🧪 🧫 🦠 2x 5-year research positions available in experimental evolution @mermanchester.bsky.social Join us! #microsky
www.jobs.manchester.ac.uk/Job/JobDetai...

Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in gram‐negative bacteria CprA is a short-chain dehydrogenase/reductase (SDR) that contributes to resistance against colistin and antimicrobial peptides. The cprA gene is conserved across Pseudomonas aeruginosa clades and its....

✨ Excited to share our work in the Journal of Extracellular Vesicles! ✨ We reveal a new family of virulence factors in gram-negative bacteria like P. aeruginosa that drive harmful OMV production. 🦠
isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

Sie suchen #Infektionsforscherinnen? Wir haben ein #StarterPack mit allen Infect-Net-Wissenschaftlerinnen auf BlueSky zusammengestellt:
🇬🇧 Curious about contributions of women in #infection research? We put together a StarterPack with all our Infect-Net experts on BlueSky 🦋
👉 go.bsky.app/JU8KaeQ

Great collection of papers on adaptive evolution of AMR