Can leaf MICROBES help protect MAIRE TAWAKE from MYRTLE RUST? In our next Rangahau Rising kΕrero @hanareiaehau.bsky.social shares research into the microbiome of this endangered tree and what it could mean for forest resilience in Aotearoa
Wed 20 Aug | 12β1 PM | Zoom
π Register: tinyurl.com/25x2jwae
05.08.2025 21:47 β π 5 π 4 π¬ 1 π 1
Group Leader β Molecular Systems Biology Unit
Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...
Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!
30.07.2025 15:14 β π 71 π 78 π¬ 1 π 1
π¦ π§ββοΈFrom bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
24.07.2025 18:22 β π 258 π 121 π¬ 9 π 11
1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77
24.07.2025 19:58 β π 70 π 35 π¬ 3 π 1
π Exciting news! Weβre launching three fully-funded postdoc positions for "New Horizons for Synthetic Phagesβ
Join us in tackling antimicrobial resistance with cutting-edge synthetic biology + AI bioinformatics. Based at Flinders Uni in vibrant Adelaide.
π Read on for details!
#Phage
25.07.2025 08:15 β π 46 π 41 π¬ 2 π 1
A new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity.
www.biorxiv.org/content/10.1...
17.07.2025 20:38 β π 54 π 28 π¬ 2 π 3
Astounding new structure of a nucleotide immune signal degrading enzyme. The field has found enzymes with this function that look like nucleases, enzymes that look like nucleotide binding proteins, even enzymes that look like proteases... but never a fold like this!
www.biorxiv.org/content/10.1...
18.07.2025 17:28 β π 6 π 1 π¬ 0 π 0
Preprint: βStructural modeling reveals viral proteins that manipulate host immune signalingβ
Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules
Congrats Nitzan Tal!
www.biorxiv.org/content/10.1...
14.07.2025 07:36 β π 78 π 34 π¬ 1 π 0
SAM-AMP lyases in type III CRISPR defence
Abstract. Type III CRISPR systems detect non-self RNA and activate the enzymatic Cas10 subunit, which generates nucleotide second messengers for activation
Here we show how the type III signalling molecule SAM-AMP is bound and degraded by a specialised lyase enzyme encoded in cellular and phage genomes. More great work by @haotianchi.bsky.social and the team. @uniofstandrews.bsky.social
academic.oup.com/nar/article/...
14.07.2025 11:07 β π 38 π 19 π¬ 1 π 1
It's been a great few days hosting Eugene Koonin in St Andrews @uniofstandrews.bsky.social , where he was awarded an honorary degree in recognition of his stellar contributions to molecular biology and comparative genomics. Here with @tatianadimitriu.bsky.social
04.07.2025 09:02 β π 47 π 5 π¬ 2 π 0
Great to see this comprehensive work on phage DNA arabinosylation & defense finally out! π§¬π«βοΈ A major collaborative effort & stellar PhD work by Marina Mahler, whom I had the pleasure of co-supervising at Otago π©π»βπ¬ @peterfineran.bsky.social @universityofotago.bsky.social @cellpress.bsky.social #mm
26.06.2025 22:44 β π 8 π 1 π¬ 0 π 0
Thanks @vivekmutalik.bsky.social!
28.06.2025 08:40 β π 1 π 0 π¬ 0 π 0
Great collaboration with Suzanne Warring, Hazel Sisson @peterfineran.bsky.social and others to combat kiwifruit canker via an endolysin-lipase chimera, grateful to be involved, check it out here: www.jbc.org/article/S002...
13.05.2025 07:38 β π 3 π 2 π¬ 0 π 0
Really excited to share our resource and analysis of AlphaFold-predicted monomers and homodimers across viruses and phages. Project driven by fab PhD student @rodai.bsky.social and with our great collaborators Joana Pereira @joanampereira.bsky.social and @ninjani.bsky.social
19.05.2025 06:37 β π 66 π 33 π¬ 0 π 1
I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!
18.05.2025 15:19 β π 85 π 79 π¬ 3 π 2
Out in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage
Joint work with the TamulaitienΔ and Kranzusch labs
www.nature.com/articles/s41...
Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
30.04.2025 18:44 β π 87 π 43 π¬ 2 π 1
A beautiful discovery by Joel Tan and Philip Kranzusch, out today in Nature:
A DNA-gated molecular guard controls bacterial Hailong anti-phage defence
Congrats Joel and Philip! Was a pleasure to contribute to this discovery together with Sarah Melamed
www.nature.com/articles/s41...
30.04.2025 18:59 β π 54 π 20 π¬ 1 π 1
PhD position available - plant-microbe-pollinator interactions in Kowhai flowers! With myself & Prof Jacqueline Beggs, based at Manaaki Whenua, Lincoln. Details below, or DM me! @microbiologysociety.org @evoldir.bsky.social @aucklanduni.bsky.social @microbiologynz.bsky.social
30.04.2025 23:03 β π 7 π 8 π¬ 1 π 1
New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
16.04.2025 07:14 β π 99 π 126 π¬ 2 π 1
Amazing committee who helped organise everything including @bridgetwatson.bsky.social @dsashital.bsky.social and @knottrna.bsky.social
12.04.2025 21:42 β π 2 π 0 π¬ 0 π 0
Bioinformatician at the New Zealand Institute for Bioeconomy Science | Helping improve agriculture in Aotearoa New Zealand π³πΏ | π¨π¦ πͺ π₯ π§¬
CryoEM, Structural Cell Biology. Group Leader@University of Melbourne. #NHMRC Emerging Leadership Fellow. Formerly at @Caltech, @MRC_LMB.
PhD student at Trevor Lithgow's group Monash BDI. Facultative bioinformatician who in love with phages and their dark matters.
Assistant Professor at University of Florida College of Medicine
PhD Candidate in the Fineran Lab - studying the type I-D CRISPR-Cas system π¦ π©πΌβπ¬
πUniversity of Otago, Dunedin, NZ π³πΏ
Multidisciplinary enthusiast | #Bioinformatics #NetworkScience #AMR #R #SysBio #DataScience #ML #AI
Harvard Medical School, Dana Farber Cancer Institute
https://kranzuschlab.med.harvard.edu
Assoc Prof of Teaching at UC Davis. Hypermicrobiophile (impossible to pick a favorite!) and learning enthusiast. Opinions are my own and updated with new data. she/her/hers
Professor at University of Otago, NZ; Webster Chair in Virology; Rutherford Discovery Fellow. I like viruses and evolution.
Doctoral researcher in microbiology
Researching large phages & viral ecology
Passionate about virology, microbial ecology, and the world of viral-bacterial interactions
University of JyvΓ€skylΓ€, Finland
Relaying microbiology news, articles and comments relevant to aspects on bacteria, fungi, viruses and other microbes / microorganisms. Microbes are πͺ
Department of Microbiology and Immunology at the University of Otago
Assistant prof at UCI School of Medicine | Molecular mechanisms of gene editors & Engineering precision editing tools to fix genetic diseases | CRISPR, structure, biochemistry
Assistant Professor of all things fungi, from their nifty viruses to their inevitable demise π @NSfungiLab @HUJIAgri
PhD student at the University of JyvΓ€skylΓ€
Interested in Phage-Bacterium-Host Interactions π§¬π©βπ¬
Believer of Open Science
Supporter of Phage Therapy
Scientist | Collaborative Leadership Consultant for STEM Leaders and Organizations at BridgUs Lab
NOT SPAM. But I was reported and nothing I can do. So this account will be inactive: find me on LinkedIn, the only platform working well.
At least the bots can flourish here. Sigh.
Director General/
Natural Resources Canada
Professor, Biology, Indiana University
Bacterial physiology and cross-feeding interactions
Artist: https://bit.ly/3oy86jf
Sheltering under solar panels.
Posts are my own.
PhD student studying phage-host interactions at ETH ZΓΌrich | Lab of Molecular Phage Biology
postdoc at van Houte lab, University of Exeter
