Peter Fineran

Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...

Interested candidates are encouraged to contact me via email for further details.

@spp2330.bsky.social; @mibinet.bsky.social

The ISVM logo for the International Society for the Viruses of Microorganisms

Welcome @isvm-society.bsky.social to bsky, the International Society for the Viruses of Microorganisms. Check the new look website isvm.org and become a member for free!

#phagesky #microsky

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost

Assistant Professor Plant-Microbe Interactions We seek a creative, collaborative, and visionary plant biologist to establish an internationally recognized research program at the forefront of plant-microbe interactions aimed at understanding how t...

The Department of Biology at Colorado State University is hiring an Assistant Professor in the area of plant-microbe interactions! Please spread the word!

jobs.colostate.edu/postings/165...

Type I CRISPR-Cas immunity primes type III spacer acquisition Smith and Fineran describe how priming by type I CRISPR-Cas systems facilitates adaptation and spacer maintenance by a co-occurring type III system, which normally induces abortive infection. While ty...

Type I CRISPR-Cas immunity primes type III spacer acquisition

Priming by type I CRISPR-Cas aids spacer maintenance by co-occurring type III. Concurrent DNA&RNA-targeting minimize phage escape for population benefit

@peterfineran.bsky.social @leahmsmith.bsky.social
www.cell.com/cell-host-mi...

All systems go: CRISPR crosstalk for enhanced immunity In this issue of Cell Host & Microbe, companion manuscripts from Margolis & Meeske and Smith & Fineran demonstrate that CRISPR-Cas systems have an unprecedented level of cooperative crosstalk between ...

All systems go: CRISPR crosstalk for enhanced immunity

Barrangou Previews papers led by @peterfineran.bsky.social & Meeske demonstrating CRISPR-Cas systems have unprecedented level of cooperative crosstalk between different subtypes, enabling primed spacer acquisition
www.cell.com/cell-host-mi...

Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...

We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.

Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!

Translational coupling of neighboring genes in prokaryotes | Journal of Bacteriology Prokaryotic genes are arranged in operons, with functionally related genes often located adjacent to one another (1). There are several ways in which the operonic organization of genes facilitates the...

Check out our new paper: a review of translational coupling, the phenomenon where translation of one prokaryotic gene can promote translation of the gene downstream. We cover the history, and delve into the mechanism, which is still not fully understood. journals.asm.org/doi/10.1128/...

Programmable antisense oligomers for phage functional genomics - Nature Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagatio...

No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence.
@jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social
@uni-wuerzburg.de @helmholtzhzi.bsky.social
published now in @nature.com

Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...

Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...

The ecology and evolution of bacterial immune systems'.

#phage #phagesky

A bunch of interesting reviews

royalsocietypublishing.org/doi/10.1098/...

Thanks Ákos!

Phage defence-system abundances vary across environments and increase with viral density | Philosophical Transactions of the Royal Society B: Biological Sciences The defence systems bacteria use to protect themselves from their viruses are mechanistically and genetically diverse. Yet the ecological conditions that predict when defences are selected for remain ...

Phage defence-system abundances vary across environments and increase with viral density

Phil. Trans. R. Soc. B by @seanmeaden.bsky.social, Edze Westra and @peterfineran.bsky.social

royalsocietypublishing.org/doi/10.1098/...

@leahmsmith.bsky.social

Type I CRISPR-Cas immunity primes type III spacer acquisition Smith and Fineran describe how priming by type I CRISPR-Cas systems facilitates adaptation and spacer maintenance by a co-occurring type III system, which normally induces abortive infection. While ty...

Type I CRISPR-Cas immunity primes type III spacer acquisition

Priming by type I CRISPR-Cas aids spacer maintenance by co-occurring type III. Concurrent DNA&RNA-targeting minimize phage escape for population benefit
@leahmsmith.bsky.social‬ ‪@peterfineran.bsky.social‬
www.cell.com/cell-host-mi...

@leahmsmith.bsky.social

Type I CRISPR-Cas immunity primes type III spacer acquisition CRISPR-Cas systems are diverse, with microbes harboring multiple classes and subtypes. Type I DNA-targeting and type III RNA-targeting systems often c…

In a multi-CRISPR-Cas system host, @peterfineran.bsky.social & I found that type I priming promotes spacer 🧬 uptake & maintenance by a type III system & that multiple systems minimize phage escape ⬇️ @cp-cellhostmicrobe.bsky.social @otagomicroimmuno.bsky.social
www.sciencedirect.com/science/arti...

Thanks @cp-cellhostmicrobe.bsky.social

Crosstalk between three CRISPR-Cas types enables primed type VI-A adaptation in Listeria seeligeri CRISPR-Cas systems confer adaptive immunity to their prokaryotic hosts through the process of adaptation, where sequences are captured from foreign nu…

Check out the cool related study by Shally Margolis and Alex Meeske www.sciencedirect.com/science/arti...

@leahmsmith.bsky.social

Type I CRISPR-Cas immunity primes type III spacer acquisition CRISPR-Cas systems are diverse, with microbes harboring multiple classes and subtypes. Type I DNA-targeting and type III RNA-targeting systems often c…

Ever wondered why some bacteria have multiple CRISPR-Cas systems? Our new study led by Leah Smith shows how type I CRISPR systems can promote the acquisition and retention of new spacers into a co-occuring type III system. www.sciencedirect.com/science/arti...

We’re building a team! 🔬I currently have open positions for a lab technician/ manager and a PhD candidate. I’m also always happy to hear from curious, motivated scientists interested in microbial defense, molecular machines, or structural biology.

Please get in touch! 🚀

Research position in Microbial Pharmacology and Population Biology (282139) | UiT The Arctic University of Norway Job title: Research position in Microbial Pharmacology and Population Biology (282139), Employer: UiT The Arctic University of Norway, Deadline: Wednesday, August 27, 2025

Feels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you
www.jobbnorge.no/en/available...

Protein Structure Informed Bacteriophage Genome Annotation with Phold Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents. Here we introduce Phold, an annotation framework utilis...

Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n

www.biorxiv.org/content/10.1...

Can leaf MICROBES help protect MAIRE TAWAKE from MYRTLE RUST? In our next Rangahau Rising kōrero @hanareiaehau.bsky.social shares research into the microbiome of this endangered tree and what it could mean for forest resilience in Aotearoa
Wed 20 Aug | 12–1 PM | Zoom
🔗 Register: tinyurl.com/25x2jwae

Group Leader – Molecular Systems Biology Unit Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...

Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!

Bacterial Schlafens mediate anti-phage defense Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...

First preprint from the Nemudryi Lab! 🍾

In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.

www.biorxiv.org/content/10.1...

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77