Fred Strathmann

Some of the hardest challenges in proteomics and metabolomics appear after measurement. As Gary Patti noted, faster workflows often trade certainty for speed. Adding another separation dimension is helping labs gain confidence without added complexity. #Trailblazers2026

The metallome is one of my favorite omes. Can’t wait until it’s front and center!

“This complexity calls for an additional dimension of separation beyond chromatography.”

Genentech demonstrates HRIM resolving PS diastereomers across therapeutic oligos, turning a trial-and-error challenge into a predictable analytical strategy.

pubs.acs.org/doi/10.1021/...

“What would you tell a girl who thinks science isn’t for her?”

For International Women & Girls in Science Day, we asked the women of MOBILion to share their thoughts.

One message stood out: there’s more than one way to belong in science.

What would you say? 👇

#WomenInSTEM

Using ion mobility has often meant trading breadth for focus.

For Christopher Chouinard, high-resolution ion mobility changed that, enabling wide, untargeted separations that deliver clearer identification in complex, real-world samples.

#Trailblazers2026

Our CTO Daniel DeBord is heading to US HUPO 2026 with 3 presentations you won’t want to miss:

⚡ Lightning Talk + Poster: Waste Not, Want Not (single-cell proteomics)
🧬 Poster: From Blind Spots to Breakthroughs (PTM analysis)

Connect with Daniel or Mick Greer while you’re there.
#Trailblazers2026

MS2 speed limits proteome depth and completeness. When acquisition is slow, many peptides never get fragmented, driving undersampling and missing values. SLIM separates precursors in time to enable >500 Hz MS2 with high ion utilization.
www.biorxiv.org/content/10.1...

Big congratulations to our CEO, Melissa Sherman, Ph.D., on being named a 2026 Women of Precision Medicine Honoree by DeciBio Consulting.

Proud to see her recognized among leaders shaping the future of precision medicine.

www.decibio.com/insights/wom...

MOBILion Systems' CTO Daniel DeBord will be presenting at the Gordon Research Conference:

"Mass Confusion? High Resolution Ion Mobility Brings Clarity to Ion Fragmentation Analysis”

📅 Feb 25 | 🕚 11:50 AM – 12:20 PM

#Trailblazers2026

For years, ion mobility meant tradeoffs: accuracy vs speed.
Tim Causon found @mobilionsystems.bsky.social HRIM delivered stable, reliable data in routine use, repeatable CCS, aligned fragments, and separations that distinguish close compounds without slowing LC.
A clearer standard. #Trailblazers2026

What’s the international equivalent of ASMS?

Progress in pharma doesn’t usually come from a single breakthrough. It happens steadily over time, with each step bringing greater clarity.

In Pharma’s Almanac, @mobilionceo.bsky.social Melissa Sherman reflects on key advances.
🔗 pharmasalmanac.com/articles/looking-back-over-the-last-30-years

For years, lipidomics faced trade-offs: depth or throughput, accuracy or reproducibility.

That constraint no longer holds.

A new study shows HRIM delivers ~0.1% interlaboratory CCS precision while enabling deep triglyceride characterization, turning “or” into “and.” pubs.acs.org/doi/10.1021/...

Trailblazers aren’t defined by titles or timelines. They’re defined by the courage to do things differently, questioning assumptions, pushing limits, and moving forward when others say “this is how it’s always been done.”

This is where it begins.

#Trailblazers2026 #ScientificInnovation

As 2025 wraps, we’re grateful for a year of curiosity, collaboration & breakthroughs with our scientists, partners & customers. We look forward to the new challenges, milestones & discoveries that lie ahead in the new year. Warmest wishes from all of us at MOBILion Systems.

"We've always done it that way" costs drug developers time, money and potentially better therapies for patients. Listen to our podcast feature to hear us explain how traditional LC-MS workflows create blind spots, missing PTMs and slowing drug development: deeptechdigest.com/biotech/base...

Chimeric MS2, <1% ion utilization, 90% signal loss, workarounds dressed up as innovation. All problems that trace back to one thing: the quadrupole. Maybe it's time to stop believing it's all we have. analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.... #IonMobility #itSLIM @asms.org

It’s a great idea - what if IMS was as selective as a quadrupole?

Happy Thanksgiving from all of us at @mobilionsystems.bsky.social. This year we reached new milestones by pushing boundaries with our customers, partners & team. Thank you for being part of our journey. Wishing you a wonderful holiday with your loved ones.

Nikolai Slavov and Daniel DeBord and share how HRIM is transforming proteomics and beyond in The Analytical Scientist. Read how SLIM and other ion mobility platforms are redefining what’s possible: theanalyticalscientist.com/issues/2025/... #Proteomics

Interesting idea, though I’m not sure I see it the same way. On a GC or LC compatible timescale, perhaps, but the technology from MOBILion is just getting started. We’ve shown interesting carbohydrate separation with even commercial systems. Not including ultra high resolving power modes.

I'm developing my belief that physical and temporal separation is reaching its maximum potential for complexity. My research track of dealing with complex carbohydrates is working around separation limitations, starting from data feature engineering.

Still wrestling with sample complexity and poor resolution in your analyses? Our new study shows how ultrahigh resolution ion mobility could streamline biomarker/drug separations. Full paper published in JASMS: pubs.acs.org/doi/10.1021/...

#IonMobility #MassSpec #Bioanalytics #SLIM @asms.org

The 24th HUPO World Congress is next week in Toronto, Canada. Make sure to add our poster session on how ‘PAMAF Analysis Enables 1,000 Hz Speeds with 100% Ion Utilization for Fast and Sensitive Discovery Workflows’ to your agenda. See you on Tuesday Nov 11, at 1:15pm. #PAMAF #Proteomics #HUPO2025

Interesting viewpoint. We’ve shown integration of HRIM with 250 RP and an Exploris 480 which seems like a nice combination on paper - but the Orbi is too slow. Astral would work, and maybe even the MRT? High RP QTOFs appear to be the ideal match. Can’t wait to hear your reply!

Is this a situation where CCS with ion mobility helps as another layer of ID? Asking for a friend.

Profiling Multiple Steroid Subclasses Enabled by Rounded Turn SLIM Ion Mobility Ion mobility-mass spectrometry has shown tremendous potential for improving the analysis of various subclasses of steroids. Its speed and ability to separate isobaric and isomeric species makes it id...

New paper from Clemson University shows how our low mass optimized platform delivers faster, more accurate
steroid analysis for challenging low-mass isomers. Read it in JASMS here: pubs.acs.org/doi/10.1021/...

#MOBIE #IonMobility #Steroidomics #MassSpec

Exciting news! Dr. James Dodds (UNC) will present his year-long work with the #MOBIE system at the upcoming Southeastern and Southwest joint regional meeting of the American Chemical Society. Join his session:
📅Mon, Oct 27 | 🕐1:30 PM | 📍Nautilus A @acs.org

Poisoned? Or just well educated? 😀

I’m not sure if I’ve biased ChatGPT but when I asked it for input it went to HRIM pretty quickly. I think a lot of folks would probably agree!