Fred Strathmann

Pretty impressive results. One has to wonder which, internally, is more advanced and ready to be put on an commercially available instrument.
Thermo's in-development IMS or Mobilion's SLIM? If it's the latter, maybe there will be an acquisition.

Spaces are filling up fast for our ASMS breakfast seminars! On Monday June 2nd, we will be joined by Dr. Sarah Choyke from Eurofins Specialty Services for a presentation on driving Advanced #PFAS analysis. Register here: go.mobilionsystems.com/ASMS2025_Bre... #ASMS2025 #MOBIE

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#Proteomics #PAMAF #MassSpec

Mark Strynar of the EPA highlights the value of non-targeted analysis in environmental monitoring to detect unknown chemicals missed by traditional methods. Technologies like our MOBIE system provide more confidence for identifications.

Learn more: www.sciencedirect.com/science/arti...

Technically, maybe. But doubt you’d get an answer out of the instrument. It’s hard to let go of the freedom of a typical mass spec for a locked down clinical analyzer. This likely only works for those that never did mass spec and won’t know what they’re missing. That makes me question the menu.

It’s an amazing innovation and exciting. I’m not convinced those with mass specs will switch. We’ll see some test volume shift from reference labs to hospital labs. But the math will have to be right and turnaround time reduction won’t justify most of the menu. We need a solution for proteins IMO.

I’ll have Daniel DeBord our CTO reach out to you so you can get more detailed answers. If you send me an email at frederick.strathmann@mobilionsystems.com I’ll forward to him.

I snapped too soon to show the peptide numbers, here they are:

We’ve done both to date. We’re using Spectronaut for processing which uses MS2 by default I believe. Just began working with DIA-NN as well, just for awareness.

Low load is where we shine even more with #PAMAF from @mobilionsystems.bsky.social.

Protein IDs for early #PAMAF performance on an Agilent QTOF (fyi - not our final detector) #USHUPO

My favorite graph so far from @mobilionsystems.bsky.social showing what #PAMAF can do:

No need for leaks, we’re bringing everyone along our journey as we build towards the future. Happy to talk more about where we are today and I’ll send some screen grabs for those not able to be here. #USHUPO

Today is the day at #USHUPO. Get ready to toss your quadrupole and embrace high-resolution ion mobility for proteomics from @mobilionsystems.bsky.social. Maybe we can finally find those missing 1273 proteins. Don’t get me started on PTMs.

I took this slide image that you may find of value. Though embarrassingly not for the science - my niece’s name is Athena.

Isn’t this just meant to keep dissenters busy rather than focused? Seems to be working as much of what I see are jokes and rude remarks. Funny? 100% and great for the comedians in world to spread some joy, keep it up. But where’s the accurate and balanced information? Help me find it, for real.

A great idea if it can help close the divide, not just be a left-skewed rebuttal every day. There is truth on both sides and there are certainly real people on both sides. Different opinions and the freedom to express is what makes us great. Let’s find a balance that makes a positive path forward.

Maybe Google is more about consumerism at this point? Since streaming services and tickets come up and the venue is buried at the bottom. Maybe a shift in what was once perceived as valuable information. The ChatGTP answer has information not asked for either IMO.

I’m not sure I understand your point. Is it the Google does not expand into information not requested automatically? I often find ChatGPT dumps excess data I didn’t ask for originally.

Exciting to see @mobilionsystems.bsky.social on Bluesky. Still posting on the other place but clearly recognizing the trend that is occurring and staying out in front as always!

I do think there’s an affinity technique that could be positioned upfront of mass spec where this added information is not lost. Best of both worlds - simple IDs and concentration of the proteome by affinity and then more targeted deep dives by mass spec to finish out and verify. That excites me.

Definitely a case for follow up with mass spec after affinity - great approach. But what about the proteins that do not change concentration yet PTMs are indicative of the biology of interest? Lost forever in these efforts? How would Olink alert the end user to look deeper? I don’t think it can.

A very interesting comparison and use case for affinity techniques. But with Olink specifically, I wonder about all that biology being missed. Protein IDs and concentration only? Makes the lab medicine part of my brain very sad.

I feel like my dad when he started complaining about paying for cable when commercials first started there.

Not quite 8. Depending on frame length and accumulation time we could get 4 to 5 points in a second if my math is right. Very specific mass being looked at makes DMS suitable assuming the signal loss is not a problem - that was my limitation using DMS previously.

DMS is a start. HRIM would make it so much better. Need something to buy back that specificity lost with that amazing speed.

Forever Chemicals, Endless Testing? Expert Advice to Be Prepared for Per- and Polyfluoroalkyl Substances Podcast Episode · Clinical Chemistry Podcast · 12/04/2024 · 12m

Here is a link to a podcast I was on recently where I discussed a Q&A recently published in ClinChem about #PFAS. Let me know if you’d like a link to the article. podcasts.apple.com/us/podcast/c...

Still fairly new on Bluesky. Forgot what it was like to scroll and actually want to like a post out of enjoyment.

Exactly how we’ve gotten every one of our dogs. Pretty sure my wife is on to me when we just “happen upon” an adoption event.