Caro Goujon

Thank you @harmitmalik.bsky.social! There are still many aspects of the mechanism at play with the enigmatic MX1 protein that we do not yet understand. Further research needed! ☺️

and last but not least @irim-life.bsky.social @cnrs.fr @umontpellier.bsky.social

Special thanks to great collaborators @sarahgalloism.bsky.social @corentinaube.bsky.social Emiliano Ricci, Manu Labaronne, Nadia Naffakh, Bénédicte Delaval, Raph Gaudin @gaudinlab.bsky.social, our funding agencies @erc.europa.eu @frm-officiel.bsky.social,

Highly collaborative work between Joe and many former and current team members @irim-life.bsky.social: Jimmy Cadènes, Francisco Garcia de Gracia, Mary Arnould, Ana Luiza Chaves Valadão, Marine Tauziet, @arebendenne.bsky.social et @oliviermoncorge.bsky.social.

schematic showing MX1 mode of action

transiently associates with them, and induces their retrograde transport via dynein and the microtubule network toward a perinuclear region near the microtubule-organizing center (MTOC), where the vRNPs remain sequestered.

Contrary to previous assumptions, we show in this study that the human restriction factor MX1 most potently inhibits human influenza A viruses during the late stages of replication. MX1 appears to sense trafficking viral ribonucleoproteins (vRNPs) en route to the plasma membrane,

Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...

After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...

The Goujon Lab at the gala diner, Abbaye de Vallemagne

Opening of #NSV2025

The Goujon Team with former member Joe McKellar

NSV2025 beach party venue

The Goujon Team at the beach party, feet in the sea!

Finally taking the time to post about the fantastic conference #NSV2025, which was held at the #Corum, here in #Montpellier, South of France, and co-organized by Paul Duprex, Wendy Barclay, Sean Whelan and @oliviermoncorge.bsky.social! My whole team was there and we had a fantastic time!

Thanks Nate!!!!

Research assistant (postdoc level) in molecular virology, EU-funded project APPEAL (Montpellier, France) The research assistant with a PhD in molecular virology (RA, 'ingénieur de recherche' in French) will work on the Horizon Europe-funded APPEAL project involving 13 partners from 6 countries, including...

New job offer in the team! If you're an experienced virologist (with a PhD), join us to work on Horizon Europe-funded APPEAL project in the vibrant city of Montpellier, South of France! euraxess.ec.europa.eu/jobs/359640

congrats Roy!

Un nourrisson atteint d’une maladie génétique ultra-rare reçoit un traitement personnalisé inédit Un nourrisson atteint d’une maladie génétique aussi rare que sévère a bénéficié aux Etats-Unis d’une technique innovante, appelée édition de base, capable de corriger une seule lettre de son ADN. Cett...

Un nourrisson atteint d’une maladie génétique ultra-rare reçoit un traitement personnalisé inédit
A lire sur 'Réalités Biomédicales'
www.lemonde.fr/realites-bio...

A new article estimates that even a 10% DECLINE in MMR vax coverage in the US could lead to 11 MILLION US measles cases over 25 years.

IF instead MMR coverage INCREASES by 5%, cases would falled to <10K.

Given infectiousness of Measlies, it's VITAL to ⬆️ MMR vax rates.

Measles info below 1/2

Abstract submission and registration deadline for #NSV2025 coming super soon, don't miss it: it will be a fantastic meeting in our lovely city of Montpellier! Please repost ☺️

A second child has died in the Texas measles outbreak Health Secretary Robert F. Kennedy Jr. is expected to attend the child's funeral, which is scheduled for Sunday.

Seems very unecessary. Get vaccinated

www.nbcnews.com/health/healt...

Just submitted my abstract for #NSV2025, which will take place in Montpellier in June - What about you?

#NSV2025 Two weeks left to register! The abstract submission/registration system on the website will CLOSE Friday, April 11, 2025. Visit www.negativestrandvirus.org/home

👇👇👇

Claire Lacouture, jeune chercheuse à @irim-life.bsky.social (équipe dirigée par D Muriaux et C Favard) s'engage pour la recherche sur le VIH avec @sidaction.bsky.social et participe à la campagne de collecte de dons :

www.tf1.fr/tf1/sidactio...

www.france.tv/france-2/sid...

"This week, Elon Musk said 'The fundamental weakness of Western civilization is empathy.' Elon's words reminded me of this: Anthropologist Margaret Meade noted that the first sign of civilization was a healed human femur...."

Le HCERES est-il lui-même évalué ?
Question quasi shadokienne mais qui pourrait conduire à l’économie des 30 millions d’argent public annuel que coûte ce parasite institutionnel.

well after my technical training, I joined one of the best universities in France (ENS Lyon), did a PhD, a postdoc in a fantastic lab in London, and have been a PI for 10 years now… not sure what became of that toxic postdoc though!
don’t let anyone undermine you! #WomenInScience 💪🏻💪🏻

I also have a few examples of my own… as a #FirstGen student, I started with a technical training. during my first intership, a postdoc asked me what I wanted to do afterwards and when I said pursuing my studies and do a PhD, the reply was ‘oh, but you’d need to be clever for that… didn’t you know?´

Don't forget to register and submit your abstract for #NSV2025 in Montpellier! The abstract submission/registration system on the website will CLOSE Friday, April 11, 2025.
Visit www.negativestrandvirus.org/home

I was going to say pretty sure my team members grow them at 37C in regular Top10 bacteria but @mollyohainle.bsky.social was faster 😉 (always worth checking the restriction profile though)

Negative-Strand RNA Virus meeting #NSV2025 registration is now open!
Visit www.negativestrandvirus.org/home

#WomenInScience celebration @irim-life.bsky.social, Day 6: meet Elodie Bishop, PhD student in @caro_goujon's team

Graph showing that prior to 1963 when the measles vaccine was introduced, there were around 300,000-700,000 measles cases per year. Within a few years of the vaccine, the number of cases fell below 20,000/year. There were a blips where cases rose, but shortly after the second vaccine dose was recommended in 1989, annual cases have generally been well below 1,000 cases. In 2000, measles elimination was declared in the US. Now we have sporadic outbreaks that typically spread among unvaccinated people. Chart is from Center for American Progress and is based on CDC data on measles cases.

Vaccines work! As measles cases have recently been reported in Alaska, Georgia, New York, Rhode Island and Texas, it's important to remember that prior to the introduction of the measles vaccine in 1963, measles killed 400-500 people and resulted in ~48,000 hospitalizations per year.

#WomenInScience @irim-life.bsky.social ! Meet my favorite autophagy expert!! 👇