Buszczak Lab

Cara Brand Department of Genetics at Rutgers University

Cara will continue her work on coevolution between DNA satellites and essential host proteins in her new lab in the Dept of Genetics at Rutgers! See: genetics.rutgers.edu/people/facul...

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila.

Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and
@buszczaklab.bsky.social!

www.biorxiv.org/content/10.6...

Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS Recent work suggests that asymmetric segregation of preexisting and newly synthesized canonical histone 3.1 (H3.1), but not variant histone 3.3A (H...

ONLINE NOW: CRI's Ohlstein Lab presents new research that reevaluates whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila, in @pnas.org. Read more ⬇️ www.pnas.org/doi/10.1073/...
#relentlessdiscovery 🧪

Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

Science has already saved countless lives and will save many more if we let it. Hearing firsthand from patients whose lives have been saved by medical research (tinyurl.com/m65339fh) shows how vital this funding is, even for those lucky enough not to have needed it yet.
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A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.