Tyson V. Sharp @tysonsharp - Bluesky Profile

Tyson V. Sharp

@tysonsharp.bsky.social

🔬 Cancer biologist 🧬 Exploring synthetic lethality in lung cancer 💻 CRISPR screens | 🧪 Drug targeting | 🧠 Tumor suppressors 📍Barts Cancer Institute | 📢 Preprints + peer-reviewed science 🚫 LIMD1 loss ≠ untargetable

92 Followers | 5 Following | 1 Posts | Joined: 18.11.2024 | 1.3201

LIMD1 Loss Confers a GPX4-Dependent Cell State in Lung Cancer LIMD1 (LIM domains containing 1) is a bona-fide tumour suppressor gene frequently lost during the early stages of non-small cell lung cancer (NSCLC) development, resulting in a worse outcome for LIMD1...

🧬 New study: LIMD1 loss in lung cancer makes cells GPX4-dependent — a new Achilles' heel we can target!
Our CRISPR screens + validation show that ferroptosis inducers selectively kill LIMD1-deficient cells.
🧪 Read it on bioRxiv: doi.org/10.1101/2025...
#Ferroptosis #LungCancer

08.06.2025 09:10 — 👍 1 🔁 0 💬 0 📌 0

@tysonsharp is following 5 prominent accounts

The Francis Crick Institute
@crick.ac.uk

We're the Crick, a biomedical research lab in London working to figure out how life works. Home to more than 2,000 scientists and a free public exhibition space. https://www.crick.ac.uk/

Cancer Research UK City of London Centre
@cruk-cityoflondon

A world-class hub for research into cancer biotherapeutics. We foster collaboration between scientists at King's College London, University College London, Barts Cancer Institute (QMUL) and The Francis Crick Institute. https://www.colcc.ac.uk/

Nature Reviews Cancer
@natrevcancer.nature.com

Nature Reviews Cancer is a monthly review journal for researchers working on cancer. We, the editors, highlight the most exciting topics in cancer research. https://www.nature.com/nrc/

Barts Cancer Institute (Queen Mary University of London)
@qmbci

Barts Cancer Institute is a leading UK cancer research institute, part of Queen Mary University of London and a partner in the Cancer Research UK City of London Centre. 🧪🧬🔬 https://www.bci.qmul.ac.uk/

Bluesky
@bsky.app

official Bluesky account (check username👆) Bugs, feature requests, feedback: support@bsky.app

Latest posts by tysonsharp.bsky.social on Bluesky

@tysonsharp is following 5 prominent accounts