Virginia Giolito

Tumor acidosis: Fusing mitochondrial dynamics and lipid metabolism Cancer cells experience multiple stresses within tumors, stemming from elevated metabolic activity, including nutrient shortage, waste buildup, hypoxia, and acidosis. According to Groessl et al., acid...

Tumor acidosis: Fusing mitochondrial dynamics and lipid metabolism: Cell Metabolism www.cell.com/cell-metabol...

I was honored to speak at #FIPCongress in 🇩🇰 about my work on CRC during the Pharmaceutical Scientists in Cancer Research session. This milestone allowed me to connect with colleagues and discuss the importance of FIP's support for science and young scientists.

🙏 Thanks to FIP and all participants!

5/5
👏 A big thank you to all colleagues and collaborators who contributed to this journey. And of course funding agencies for their support.

#Metabolism #Acidosis #LipidUptake #CellStress #Cancer #Cardiovascular #AdvancedScience

4/5
🤔 Our findings open new doors to understanding how cells cope with metabolic stress not only in cancer but also in other disease states, including inflammation, acute kidney injury, and ischemia.

3/5
Moreover, we revealed the deep interconnection of lipid metabolic fluxes: blocking one pathway leads to harmful lipid overload within cells, highlighting a specific role for peroxisomes in handling PUFAs under acidosis and uncovering a resulting therapeutic vulnerability.

2/5
🤓 In short, we demonstrated that in cancer cells, endothelial cells, and cardiomyocytes, acidosis enhances fatty acid uptake through a physico-chemical mechanism that bypasses genetic and transporter controls.

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutr...

1/5
Excited to share our latest paper, the result of an incredible collaboration with Sèbastien Ibanez, with whom I share co–first authorship.
This project was led with the support of Pr Olivier Feron and Pr Chantal Dessy. Thank you for your trust!
🔗 doi.org/10.1002/advs...
More in thread👇🏼

Nice to end up the week with an accepted paper 🥳
More info to come 😉

Thanks to the International Society of Cancer Metabolism for giving us the opportunity to show our Network today at #ISCaM2025 and giving opportunities for students and early career researchers 🤩
@virginiagiolito.bsky.social

I am fine, I hope you too! We should catch up soon indeed 😀😘

Looking forward to the EACR Early-Career Researchers' Conference! @helloeacr.bsky.social #ECR

Congrats, Aris 🥳 so happy for you!

Are you interested in #CancerMetabolism? Join us in Brussels from July 2 to 4, 2025, for the 12th annual meeting of #ISCaM! We have a fantastic line-up and many opportunities for early-career scientists!
Submission deadline 📝💻: April 30th, 2025
Early registration deadline: May 18, 2025

Are you interested in #CancerMetabolism? Join us in Brussels from July 2 to 4, 2025, for the 12th annual meeting of #ISCaM! We have a fantastic line-up and many opportunities for early-career scientists!
Submission deadline 📝💻: April 30th, 2025
Early registration deadline: May 18, 2025

When you get the results from some key experiments, and you realise that your hypothesis is spot on! 🎉 Feeling so pumped to dive deeper into this story with even more passion and energy! 🤓👩‍🔬 #ScienceJoy #ExperimentSuccess #teamwork

🎙️ ¿Ya escuchaste el segundo episodio de Ciencia en Voz Alta?
@virginiagiolito.bsky.social nos cuenta qué la motiva a hacer ciencia 🧪 y cómo esa pasión impulsa cada paso en la Maratón de la Ciencia 🏃‍♀️

🔗 Escucha el episodio completo (link bio)
#Podcast #CienciaEnVozAlta #Motivación #PasiónPorLaCiencia

I am thrilled to have received the IREC Institute grant for my research on colorectal cancer organoids. This is a significant milestone for me, marking my first grant as a postdoctoral researcher! I'm pleased that my ideas were well received, and I am excited to dive into this important work. 🔬👩‍🔬

No se pierdan este episodio en el que me invitaron desde @cienciaenvozalta.bsky.social y donde hablamos con @clarissebrunet.bsky.social de muchas cosas interesantes! Espero que les guste y no se olviden de seguir y escuchar el podcast 😉

New research from Olivier Feron’s lab! Special congrats to my partner in crime in science and life, Sebastien Ibanez co-first author of this paper! I am happy to have contributed to this story www.nature.com/articles/s41...
#acidosis #cancermetabolism

📣 The EACR 2025 Congress Call for Abstracts is now online!

Submissions open Monday 02 December: 2025.eacr.org/abstracts

#EACR2025 #CancerResearch

Submit your abstract by 16 December for our upcoming virtual conference 'Drugging and Regulating the MAP Kinase Pathway' with Boehringer Ingelheim!

Don't miss the opportunity to showcase your research: eacr.org/conference/b...

#CancerResearch

Inspired by the other amazing starter packs - here's one for cancer researchers!

I tried to make this broad - from immunology to genomics to cell biology and so much more..

This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺

Hope its useful!

go.bsky.app/FEoaJMc

Great initiative! Thanks Johanna! I would love to join!