Ruizhao WANG

That was so cool!

Humanized Caffeine-Inducible Systems for Controlling Cellular Functions https://www.biorxiv.org/content/10.1101/2025.06.13.659463v1

That was cool👍

Cool, intresting findings, could be invented as tool for transcription control?

Very cool study!

I have a lot of recommendations if you are in China😀

Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases

In new work @arcinstitute.org, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

Congrats! Useful tools!

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - Nature Biotechnology Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - @michellefrei17.bsky.social @jinzhanglab.bsky.social go.nature.com/3GfqrzL

Smart idea! Bring phos-sensor to transcription activation?

Wow, I heard the report before. Congratulations!

Wow, congratulations!

Engineered nucleocytosolic vehicles for loading of programmable editors Engineered nucleocytosolic vehicles for loading of programmable editors (ENVLPE) with enhanced CRISPR ribonucleoprotein (RNP) loading and stabilization enable the efficient delivery of gene-editing ef...

www.cell.com/cell/fulltex...
ENVLPE, our system for VLP-based delivery of gene editors, is now published in @cellcellpress.bsky.social. We showed efficient delivery of base- and prime-editors in primary T cells & in vivo retinal models. All core constructs are available from @addgene.bsky.social.

Great work and very impressive!

Haha

Wow, congratulations!

Congrats!!

LIDAR is out! rdcu.be/efugD We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.

I love this concept!

So cool!

Wow, so cool! Welcome to Westlake talk about the new story again!

Congrats!! I thought you would open your lab one day since the first message with you!!

Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...

I see; thank you for pointing it out. I read this cool paper this morning--using directed evolution on some key mutations to reduce the leakage background activity, and the final construct LATeNT has ∼36% the activity of wild-type TeNT. Very impressive work! Love it.

新年快乐！

Painting by Sir Charles Bell depicting opisthotonos, which can be caused by tetanus (1809)

Tetanus on demand! (not for bioweapons, but for neuroscience research)

Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release.

To harness this toxicity and use it as a beneficial tool for neuroscience,

Wow, cool! Another fantastic neuroscience tool. How to reduce the toxicity of LATeNT in the dark model, and will it cause injury once activated? or in an acceptable range to induce inhibition but not paradeath?

Very cool work! Thermo-controllable protein translocation.

Human-mid protease controls secreted proteins

HaloTag goes so fascinating. Nexe step?