We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...
We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...
Salt supplementation-induced metabolic reprogramming in Streptomyces coelicolor
#mSystems from @nmouncey.bsky.social
journals.asm.org/doi/10.1128/...
“A complete joke”
After the starting gun fires, Australian researchers have to wait 2–3 years before even starting the race.
Really clear article explaining the impossibly long new time-frames for Australian Research Council grants.
By @liammannix.bsky.social
Predicting protein-protein interactions (PPIs) at proteome scale can take months with co-folding models due to the massive all-vs-all comparisons required.
We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/🧵
New post-doctoral research position in my phage-host interactions (Phi) laboratory in @otagomicroimmuno.bsky.social at @universityofotago.bsky.social New Zealand. The project is focused on defences against jumbo phages. Please share and if interested apply using the link in the comments.
04.03.2026 00:20 — 👍 50 🔁 48 💬 5 📌 2
🚨 We’re hiring – MRC-funded Postdoc (3 yrs)
Research Fellow to investigate how mobile genetic elements interact in Staphylococcus aureus and shape gene transfer and pathogenicity.
University of St Andrews
Closes 31 March 2026
www.jobs.ac.uk/job/DQR250/r...
Enquiries: afh22@st-andrews.ac.uk
Radiohead has issued a joint band statement decrying the use of the group’s song “Let Down” in a pro-ICE video, telling the U.S.’s Department of Homeland Security to “go fuck yourselves” for misappropriating the track.
27.02.2026 18:18 — 👍 44 🔁 17 💬 1 📌 3
📢 Funded PhD in molecular microbiology & phage biology
How do bacterial stress responses control prophage activation and horizontal gene transfer?
Join us at St Andrews to dissect Clp protease–mediated regulation in Staphylococcus aureus.
Apply:
www.findaphd.com/phds/project...
Screenshot of LinkedIn post from ARC saying that DP27 EOI outcomes will be released on RMS on the 26th Feb 2026.
The ARC have said (on LinkedIn) they will release outcomes for Discovery Projects Expressions of Interest (2027) tomorrow👇
25.02.2026 03:57 — 👍 36 🔁 21 💬 1 📌 4Role of staphylococcal EzrA as a molecular organizer of cell division https://www.biorxiv.org/content/10.64898/2026.02.20.707072v1
22.02.2026 03:17 — 👍 0 🔁 1 💬 0 📌 0
Something very different and cool for my lab. Sequencing a 4.4mb TB genome using the Artic-style PCR amplicon method with >5128 primers in two reactions 🤯
Enables culture-free WGS for TB!
journals.asm.org/doi/10.1128/...
Fuck sake.
13.02.2026 08:13 — 👍 13 🔁 7 💬 1 📌 0I'd watch a muppet show movie where the muppets infiltrate an academic conference.
07.02.2026 14:45 — 👍 1852 🔁 338 💬 78 📌 155Excited for this new preprint from former postdoc @caitlinkowa.bsky.social identifying unexpected functions for the bacterial stringent response in antimicrobial fatty acid susceptibility in S. aureus #microsky
05.02.2026 21:52 — 👍 14 🔁 7 💬 1 📌 0
What is #Nipah virus and is it a cause for concern?
A 🧵, also at virology blog. 1/
virology.ws/2026/02/05/n...
A cartoon showing the various targets of reconstructed eyesalve against Gram-positive and Gram-negative bacteria. It targets the cell membrane, as well as several intracellular targets including nucleotide biosynthesis. In S. aureus, it also affect quorum sensing.
Remember the medieval remedy we reconstructed years ago? We've now dissected the various ways it attacks and kills bacteria! Preprinted & submitted, led by @tosinorababa.bsky.social & Jess Furner-Pardoe w/ many collaborators #MicroSky #Ancientbiotics www.biorxiv.org/content/10.6...
03.02.2026 09:58 — 👍 34 🔁 13 💬 3 📌 1Always good to start the year with a new preprint. We charted DNA methylation in Salmonella enterica: www.biorxiv.org/content/10.64898/2026.01.27.702048v1.
30.01.2026 11:53 — 👍 5 🔁 3 💬 0 📌 0
Strep/Enterococcal colleagues!
Streptococcal Biology GRC/GRS are open for applications. Acceptances are underway and the meeting is on track to fill up.
If you’re aiming for a short talk (lots of slots), registering early matters for full consideration.
Share widely!
www.grc.org/streptococca...
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
The amount of pain this is going to cause (not just for researchers, but for Research Offices, the ARC, and the ministers themselves) is infinitely greater than the possibility of catching the 0.00001% of grants with potential national security impacts.
13.01.2026 00:03 — 👍 23 🔁 2 💬 0 📌 0
The ARC’s processes are back to being farcical, @jasonclaremp.bsky.social
You advocated for a streamlined, efficient, faster ARC, but all that progress has been undone.
How can they claim to fund “innovation” with more than a year between initial proposal & outcomes? It should be 6 months, not 16!
Discovery Projects are now a complete joke:
EoIs were due 12 Dec last year. Full apps are due 22 April this year. Results won't be out until next year: 15 Jan – 15 Apr 2027.
That’s up to 16 MONTHS!
Black text on white background. Screenshot of ARC’s Network Message regarding delays to grant announcements because of new security arrangements.
⁉️The ARC has delayed outcomes of ALL grants 1–4 months & increased scheduled outcome windows from 2 weeks to 3 months!
This reverses 4 years of progress in providing greater certainty & ability to plan for researchers, their families & unis.
Their excuse? Security checks under new ARC legislation👇
[1/3] Is your favorite bacterial isolate hiding a surprise lytic virus with a VERY different lifestyle? Finally I can proudly say that our paper on persistent phages is out in Nature Microbiology. rdcu.be/eWJEp. Well done @peterdoug.bsky.social
29.12.2025 14:00 — 👍 36 🔁 13 💬 1 📌 4
Interesting new paper on Enterococcus lactis (the species formerly known as Clade B E. faecium)
'The Mannose Phosphotransferase System in Enterococcus lactis Is Essential for Gastrointestinal Colonization'
onlinelibrary.wiley.com/doi/abs/10.1...
We just published in @molsystbiol.org with the Mugler lab (UPitt) on bacterial population dynamics during tumor colonization (mouse model). Our study was guided by a Luria–Delbrück-style idea: infer mechanism from statistics (1/7) 🧪🦠
doi.org/10.1038/s443...
At the end of each year, FDA releases data on antibiotics sold for use in livestock.
It usually changes a few %. This year, it went up 15.8%.
I was shocked & emailed experts/industry groups. Likeliest explanation per a source: industry is not "being good stewards of antibiotics"
Superb work from labs of Elizabeth Campbell + Jeremy Rock @rockefeller.edu Nat Micro
By targeting distinct, functionally vulnerable steps of the transcription cycle, AAP-SO2 overcomes rifampicin resistance, suppresses resistance evolution, and synergistically enhances clearance of drug-tolerant Mtb
Fer’s tour de force in B. anthracis is out! Fer got Tn-seq running, built an ordered knockout library, defined all essential sporulation genes, and found a peptidoglycan deacetylase inhibitor critical for engulfment. Including our first one-by-all Alphafold screen! journals.plos.org/plosbiology/...
13.12.2025 16:53 — 👍 42 🔁 23 💬 0 📌 0
