Ben Davis Group

Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...

www.nature.com/articles/s41...

BGD has been awarded the ICS's Barry Cohen Award for Excellence in Medicinal Chemistry for 2025. www.chemistry.org.il/prizes-page/...

Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygonal web architecture A defining feature of Rift Valley fever virus (RVFV) is the incorporation of the NSs protein into large filamentous assemblies inside infected nuclei [1][1], as judged from fixed specimens. To gain in...

www.biorxiv.org/content/10.1...

Thio-NHS esters are non-innocent protein acylating reagents - Nature Communications N-Hydroxysuccinimide (NHS)-ester derivatives are one of the most widely used acylating agents. In this work, the authors report that ring-opening reaction of the succinimide to afford N-succinamide de...

www.nature.com/articles/s41...

Small-molecule dissolution of stress granules by redox modulation benefits ALS models - Nature Chemical Biology Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

www.nature.com/articles/s41...

Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials - Nature Biotechnology A sunlight-activated chemical spray increases wheat yield in field trials across rainfall conditions.

www.nature.com/articles/s41...

New biostimulant treatment significantly boosts wheat yields, field A novel biostimulant could deliver increased wheat yields of up to 12%, according to researchers from Oxford University, Rothamsted, and the Rosalind Franklin Institute in a long-term study published

www.ox.ac.uk/news/2025-04...

BBC Radio 4 - Farming Today, 30/4/25 Welsh community food strategy, British-grown pulses, biostimulant for wheat New community food strategy for Wales.

www.bbc.co.uk/programmes/m...

Addressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine, Mol Cell Proteomics, 2025, 24(4), 100948, doi.org/10.1016/j.mc...

BGD has been awarded the ACS's Hudson Award for 2025. acscarb.org/awards/hudso...

Isostere 18F-protein post-translational editing enables dynamic tracking of neurodegeneration biomarkers The neurofilament light chain protein (NfL) is a suggested general marker for neuronal loss. Its release from brain parenchyma into cerebral spinal fluid, and presumed detection in blood has seen it e...

Isostere 18F-protein post-translational editing enables dynamic tracking of neurodegeneration biomarkers, bioRxiv 2025.01.26.634877; doi: doi.org/10.1101/2025...

Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress Protein N-glycosylation is a cotranslational modification that takes place in the endoplasmic reticulum (ER). Disruption of this process can result in accumulation of misfolded proteins, known as ER s...

Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress, ACS Cent. Sci., 2025, 11, 107-115, doi.org/10.1021/acsc...

Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide | Open Biology The enterobacterial common antigen (ECA) is conserved in Gram-negative bacteria of the Enterobacterales order although its function is debated. ECA biogenesis depends on the Wzx/Wzy-dependent strategy...

Structure of WzxE the Lipid III Flippase for Enterobacterial Common Antigen Polysaccharide, Open. Biol., 2025, 15, 240310, doi.org/10.1098/rsob...

Start with some...Thoughts for the Future, Nature Chemical Biology, 2025, 21, 6-15; doi.org/10.1038/s415...