Joy Edwards-Hicks

The Hidden Social Lives of Mitochondria When these energy-giving organelles thrive, so do we

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell

great work by Martin Picard

www.scientificamerican.com/article/why-...

Wow, incredibly promising preliminary data on real world use of RSV vaccinations.

Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs A new study shows that people Zepbound lost about 50% more weight than those using Wegovy. It was the first head-to-head trial of the blockbuster weight-loss medications.

Great story from @jonelaleccia.bsky,social

apnews.com/article/zepb...

1/10 Today in @science.org in collaboration with
the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

Some cover art I made for a great paper about the body’s clock and biological aging! #SciArt

✊ Dundee Uni backs down from plans to cut 700 jobs after pressure from unions and the community.

Now they must take compulsory redundancies off the table.

Solidarity works.

Paradoxically, both GIPR agonism and antagonism potentiate weight loss when paired with GLP-1R agonism. Two new studies in @natmetabolism.nature.com decode the different neural mechanisms employed by each strategy.

Check out the #News&Views by @adriaenssenslab.bsky.social here.

Liver Buddies bus

The UK government is promoting a “strategic shift” from “treatment to prevention.”

Healthcare alone cannot restrain demand and prevention requires action on wider determinants of health, say
Vageesh Jain and Thomas Beaney www.bmj.com/content/389/...

So depressing...

The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health-promoting trait (more common in women) linked to strong i....

onlinelibrary.wiley.com/doi/10.1111/...

#Hiring soon for a research assistant with a BSc in #pharmacology, #physiology or #biochemistry.

Looking for someone young and eager to learn, pre-PhD.

Job advert will go live in a few weeks

#newPI #Sheffield #neuroscience #brainbloodflow #CBF #science

Which programming language should I use? A guide for early-career researchers Computer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice.

I write about marimo, and how to choose the right programming language for your research, today in @nature.com www.nature.com/articles/d41...

Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2 https://www.biorxiv.org/content/10.1101/2025.04.19.649664v1

179 experts. 28 countries. 1 message:

Long COVID is real, multi-systemic, and devastating. It affects over 400 million people. And we're not prepared.

New global consensus just dropped.

link.springer.com/content/pdf/10…

🧵

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…

Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell!

We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!

www.sciencedirect.com/science/arti...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

www.nature.com/articles/s42...

Metabolites are not genes. repeat, please!

Cells are swapping their mitochondria. What does this mean for our health? Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

Cells are swapping their mitochondria. What does this mean for our health?

www.nature.com/articles/d41...

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals T cell priming is characterized by an initial activation phase that involves stable interactions with dendritic cells (DCs). How activated T cells receive the paracrine signals required for their diff...

It used to be thought that T-cell priming occurred as single phase. Now we know it takes two.
www.science.org/doi/10.1126/...
@science.org

Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction - Nature Communications MASLD is a growing global health concern. Here, the authors define a senescent hepatocyte gene signature (SHGS), demonstrate its clinical relevance, and identify senolytic therapies that selectively e...

www.nature.com/articles/s41...

First map of human brain mitochondria is ‘groundbreaking’ achievement Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

Scientists have created the first map of mitochondria throughout the entire brain

https://go.nature.com/4c8CLNM

YouTube video by Discovery Dialogues E1 Diabetes Roots

Check out this new podcast by my friend @anideshpande.bsky.social! It aims to delve into the history of groundbreaking discoveries in life, science and medicine. The first episode is a fascinating journey through our understanding of diabetes. I looking forward to future episodes!

Asymmetric phosphoinositide lipid bilayers generated by spontaneous lipid insertion https://www.biorxiv.org/content/10.1101/2025.03.26.645509v1

Axolotls in your timeline!

Neutrophil progenitor cell therapy rescues host defense against Staphylococcus aureus in murine chronic granulomatous disease https://www.biorxiv.org/content/10.1101/2025.03.26.645550v1

Macrophage ferroptosis inhibits Aspergillus conidial killing in lung transplantation https://www.biorxiv.org/content/10.1101/2025.03.13.643092v1

Interesting!

List of Science impacts: one month of Trump 2.0 20 January: Trump’s Day 1 executive orders 21 January: NIH activities suspended 27 January: Freeze on all federal grants 31 January: CDC databases disappear and papers are censored 2 February: NSF unfreezes funds, scrutinizes grants 6 February: Global health efforts imperiled 7 February: Cuts to NIH research overhead funding announced 14 February: Layoffs at US science agencies begin

A truly depressing article in #Nature listing of all the damage done to #science in the US by the Trump administration in just one month

💔 for so many friends and colleagues there

#solidarityforscience 🧪

www.nature.com/articles/d41...

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...

Disrupting cholesterol homeostasis in T cells boosts antitumour responses - Nature Metabolism A new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring cholesterol metabolism, Elovl1-dep...

Elovl1-depleted T cells gain increased fitness and synergize with anti-PD-1 therapy to enhance antitumour responses @nature.com