Penn Neurodegeneration Genomics Center

PNGC says Go Birds!

PennPRS: A Web Tool for Polygenic Risk Scores with Summarized Genetic Data  - PNGC Genome sequencing results can be used to train PRS models but suffer from computation and privacy limitations. A new web portal from Drs. Jin Jin and Bingxin Zhao uses GWAS summary statistics and novel pseudo-training methods to make the latest gener

Genome sequencing results are used to train PRS models but have computation limitations. New portal uses #GWAS summaries and pseudo-training methods to make models more accessible

www.penn-ngc.org/pennprs-a-...

Using lab-grown human mini-brains, scientists find links between head trauma, herpes, and Alzheimer’s Research published Tuesday is the first to connect the dots between a common herpes virus, head injury, and Alzheimer's.

This study from UMASS explores tufts university explores how HSV – 1 might be linked to genetic risk factors for Dementia
#dementia #genesky

Using lab-grown human mini-brains, scientists find links between head trauma, herpes, and Alzheimer’s Research published Tuesday is the first to connect the dots between a common herpes virus, head injury, and Alzheimer's.

This study from UMASS explores tufts university explores how HSV – 1 might be linked to genetic risk factors for Dementia
#dementia #genesky

Researchers Discover 16 New Alzheimer’s Disease Susceptibility Genes | Mass General Brigham The new multi-ancestry, genome-wide study shows promise for improving Alzheimer’s Disease prediction risk and guiding new treatment targets.

Investigators from Mass Gen Brigham have conducted a multi-ancestry, whole genome sequencing association study of Alzheimer’s disease and found evidence for 16 NEW susceptibility genes in underrepresented groups
#genesky

Study by Dr. Plotkin identifies distinct microglial protein signatures in cerebrospinal fluid across different stages of Alzheimer's disease, offering potential biomarkers for early-stage detection and highlighting the dynamic role of microglia

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

It is with mixed emotions that we announce the departure of Dr. Kaylyn Clark from our lab.

Dr. Clark has been an integral part of our lab, contributing immensely to our research in her journey from graduate student to postdoc. Her dedication, knowledge, and positive energy will be sorely missed.

NIAGADS: A Comprehensive National Data Repository for Alzheimer’s Disease and Related Dementia Genetics and Genomics Research NIAGADS is the National Institute on Aging (NIA) designated national data repository for human genetics research on Alzheimer’s Disease and related dementia (ADRD). NIAGADS maintains a high-quality…

(5/5) In October, a preprint was released reintroducing NIAGADS, the National Institute on Aging’s data repository for Alzheimer's Disease research, hosting extensive genetic data and supporting global collaborations to advance research and treatment

www.medrxiv.org/content/10.1...

(4/5) Dr. Kaylyn Clark graduated with a degree in Genomics and Computational Biology from @upenngcb.bsky.social

(3/5) Back in July, our own Dr. Lee , presented his plenary session, "Neuropathology in a Multidisciplinary Age” #AAIC24

(2/5) PNGC researchers presented a bioinformatics strategy for joint-calling 20,504 whole-exome sequencing samples across multiple studies and sequencing centers, successfully accounting for batch effects and generating high-quality variant data

www.nature.com/articles/s41...

(1/5) 2024 was a big year for us! Our scientists produced several preprints, published papers, and attended more than a few conferences

Scroll for some highlights
#genesky #geneticresearch

Find out why Bayesian Tissue Scores are over 100x more efficient in estimating functional annotation effects and context-specific variant fine-mapping compared to existing methods.

See our new preprint

www.biorxiv.org/content/10.1...

#genesky #research

In a recent interview, Pei-Chuan Ho (@pngc.bsky.social/ @pennpathlabmed.bsky.social/ @pennldi.bsky.social) discusses @acadstudy & efforts underway to increase the participation of Asians & Asian Americans in Alzheimer’s Disease research tinyurl.com/4xktvsr4

PhD Opportunities in Dementia Care, I-Care Webinar - DEMENTIA RESEARCHER Discover funded PhD opportunities in dementia care! Join the I-Care DTC webinar on 5 Dec, 12-1pm GMT, to learn more. Online Q&A included. Apply by 22 Jan 2025.

Come and hear more about our 5 PhD opportunities available in our @alzheimerssoc.bsky.social Doctoral Training Centre on Thursday at 12pm www.dementiaresearcher.nihr.ac.uk/event/phd-op... #dementia #phd @i-care-dtc.bsky.social