Keshav Kishor

#glycotime

Hypofucosylation promotes pertussis toxin binding to cell surface glycococonjugates and pertussis toxin-induced intracellular ERK signaling Abstract. Pertussis (whooping cough) is caused by the bacterium Bordetella pertussis. Among the virulence factors produced by B. pertussis, pertussis toxin

Hypofucosylation promotes pertussis toxin binding to cell surface glycococonjugates and pertussis toxin-induced intracellular ERK signaling
#glycotime #Glycobiology

Structural Determinants of Site-Specific Core Fucosylation in Human Transferrin: Insights from Crystallography and Molecular Dynamics Abstract. Core fucosylation of N-glycans, catalyzed by fucosyltransferase 8 (FUT8), plays a crucial role in various biological processes; however, the stru

Structural Determinants of Site-Specific Core Fucosylation in Human Transferrin: Insights from Crystallography and Molecular Dynamics
#glycotime #Glycobiology

#sketchchemistry shenanigans

Orbital parking lots

#chemsky #chemchat

@cenmag.bsky.social

#glycotime

Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies Marglous et al. generated a database of anti-glycan antibody sequences, expressed and characterized a library of 154 antibodies, and generated DNA-barcoded antibodies for single-cell transcriptome and glycome profiling. Glycans associated with cancer stem cells and metastasis were uncovered, demonstrating utility for basic and clinical research.

Online now! Online now! Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies #chembiol

Single-cell glycome and transcriptome profiling enabled by a library of anti-glycan antibodies
www.cell.com/cell-chemica...
@cp-cellchembiol.bsky.social

#glycotime

#internship #co #chemistry #merck #merckchemistry #futuretalentprogram #ftp2026 | Nunzio Sciammetta Merck is hiring 2026 interns & co‑ops across Chemistry disciplines (organic synthesis, enabling technologies, analytical, computational modeling, chemoinformatics, chemical biology, and more) into the Future Talent Program. Below are links to current openings. Please review the job descriptions carefully and apply to the role that best matches your scientific interests and skills. Quick tips: tailor your resume/cover letter to the specific role, highlight relevant techniques/projects, scientific interests, coursework, and hands‑on practical skills, and apply early. Discovery and Process Chemistry Intern: https://lnkd.in/e32PwK7b Discovery and Process Chemistry Co-op: https://lnkd.in/epy5cDSU Chemical Biology Intern: https://lnkd.in/ejE46Qid Protein & Structural Chemistry: https://lnkd.in/eJfaG9Ti Computational Modeling & Informatics: https://lnkd.in/eWsEx2x2 Discovery Sample Management Analytical Chemistry intern: https://lnkd.in/epqm58ea Discovery Sample Management Automation intern: https://lnkd.in/ePwvueYQ DPTM Operations Intern: https://lnkd.in/eVxqtz-2 Chemical Engineering Research & Development Intern: https://lnkd.in/eAae4i2K Chemical Biotechnologies Intern: https://lnkd.in/eUpyuewv Chemical Biotechnologies Co-Op: https://lnkd.in/e4JgtGC2 Data Rich Experimentation Intern: https://lnkd.in/epwNDnG8 Analytical Research & Development Intern: https://lnkd.in/e3rhrNVM Analytical Research & Development Co-Op: https://lnkd.in/e49Gupg8 #internship #co‑op #chemistry #Merck #MerckChemistry #FutureTalentProgram #FTP2026

Undergrad and grad #chemistry students, Merck now has applications open for 2026 internships and co-ops in their Future Talent Program!

Includes discovery, process, chembio,
and computational roles.

One of the directors compiled a list here: www.linkedin.com/pos...

#chemsky

Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration

Just 2 weeks away!! Oct 15 at 12 Noon ET. Join us for the next ACS-DOC @organicdivision.org Virtual Symposium featuring Prof. Marvin Parasram (NYU) and Prof. Brian Stoltz (CalTech)
Free to watch/ no registration - just tune in on YouTube or Zoom with the links in the post below
#ChemSky

Enzyme-Activated Sugar-Coated Bifunctional Degraders Targeted protein degradation with compounds like proteolysis targeting chimeras (PROTACs) directs disease-associated proteins to the E3 ligase ubiquitin-proteasome system for removal. However, commonl...

Enzyme-Activated Sugar-Coated Bifunctional Degraders

FDA approves imlunestrant On September 25, 2025, the Food and Drug Administration approved imlunestrant (Inluriyo, Eli Lilly and Company).

The @US_FDA approved imlunestrant, a selective estrogen receptor degrader or SERD, for adults with ER-positive, HER2-negative, advanced breast cancer with ESR1 mutations that has progressed following treatment with endocrine therapy: buff.ly/fUrc6Vw

opsonization Biological Process Definition (GO:0008228 GONUTS page) The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody.

This definition sounds unnecessarily complicated for something that essentially means "adding seasoning to a pathogen before eating it"

Good ideas come from having lots of experience. And experience comes from having lots of bad ideas.

Linker Methylation as a Strategy to Enhance PROTAC Oral Bioavailability: Insights from Molecular Properties and Conformational Analysis In this study, we profiled 11 structurally related von Hippel–Lindau (VHL)-based proteolysis-targeting chimeras (PROTACs), evaluating in vivo pharmacokinetics in mice (oral bioavailability and clearan...

Linker Methylation as a Strategy to Enhance PROTAC Oral Bioavailability: Insights from Molecular Properties and Conformational Analysis

Open access 🔓

Why would anyone want to be a scientist? There are the pleasures of:
1. Having the initial idea or insight,
2. Watching the idea develop into new experiments or a new model, and
3. Telling others.
Martin A. Schwartz
Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...

Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins. Known cere...

Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition

it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond

“I trust it as far as I can throw it” is basically mass spec

Determining how you feel about things by throwing them real hard

GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy

www.biorxiv.org/content/10.1...

#Glycotime

Picture of a smiling person holding up a copy of a book.

First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.

This book is the guide I wish I’d had then, with the goal of helping others now.
 
jenheemstra.com/book

Cyclopropanation with Non-Stabilized Carbenes via Ketyl Radicals A radical mechanism enables simple and robust access to nonstabilized, alkyl iron carbenes for novel (2 + 1) cycloadditions. This Fe-catalyzed strategy employs simple, aliphatic aldehydes as carbene p...

Having a 1on1 with my supervisor at work and out of the coffee kiosk comes @nagiblab.bsky.social - definitely turned into a great day - had no idea we had a visit on - topped it off with a fantastic chem chat - Thanks Dave! Here’s a cool Nagib lab paper for sharing #ChemSky

The moving target A past experience with target selection reminded me of the uncertainty and messiness of drug discovery.

A past experience with target selection reminded me of the uncertainty and messiness of drug discovery.

medchemash.substack.com/p/the-moving...

“I’m Rapping my PhD” Which conference does that?!?! Vaibhav Mahajan. Out of this world
#theconferencetoendallconferences #TCTeAC

jacs-covers-25

On the cover of this week's #JACS: "Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols"

Read it here 🔗 buff.ly/FJkPjYc
#ChemSky

Glycoproteomic and Single-Protein Glycomic Analyses Reveal Zwitterionic N-Glycans on Natural and Recombinant Proteins Derived From Insect Cells In BriefInsect cell lines are frequently used for expression of recombinant glycoproteins, including vaccines. Using two independent approaches, we show that the endogenous N-glycomes of High Five and...

Typeset version of our latest #glycotime paper now online!
Glycoproteomic and Single-Protein Glycomic Analyses Reveal Zwitterionic N-Glycans on Natural and Recombinant Proteins Derived From Insect Cells - Molecular & Cellular Proteomics
www.mcponline.org/article/S153...

She grabs the pipette thinking "maybe I should publish this SAR" but then remembers Wuxi just delivered 200 compounds that look like they were made by blindfolded undergrads and the biology team needs them screened by tomorrow and Legal still hasn't