Apoorva Baluapuri

A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym

Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.

Excited to see this work published online at @cp-cell.bsky.social today!

www.cell.com/cell/fulltex...

Amazing !!! Congrats on the great work - looking forward to celebrating it this Friday :)

PhD position in Gene Regulation Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!

The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.

Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions Abstract. The dual interaction of many transcription factors (TFs) with both DNA and RNA is an underexplored issue that could fundamentally reshape our und

🎉 Thrilled to share our new paper in @narjournal.bsky.social!
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

Much appreciate the spotlight on our (‪@adelmanlab.bsky.social‬) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology

Do you or someone you know have an exciting new chromatin/transcription story that you'll be ready to talk about in the Fall?

Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬

Exciting new work from Apoorva Baluapuri of the Adelman lab! @baluapuri.bsky.social
@adelmanlab.bsky.social
www.sciencedirect.com/science/arti...

Thrilled to see my work with @adelmanlab.bsky.social on INT/dsRNA highlighted by @willgarland.bsky.social and @heick.bsky.social ! Thanks for beautifully capturing how nuclear RNA guardians prevent cellular chaos. The ripple effects of transcriptional dysregulation are indeed profound! #RNABiology

Join us next Wed, for three amazing ECR researchers_ @fueyoraquel.bsky.social, @kaiamattioli.bsky.social and Laura talk about their work in #FragileNucleosome seminar series!
In case you haven't joined any of the previous 2025 sessions, here is registration link:
us06web.zoom.us/webinar/regi...

Why are there intronic reads in your bulk RNA-seq data?
You're not alone—it's common, and the reasons are more layered than you think.
Let’s break it down. 🧵

Sometimes when I am having a bad day I remember that after my TED talk in 2016 this woman mobbed me afterwards and threw herself on me with the hugest hug saying "Oh my god you were incredible and inspirational I want to BE you"

It was Cher

Was great presenting at @fnucleosome.bsky.social - amazing feedback and participation from the audience. Thanks once again to the organizers:) here’s the link press release for the story for those who missed it : hms.harvard.edu/news/what-ha...

What Happens When a Gene Quality-Control Mechanism Fails? Study solves riddle of how mutations in Integrator complex relate to neurodegeneration, cancer

Read all about Apoorva Baluapuri’s new work on Integrator (INT) in HMS News! @baluapuri.bsky.social @adelmanlab.bsky.social
tinyurl.com/y2fx22c2

You can read our full Review @science.org here 👉👉https://www.science.org/doi/10.1126/science.adp2959

Looking forward to share my postdoc work done with @adelmanlab.bsky.social, and to revisit @fnucleosome.bsky.social as a presenter once more after 3 years !!! Super excited….

Thanks @mpi-ie.bsky.social for the having me over last week and for the great conversations I had at your nice institute cradled in the beautiful Schwarzwald !!

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Another McGill Assistant Professor job at the Lady Davis Institute (where I am)! This is for an immunology (host-virus interactions) position! Come by my colleague! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

🧵 Want to automate bioinformatics tasks?

Start by mastering one of the most powerful tools:

the for loop in bash.

I know I posted about GNU parallel :)

but even "for loops" have a lot to learn

Let’s go.

Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle Control over protein phosphorylation timing is crucial for faithful cell cycle progression. Takacs et al. revisit existing qualitative and quantitative models for cyclin-dependent kinase (Cdk) control of the cell cycle. They provide evidence of a third mechanism in which the substrates themselves contribute to controlling their phosphorylation timing.

Evidence of substrate control of Cdk phosphorylation during the budding yeast cell cycle

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

Hi Erik - could you please add @hms-bcmp.bsky.social @adelmanlab.bsky.social and me @baluapuri.bsky.social to the feed ? Many thanks :)

Kelly Nguyen with her research group

Excellent opportunity available for a motivated #postdoc to join @kellythd-nguyen.bsky.social’s group investigating the roles of histones in regulating telomerase using a multi-disciplinary approach.
More details: www.nature.com/naturecareer...
Apply by 04 MAY
#PostdocJobs #ScienceJobs

Integrator loss leads to dsRNA formation that triggers the integrated stress response Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.

Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response

Thanks Claudia !!

Thanks a lot Ben - following your advice always helped :)

This is also a great time to welcome @adelmanlab.bsky.social to BlueSky !!

Thanks to labs of Eric Wagner, Vik khurana and Ashleigh Schaffer for the awesome collaboration that made this work possible! #RNA #StressResponse #RNA #GeneReg #stemcells #Genomics #RNAsky #GeneRegulation #TEsky #AcademicSky
Check out the paper here: authors.elsevier.com/c/1kwzmL7PXu...