Carbohydrates and Synthesis Research University of Galway

Today in Chemistry History graphic on Sir Norman Haworth, 19 March 1883-19 March 1950. Haworth discovered the molecular structure of vitamin C, and also created its first artificial synthesis. He also deduced the structures of a number of different sugars. Haworth projections are used to depict the cyclic forms of sugars. They are useful because they clearly show which groups are above and below the ring.

Sir Norman Haworth, who won a Nobel Prize for his work on structures of carbohydrates and vitamin C, was born #OTD in 1883 (and died on the same date in 1950): wp.me/s4aPLT-haworth

#ChemSky 🧪

New Synthetic Antibiotics

@dereklowe.bsky.social: "Serendipity is no disgrace! But failing to take advantage of it certainly is!"

Cool new potential antibiotics being discovered: www.science.org/content/blog...

#chemsky 🧪⚗️

Who funds biomedical research? @nature.com
www.nature.com/articles/d41...

“NIH has also requested lists of projects involving…mRNA vaccines, which some vaccine skeptics think are unsafe because they believe, without evidence, that the vaccines could modify DNA or cause various health issues.”

this may derail one of the biggest advances in oncology — cancer vaccines

📢 The thematic issue “Chemical #glycobiology” is complete! DL the issue PDF incl. the editorial by Elisa Fadda @elisafadda.bsky.social, Rachel Hevey @rachelhevey.bsky.social, Benjamin Schumann @drglycoben.bsky.social & Ulrika Westerlind:
➡️ https://www.beilstein-journals.org/bjoc/series/127?B=y
#BJOC

Your Temperamental Diva Reactions

16 year old In the Pipeline comment threads are still good: www.science.org/content/blog... #chemsky 🧪⚗️

Universal Reagent for Mild and Stereospecific Nucleophilic Substitution of Alcohols with Amines A user-friendly, shelf-stable protonated betaine reagent (BEHT triflate), derived from Mitsunobu reagents, has been developed to enable the direct displacement of alcohols using primary and secondary...

Universal Reagent for Mild and Stereospecific Nucleophilic Substitution of Alcohols with Amines - Bechara - Angewandte Chemie International Edition - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1002/...

We will benefit from funding from @researchireland.bsky.social to try to make progress in the glycoscience field. Thanks to Prof Helen Blanchard for cooperation. see for more information at the link. www.universityofgalway.ie/about-us/new...

One of the giants of Organic Chemistry. RIP Prof. Smith

PhD position to develop synthetic carbohydrate materials

#PhDposition available in my group at the @mpici.bsky.social!
Join us to develop new #carbohydratematerials

#chemistryjobs #researchjobs #glycotime

jobs.mpikg.mpg.de/jobposting/a...

High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy Pseudomonas aeruginosa is a critical priority pathogen and causes life-threatening acute and biofilm-associated chronic infections. The choice of suitable treatment for complicated infections requires...

I am very proud to share a long story on lectins and biofilm imaging just published in JACS Au by Eva and Lisa in cooperation with many colleagues such as @anneimb.bsky.social 😍 #glycotime #chembio #AMR please have a look here: pubs.acs.org/doi/10.1021/...

Hardiman PhD Scholarships at University of Galway:

Happy to discuss proposals and assist with applications for doctoral research in the following areas:

Constitutional Law, European Human Rights Law and Public Interest Law broadly.

Details here:

www.universityofgalway.ie/hardiman-sch...

The Azide‐Wittig Reaction More than 100 years after Staudinger's seminal reports on the reaction of iminophosphoranes with aldehydes, an alternative path, the so-called “Azide-Wittig Reaction” has been uncovered. We describe ...

The Azide-Wittig Reaction. onlinelibrary.wiley.com/doi/10.1002/...

Use a gif to show where you’re from

Do chemists die young? Death notices for chemists suggest perhaps not, despite the hazards found in many labs

It is reasonable to assume that chemistry is among the riskiest professions from a long-term health perspective. But, surprisingly, RSC chemists live longer than the UK population by about five years.
www.chemistryworld.com/opinion/do-c...

Potential Safety Hazards Associated with Using N,N-Dimethylformamide in Chemical Reactions N,N-Dimethylformamide (DMF) is frequently used as a solvent because of its unique physical properties that allow it to solubilize both organic and inorganic substances. It has also found broad applications as a catalyst for a variety of chemical transformations and as a donor for many functional groups in synthetic organic chemistry. However, DMF is incompatible with a wide variety of substances and has resulted in many incidents over the years. Analysis of literature information indicates that those incompatible substances can be categorized as acids, bases, halogenated reagents, oxidants, and reductants. This comprehensive review of the potential hazards of using DMF in chemical reactions will serve as an educational resource to promote awareness of such safety hazards in the broader chemistry community and encourage scientists to develop appropriate control strategies to mitigate the potential safety risks associated with the use of DMF in chemical reactions.

Having a reaction safety discussion today at work and sharing some key info about NaH/DMF - this paper is very informative #ChemSky #ChemLabSafety #NoNaHwithDMF

Is basic science undervalued? David Glanzman (UCLA) talks about the decline of 'middle class' labs and that "there is no empirical evidence that the translational approach accomplishes this [cures] any better than the traditional one. Claims to the contrary at this point are mere propaganda."

Small lectin ligands as a basis for applications in glycoscience and glycomedicine Glycan recognition by lectins mediates important biological events. This Tutorial Review aims to introduce lectin–ligand interactions and show how these molecular recognition events inspire innovation...

For something about the area we work in you can check this out.

pubs.rsc.org/en/content/a...

Professor Emerita Dervilla Donnelly: 1930 - 2024

Detailed obituary for Professor Emerita Dervilla Donnelly, a remarkable scientist and public servant. RIP. www.ucd.ie/newsandopini...