Jimmy Ruffian

Anyone who glazes Ai shit at all is a fucking loser, idc. Loser shit.

CLICKHOLE LIFESTYLE Groundbreaking Discovery: Paleontologists Have Agreed To Start Saying That Stegosauruses Had Beautiful Singing Voices Because It's A Nice Thought And It's Not Like They're Hurting Anyone OCTOBER 16, 2017

this is where i'm at mentally these days

"PhD-level experts in your back pocket" is a completely nonsensical description of AI but a pretty good description of social media if you follow the right people

Oh wow you have no idea what you're talking about. Cool.

His commitment to being the most loathsome dork sure is something.

A Google alert announces Chappell Roan concert tickets, but the image is of Weird Al

You sure about this, Google?

Whatever you say, champ.

Yeah, sure, why not respond with aimless gibberish.

Lmfao. People can just log on and say any stupid fucking thing.

Gee, I wonder why quotes and replies are turned off here, you fucking coward

You just gotta LOVE MAD MAGAZINE!!!

To say*

Thanks autocorrect.

People think it's righteous to dau they're gonna *not* vote for someone or something. Quite frankly, I don't think anyone should give a fuck about what you're NOT going to do; but you say it because what you're going to DO is NOTHING.

Voting discourse online is so beyond poisoned and stupid.

People think voting for one candidate over another is cosigning and endorsing everything they ever say and do and that has not ever, EVER been the case with ANY form of vote. You are a propagandized fool and don't realize it.

He's not even good, wtf are you talking about? He's like a textbook definition of spineless milquetoast.

Wait, you think THIS GUY is "perfect"? Lol. Lmao. Jesus Christ.

Linked In post from Mike Matsel, Principle Development Lead, XBox Graphics: "The XBox Graphics team is hiring folks with experience with device drivers, GPU performance, or related validation or engineering system experience. If the positions are closed and you want to apply, please message me!" And below it is an "AI" slop that reads in white on green "XBOX GRAPHICS IS HIRING" and an image of a woman in a green sweater wearing earpods typing on a computer, except the "AI" has put the screen on the back of the monitor.

The fucking head of fucking XBox Graphics used a fucking "AI" slop image to hire new engineers but couldn't tell that the fucking screen on the fucking monitor is facing backwards.

The fact that CBC was too cowardly to film this is indicative of a much bigger problem in media.

When layoffs come, they tend to target journalists who are "problems" for management, who question authority.

This is what you lose when you only keep the journalists who are deferential to authority:

Didn't know he was such a douche.

He decided that many, many years ago.

My podcast is btyb me and my wife having an engaging activity together and the enjoyment of the 8-12 people that watch. I have never made a dime from it.

I think people responsible for this deserve to rot in solitary for the rest of their lives, and it's the everyday citizen that needs to make that happen.

Starting to look like a Nascar driver's jacket

No it fucking doesn't you lazy-brained ignoramus.

Pete Buttigieg being LGB drop the T was on literally everybody's bingo cards

The key, they found, was to use a vaccine that hid a portion of a key protein complex that pokes out of HIV's surface, concealing a region that usually distracts the immune system from mounting a protective response. EDITOR'S NOTE Vaccines for human immunodeficiency virus (HIV) usually target the envelope (Env) trimer that is present on the surface of virions. However, protein-based vaccines require the Env trimer to be soluble; this creates a site at the base of the Env for antibodies to bind that is unable to confer protection against infection. In two papers, Ramezani-Rad et al. and Parks et al. take advantage of mRNA vaccines to circumvent this problem. mRNAs are translated into proteins within the vaccine recipient's cells, enabling the authors to produce membrane-bound versions of the Env trimer. Ramezani-Rad et al. demonstrated that this approach elicited antibodies that bound to the intended, nonbase regions of the Env in preclinical models, supporting progression of this vaccine to clinical trials. Parks et al. report results of a phase 1 clinical trial, showing that vaccination of humans with a membrane-bound Env trimer elicits productive antibody responses, consistent with the preclinical studies. This pair of papers highlights the advantages of mRNA vaccines, especially for HIV vaccine design.

ABSTRACT (PRECLINICAL STUDY) A protective vaccine against human immunodeficiency virus (HIV) will likely need to induce broadly neutralizing antibodies (bAbs) that engage relatively conserved epitopes on the HIV envelope glycoprotein (Env) trimer. Nearly all vaccine strategies to induce bAbs require the use of complex immunization regimens involving a series of different immunogens, most of which are Env trimers. Producing protein-based clinical material to evaluate such relatively complex regimens in humans presents major challenges in cost and time. Furthermore, immunization with HIV trimers as soluble proteins induces strong nonneutralizing responses to the trimer base, which is normally occluded on the virion. These base responses could potentially detract from the elicitation of nAbs and the eventual induction of bAbs. mRNA vaccine platforms offer potential advantages over protein delivery for HIV vaccine development, including increased production speed, reduced cost, and the ability to deliver membrane-bound trimers that might facilitate improved immuno-focusing to nonbase epitopes. We report the design of mRNA-delivered soluble and membrane-bound forms of a stabilized native-like Env trimer (BG505 MD39.3); initial immunogenicity evaluation in rabbits that triggered clinical evaluation; and more comprehensive evaluation of B cell, T cell, and antibody responses in nonhuman primates. mRNA-encoded membrane-bound Env immunization elicited reduced off-target base-directed Env responses and stronger nAb responses compared with mRNA-encoded soluble Env. Overall, mRNA delivery of membrane-bound Env appears promising for enhancing B cell responses to subdominant epitopes and facilitating rapid translation to clinical testing, which should assist HIV vaccine development.

ABSTRACT (HUMAN STUDY) mRNA technology might accelerate development of an urgently needed preventive human immunodeficiency virus (HIV) vaccine. We evaluated the safety and immunogenicity of three mRNA-encoded envelope trimers, including two doses of soluble and membrane-anchored forms, in a randomized, open-label, phase 1 clinical trial. Vaccines were generally well tolerated, although 6.5% (7 of 108) of participants developed urticaria, a higher proportion than seen with other mRNA vaccines. mRNA-encoded trimers induced strong envelope-specific B and T cell responses. Immunization with membrane-anchored trimers, intended to obscure epitopes at the trimer base targeted by nonneutralizing antibodies, reduced the frequency of base-binding serum antibodies in comparison with soluble trimers. Three immunizations elicited autologous tier 2 serum neutralizing antibodies in 80% of vaccinees receiving the membrane-anchored trimers, in contrast to only 4% receiving the soluble trimer. Thus, with demonstration of more favorable safety, mRNA-encoded membrane-anchored HIV envelope trimers represent a promising platform for HIV vaccine clinical development.

The studies have been published in Science Translational Medicine. YES, they are PEER-REVIEWED.
• www.science.org/doi/10.1126/...
• www.science.org/doi/10.1126/...

I fear there is not a single "leader" or "representative" of any kind that has a spine, or so extremely few that there might as well not be any. Cowards and wimps, the whole lot of em.

Americans know they can't tweet a revolution, right?

Fucking hell, eh?

It is too late. I have depicted you as the low-energy soybrain chatGTP user while I am the Chad non-chatGTP user functioning brain.