Quinn Sievers

Proteome-wide in silico screening for human protein-protein interactions Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

She’s so talented!!

Epic #Boston

Are you a postdoc in NYC? Come hang out with us at Postdoc Night Science! We are hosting the event at Columbia on Dec 3 at 5PM. Meet other NYC postdocs as well as @itaiyanai.bsky.social & @stearnslab.bsky.social to talk science & creativity! 🧬🧪

Make sure to use the QR code on the poster to sign up!

@onthemedia.bsky.social

When I was interviewing for grad school (2011), the “missing heritability question” was THE burning question in genomics 1/

A venn diagram comparing Libraries and Pooled Libraries. The Libraries circle reads "made of paper" and shows an illustration of books. The Pooled Libraries circle reads "made of DNA (and sometimes lentivirus)" and shows an illustration of plasmids. In the overlap of the two circles, three entries read: "incredible community driven resource; source of new discoveries; barcodes."

Who doesn't love a library? A pooled library, that is! Grab a hot drink and your reading glasses and enjoy browsing the libraries Addgene has to offer:
https://twp.ai/4it3AO

Harvard To Admit 50% Fewer Ph.D. Students in Science, Walking Back Deeper Cuts | News | The Harvard Crimson The Faculty of Arts and Sciences announced Wednesday that it would reduce the number of Ph.D. admissions slots for the Science division by 50 percent for the current admissions cycle, walking back…

The Faculty of Arts and Sciences announced that it would reduce the number of Ph.D. admissions slots for the Science division by 50 percent this year, walking back plans for even steeper cuts.

William Mao and Veronica Paulus report.

www.thecrimson.com/article/2025...

Congratulations to Dr. Lorenzo Falchi of @mskcancercenter.bsky.social on the FDA approval of epcoritamab-bysp with lenalidomide and rituximab for adults with relapsed or refractory follicular #lymphoma! A huge win for those with the condition. Dr. Falchi will present phase 3 trial data at #ASH25.

#chempro

Probing the proteome - Nature Biotechnology Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?

I envy the glycoscience community for their #glycotime hashtag. A great way to make posts visible. Anyone in #ChemicalProteomics that has a good idea, which hashtag we might use to make all of our work more visible and findable?
#ChemSky #ChemBio #DrugDiscovery #ABPP
www.nature.com/articles/s41...

Ten days left to apply to be a @crick.ac.uk Early Career Group Leader

Closing date 27th November

www.crick.ac.uk/careers-stud...

An 89-year-old woman with severe tricuspid regurgitation presented with fever and cough after a recent diagnosis of influenza. Prominent forehead venous pulsations were noted on examination. Read the full case details: nej.md/3LtKUn3

#MedSky #CardioSky

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells Immunomodulatory imide drugs (IMiDs), including thalidomide, lenalidomide, and pomalidomide, can be used to induce degradation of a protein of interest that is fused to a short degron motif, which oft...

Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells

Are there also folks looking for unmotivated, unenthusiastic postdocs or graduate students? Judging from how often I see these words in ads or postings, there must be some ads I am missing...

:)

The Matthew Effect is alive and well in academia - always makes me wary of programs aimed at identifying rising stars in an already highly talented pool...

elifesciences.org/reviewed-pre...

This is so interesting, thank you for sharing!

Opinion | Cancer Patients Like Me Are Casualties of MAHA’s Hypocrisy

www.nytimes.com/2025/11/11/o...

In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it.

aacrjournals.org/cancerdiscov...

Fred Hutch's Immunotherapy Integrated Research Center is recruiting an Open Rank Faculty position to lead a laboratory-based program focused on tumor immunology and cancer immunotherapy with a strong vision/path toward clinical translation.

Learn more: https://apply.interfolio.com/176403

New Pill From Merck Could Slash Cholesterol Levels, Trials Show

www.nytimes.com/2025/11/08/h...

FDA reverses decades-old warning on hormone therapy products for menopause The FDA is reversing a 2003 decision that put a stringent warning on hormone therapy products for menopausal women, saying that the treatments offer heart, brain, and bone health benefits.

The FDA is reversing a 2003 decision that put a stringent warning on hormone therapy products for menopausal women, saying that the treatments offer heart, brain, and bone health benefits. www.statnews.com/2025/11/10/f...

Supreme Court Denies Request to Revisit Same-Sex Marriage Decision

!!!

www.nytimes.com/2025/11/10/u...

Congrats Caroline!!!

Ben Davis, MD, director of the Swedish First Hill Family Medicine Residency program in Seattle, discusses the biggest shift he has seen among trainees in the past decade in terms of the career paths they are choosing.

#MedSky #MedEd

biology is so cool because like every week someone is like "Dr. Smith is coming to campus! She is the world expert in blargyblarg!"

And i'm like A) never heard of blargyblarg, B) look it up, it's super important and interesting

Arena BioWorks, an ambitious biomedical institute backed by billionaires, abruptly shuts down Exclusive: Arena Bioworks, the buzzy research institute that launched with $500 million to support a decade of scientific R&D, is abruptly shutting down, STAT has learned.

OMG.

Arena BioWorks, an ambitious biomedical institute backed by billionaires, abruptly shuts down www.statnews.com/2025/11/04/a... via @statnews.com

Finally out - our real world study of 740 patients with large B-cell lymphoma receiving polatuzumab vedotin shows higher response rates and PFS for patients with non-GCB LBCL than those with GCB disease, by Hans algorithm.

Thanks David Russler-Germain + collabs

aacrjournals.org/clincancerre...

Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs - Nature Chemical Biology Exploiting the high abundance of mutant p53 protein, a small molecule was developed that specifically binds to p53-Y220C mutants and delivers a mitosis blocker, killing TP53-mutant cancer cells while ...

www.nature.com/articles/s41...

A previously healthy man presented with a 10-day history of blood dripping from one nostril. Twenty days earlier, he had washed his face with mountain spring water. A leech was found on nasal endoscopy (shown in a video). Read the full case details: nej.md/3J6IZUD

#MedSky #Otolaryngology