Quinn Sievers's Avatar

Quinn Sievers

@quinnsievers.bsky.social

Instructor in Lymphoma at Memorial Sloan Kettering and postdoc in the Abdel-Wahab and Vinogradova labs | Big problems, small molecules πŸ³οΈβ€πŸŒˆ

189 Followers  |  154 Following  |  289 Posts  |  Joined: 17.11.2024
Posts Following

Posts by Quinn Sievers (@quinnsievers.bsky.social)

Preview
Degrons and degradation signals beyond short linear motifs - Nature Chemical Biology Degrons are degradation signals in target proteins to direct recognition and degradation by the ubiquitin–proteasome system. Wang et al. introduce degrons of different types, with an emphasis on high-...

www.nature.com/articles/s41...

02.03.2026 10:58 β€” πŸ‘ 10    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Reposting for our team riding in @cycleforsurvival.bsky.social
this Friday. Still time to donate using the link below! Every dollar goes to support patient-facing rare cancer research! Donate here: shorturl.at/U92Sc

02.03.2026 15:43 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Preview
Opinion | The glamour of the front line (Published 2006)

"There is a dirty little secret in journalism: War reporting is the fastest way to get ahead."

My 2006 Op-ed on why war (tragically) remains irresistible to news junkies and journalists: "The Glamour of the Front Line."

www.nytimes.com/2006/02/06/o...

01.03.2026 21:29 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
A line graph showing NSF grant awards made through 2/27/26 for fiscal year 2026 compared with grant awards for fiscal years 2021-2025.

A line graph showing NSF grant awards made through 2/27/26 for fiscal year 2026 compared with grant awards for fiscal years 2021-2025.

NSF Update (Awards through 2/27/26)

Directorates to follow

1/10

01.03.2026 14:48 β€” πŸ‘ 652    πŸ” 436    πŸ’¬ 28    πŸ“Œ 116

β€œThe pattern is clear: When legislation fails, proceed administratively. Close offices through personnel actions. Eliminate review structures through internal reorganization. Redirect missions through policy directives.”

28.02.2026 17:56 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

β€œWeeks after Congress rejected the Trump administration’s proposed cuts to NIH and passed a full-year budget on February 3, 2026, the White House Office of Management and Budget (OMB) has refused to authorize release of the funds.”

28.02.2026 17:55 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I learned a lot reading this. Two important quotes:

28.02.2026 17:54 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
I’m So Used to Gay Tragedies That I Almost Missed Romance

Whew, Wesley Morris on Heated Rivalry is worth your time.

27.02.2026 16:12 β€” πŸ‘ 25    πŸ” 4    πŸ’¬ 2    πŸ“Œ 1
Post image

This week's cover @thelancet.com

26.02.2026 23:48 β€” πŸ‘ 3106    πŸ” 1454    πŸ’¬ 44    πŸ“Œ 80
Post image

What about feedback/comments? Authors clearly want and are getting feedback on articles, but it’s mostly private, via email. Cultural change is needed for this to move to the public comment section, and it will always be distributed (social media, etc.) 4/n

26.02.2026 16:09 β€” πŸ‘ 18    πŸ” 8    πŸ’¬ 2    πŸ“Œ 0

New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version!
It has new data about our progress and highlights from a massive user survey. 1/n
www.biorxiv.org/content/10.1...

26.02.2026 16:05 β€” πŸ‘ 76    πŸ” 42    πŸ’¬ 1    πŸ“Œ 4
Post image

We made FLIP2, a protein fitness benchmark spanning seven new datasets, including enzymes, protein-protein interactions, and light-sensitive proteins, as well as splits that measure generalization relevant to real-world protein engineering campaigns.

25.02.2026 21:25 β€” πŸ‘ 51    πŸ” 14    πŸ’¬ 1    πŸ“Œ 1
Preview
Clinical-grade autonomous cytopathology through whole-slide edge tomography - Nature This study presents a clinical-grade autonomous pipeline combining high-resolution whole-slide tomography, edge computing and artificial intelligence, achieving high accuracy in cervical cytology and ...

www.nature.com/articles/s41...

26.02.2026 02:30 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Panel A: A figure showing the change in the sum of diameters of the target lesions across tumor types. 

Panel B: A figure showing the overall duration of treatment and the time to first response observed in 46 patients treated with a dose in the observed efficacious-dose range who had wild-type KRAS.

Panel A: A figure showing the change in the sum of diameters of the target lesions across tumor types. Panel B: A figure showing the overall duration of treatment and the time to first response observed in 46 patients treated with a dose in the observed efficacious-dose range who had wild-type KRAS.

In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%. Full PYNNACLE study results: nej.md/3OIQC5P

#MedSky #Oncology

25.02.2026 22:10 β€” πŸ‘ 7    πŸ” 4    πŸ’¬ 1    πŸ“Œ 1

This seems super important for endogenous lineage tracing!!

β€œIn vivo lineage tracing across human tissues using methylation barcodes in the protocadherin gene cluster”

www.biorxiv.org/content/10.6...

24.02.2026 23:42 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

And that would be β€œfed” to BlueSky when it β€œasks” for a thumbnail? I have no idea how this works haha.

24.02.2026 20:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Ah I see. Perhaps on submission you could have the option of designating a figure for the thumbnail for social media posts?

24.02.2026 20:04 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Post image

Something like this:

24.02.2026 17:52 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

@richardsever.bsky.social, I've noticed that when you link to BioRxiv papers in BlueSky that no thumbnail populates with the paper's title or other info? Might make it easier to post if the link automatically led to the inclusion of this info.

24.02.2026 17:51 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0

"Discovery of chromatin-based determinants of azacytidine and decitabine anti-cancer activity"

www.biorxiv.org/content/10.1...

24.02.2026 17:49 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Preview
Fat Signing Bonuses, and Concierge Service, for Family Doctors

Canadian provinces have to compete for primary care doctors, often from other countries, because they reduced the funding needed to train new Canadian medical students and doctors.

www.nytimes.com/2026/02/22/w...

23.02.2026 17:58 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Clinical progress of engineered cellular immunotherapies for autoimmunity - Nature Biotechnology Engineered cellular immunotherapy shows great potential for treating autoimmune diseases. Payne and colleagues review emerging clinical data of the most recently developed technologies.

Engineered cellular immunotherapies for autoimmunity are advancing fast, with many now in clinical trials. This @natbiotech.nature.com Review breaks down what emerging data reveal β€” and where the field is heading next. www.nature.com/articles/s41...

18.02.2026 09:18 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Fantastic teamwork by Irene Schwartz & Valentina Budroni from the lab of @versteegga.bsky.social @maxperutzlabs.ac.at together with colleagues in our SFB consortium & beyond πŸ‘Great to see the story out @natcomms.nature.com
πŸ”— www.nature.com/articles/s41...

22.02.2026 10:36 β€” πŸ‘ 11    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
Post image

Spending lots of time to modify same PDB and finally I could make image with ligting molecule.

22.02.2026 06:29 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school.

20.02.2026 14:33 β€” πŸ‘ 11    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0
Preview
GitHub - ravishar313/PyMolAI: PyMolAI provides Agentic interface to PyMol workflows, built on top of Open Source version of PyMol. PyMolAI provides Agentic interface to PyMol workflows, built on top of Open Source version of PyMol. - ravishar313/PyMolAI

PyMolAI! "PyMolAI provides Agentic interface to PyMol workflows, built on top of Open Source version of PyMol."

Sounds like it could be quite useful.

github.com/ravishar313/...

21.02.2026 18:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Paediatricians’ blood used to make new treatments for RSV and colds Antibodies harvested from the blood of paediatricians are up to 25 times better at protecting against the common respiratory infection RSV than existing antibody therapies, and are now being developed as preventative treatments

Antibodies harvested from the blood of paediatricians are up to 25 times better at protecting against the common respiratory infection RSV than existing antibody therapies, and are now being developed as preventative treatments

20.02.2026 06:55 β€” πŸ‘ 423    πŸ” 123    πŸ’¬ 13    πŸ“Œ 66

www.biorxiv.org/content/10.6...

20.02.2026 17:27 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
With federal research funding uncertain, states debate new science initiatives A handful of states are considering initiatives to increase funding for scientific research as uncertainty around federal dollars has grown.

A handful of states are considering initiatives to increase funding for scientific research as uncertainty around federal dollars has grown. www.statnews.com/2026/02/20/s...

20.02.2026 15:25 β€” πŸ‘ 20    πŸ” 5    πŸ’¬ 2    πŸ“Œ 0

β€œIf you’ve ever wondered what you could do with a few more hours in the day, Osmond suggests an answer. A rough calculation suggests that she has been conscious for thirteen years longer than her average peer from elementary school.”

19.02.2026 17:07 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0