Kavitha Scranton

Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils Human T cell responses are often studied using blood, yet most T cells reside in tissues. By comparing T cell receptor repertoires from millions of T cells from autologous tonsils and blood, Sureshcha...

We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...

Immunity by Cell Press | LinkedIn Immunity by Cell Press | 45 followers on LinkedIn. Cutting-edge research in immunology from around the world, and commentaries by thought leaders. | Immunity publishes the most important advances in i...

Immunity is now on LinkedIn! Follow us if you love #immunology! And if you don't already love immunology, maybe we'll change your mind 😀https://www.linkedin.com/company/immunity-cellpress

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A…

Our new paper reveals that chronic active MS lesions feature CD8⁺ T cell niches with lipid-laden, inflamed microglia. IFN-γ drives cholesterol buildup, linking dysregulated lipid metabolism to inflammation and meurodeg.
Check it out @cp-immunity.bsky.social

www.sciencedirect.com/science/arti...

How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.

cell.com/immunity/ful...

Thanks and congratulations to all contributors

For those of you joining us for the editors panel at #RTN2025, please bring your questions! We have more editors than I've ever seen at a single meeting, so this is your chance to get answers to all of your burning questions! @genelayinstitute.bsky.social @rtnconference.bsky.social

Looking forward to #RTN2025 today! Excited for some #neuroimmunology! If you'll be there, please look for me and say hello! @genelayinstitute.bsky.social @rtnconference.bsky.social
genelayinstitute.org/rtn/#program

#CSNeuroimmune25 @danmucida.bsky.social
talking about food allergy and neuroimmune response to helminth infection @cp-neuron.bsky.social

YouTube video by Daniel R. Saban Supplemental Video 2_Littleton et al_2025

#CSNeuroimmune25 Come learn about a novel neuro immune niche that underpins touch! Littleton Tues P2.38 13:00-14:30 youtu.be/BAtzNKj4wxA?si…

Getting ready for #CSNeuroimmune25 tomorrow in NYC! Excited to see everyone, and looking forward to some cool #neuroimmunology! @cp-neuron.bsky.social @cp-immunity.bsky.social www.cell-symposia.com/neuroimmunol...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

The high (I)COSt of costimulation for exhausted T cells ICOS agonists are being investigated for cancer immunotherapy based on the idea that they will reinvigorate exhausted CD8+ T cell anti-cancer immunity. Humblin et al. unexpectedly find the opposite—th...

It was a privilege and a pleasure for both myself and @menezesnmaria.bsky.social‬ to preview a great upcoming article in @cp-immunity.bsky.social‬ by @kamphorstlab.bsky.social‬ showing an unexpected inhibitory role for ICOS in exhausted CD8+ T cells.

www.cell.com/immunity/abs...

Neural tuners of lung immunity Pulmonary immunity must strike a precise balance between protecting the delicate mucosal tissue from environmental threats and preserving its vital gas-exchange function. In this issue of Immunity, Li...

Thanks to Dr. Pinho-Ribeiro for previewing our latest work in the current issue of Immunity. @cp-immunity.bsky.social @kavithascranton.bsky.social

Neural tuners of lung immunity: Immunity cell.com/immunity/ful...

cell.com/immunity/ful...

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…

A new function for an ancient innate immune stimulus.
Zanoni et al report that oxidized lipids control IL-10 expression, impacting host defense and disease. Kudos to the authors on this important discovery www.sciencedirect.com/science/arti...

#ChromatinPower #WhatADay! After our paper @cp-immunity.bsky.social (free link 👉 authors.elsevier.com/a/1lS0g3qNrU-i…) happy for our tiny contribution to @xuzhoulab.bsky.social Medzhitov &co amazing paper @cp-cell.bsky.social showing pH controls inflammation via chromatin remodeling! Free link👇

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation f monocyte-derived inflammatory CCRL2+ macrophages Parasympathetic neuronal dysfunction is associated with heart failure, yet the underlying mechanism is poorly understood. Here, Li et al. demonstrate that optogenetic activation of the vagus nerve pre...

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Early discounted registration ends June 27th for #CSNeuroimmune25, Sept 7–9, NYC! Explore cutting-edge #neuroimmunology and engage with experts in the field. Keynotes: David Julius & Susan Kaech hubs.li/Q03qS95l0 @cp-neuron.bsky.social @kavithascranton.bsky.social @cellpress.bsky.social

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...

Cell Symposia

Explore breakthroughs in #cancer #immunology with global leaders.
#CellSymposia: The cancer-immunity cycle
Keynotes: Ira Mellman & Carl June
Abstract submission deadline: July 25
Sitges, Spain | Nov 2–4, 2025
http://dlvr.it/TLX7WS

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

Meet the keynote speakers at #CSNeuroimmune25: David Julius (UCSF) & Susan Kaech (The Salk Institute) NYC | Sept 7–9, 2025 Early registration discount ends June 27!
hubs.li/Q03sQJjj0 @tcellogic.bsky.social @cp-neuron.bsky.social @salkinstitute.bsky.social #neuroimmune

Our new Immunity paper is in print—and that an oil painting I made was chosen for the cover 😊

It visualizes “affinity birth,” the generative force of SHM creating new antibody specificities beyond V(D)J.

#Immunology #AffinityBirth #SciArt #Bcells #SHM

Also happy to set up a zoom call if you want to talk before then!

So sorry to have missed you! I’ll see you in Sept at the Neuroimmune Axis Cell Symposium, right? #CSNeuroimmune25

Had a great time at the CSHL Senescence & Aging meeting this week #cshlsymp25 @cshlmeetings.bsky.social. Enjoyed a wonderful dinner last night with scientists and supporters of CSHL, including the amazing #SusanLucci!

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social

www.cell.com/immunity/abs...

Immunity editor @kavithascranton.bsky.social is at the CSHL Senescence & Aging meeting this week #cshlsymp25 Look for her and say hello! She's looking forward to hearing about your work!