Sarah Merkling

Super proud of our consortium @ibeidlabex.bsky.social achievements, and so grateful for all the support they provided to me as a postdoc and young PI @pasteur.fr @inserm.fr @santepubliquefrance.fr @anses-fr.bsky.social @cnrs.fr

Stage-resolved metabolomics reveals the methionine cycle as a key regulator of Aedes aegypti development and dengue virus susceptibility Developmental transitions in the mosquito Aedes aegypti are central to vector competence and disease transmission, yet the underlying metabolic programs remain poorly defined. Here, we use untargeted ...

Kicking off the new year with mosquitoes, metabolomics, & arboviruses! 🥳

🦟Our new preprint is out! We mapped the metabolism of the Aedes aegypti mosquito across its life cycle to find new ways to fight dengue virus.

Check it out on: doi.org/10.64898/202...

#VectorBiology #Metabolomics #Mosquito

That’s awesome ! Welcome and congratulations 🎉

Still looking for our perfect doctoral candidate as part of @evomg-dn.bsky.social - come and join us to work on the evolutionary pressures that shape gene expression and disease in the uterus!

Please RT (or is it RB? not sure how our lingo has changed!)

Sarah Merkling wants to "pasteurize" mosquitoes! At the Institut Pasteur, Sarah Merkling's research focuses on a topic that is still largely unknown: interactions between mosquitoes and viruses. She boldly devises novel strategies based on state-of-...

🦟 Can we "pasteurize" mosquitoes to stop dengue & Zika?

Sarah Merkling @merklinglab.bsky.social uses AI + CRISPR to analyze stomach cells and understand why some mosquitoes spread viruses while others don't.

Goal: Make disease-carrying mosquitoes harmless.
#Zika #Dengue

👩‍🔬J'ai commencé un kit de démarrage "chercheuses en France" go.bsky.app/TBEzKC #FemmesEnScience

J'ai besoin de votre aide pour le remplir et donner de la visibilité aux chercheuses que vous connaissez et qui sont sur Bluesky !
▶️Taguez celles que vous connaissez, je les ajoute !

Virology lost one of his monuments, David Baltimore. To learn more about him and his contributions, I recommend (re)-listening to this great TWIV episode : www.microbe.tv/twiv/twiv-10...

@elodiecouderc.bsky.social is on 🔥 this month ! Our review (which the literature really missed, imho) giving an historical perspective on the methods used to study of mosquito-virus interactions in now online at @cp-trendsmicrobiol.bsky.social. Check it ou here: www.cell.com/trends/micro...

RIP Margaret Rossiter, who coined the phrase the Matilda Effect (amongst many others), a phenomenon too many women will have seen first hand

Thank you to our funders @pasteur.fr @ibeidlabex.bsky.social @sorbonne-universite.fr @agencerecherche.bsky.social @cnrsecologie.bsky.social for supporting our work!

👏So proud to share @elodiecouderc.bsky.social work on the role of Vago-like genes in mosquito immunity. Please read her thread to get a sneak-peek of our work and find the full study here: rdcu.be/eCPmG

Yes! This is cytochrome P4503A4 - it is a very large family and their activity spans from detoxification, metabolism and many more cellular processes. In our case, the exact mechanism linking our P450 with dengue virus is unknown - might be metabolism (my first guess), or something else ...

Thank you Alain!

Thank you Olaya !

Thank you ! So much more work to do indeed :)

This was one of the most exciting, exploratory, long and difficult project I ever got to work on and I thank everyone who contributed, shared ideas and asked questions about it at meetings. Thanks to our funders @pasteur.fr @agencerecherche.bsky.social for their continuous support !

It also raises new questions about the role of metabolism in DENV infection and the unexplored/mysterious link between DENV susceptibility and insecticide resistance. (2/3)

Our study is now published in @natcomms.nature.com and describes the 1st definitive identification of genetic variants linked to DENV susceptibility in Aedes aegypti mosquitoes. (1/3)

David Hall & @vectorimmunity.bsky.social highlight @merklinglab.bsky.social & colleagues’ Cell Genomics article on #mosquito cellular responses in #midgut & #fatbody after #bloodfeeding. #Aedes #aegypti #scRNAseq #Metabolomics @iastateresearch.bsky.social‬ ‬

authors.elsevier.com/a/1lbEr5Eb1x...

go.bsky.app/36RdG8Z

4 research institute march together hand in hand for diversity and inclusion in science © Franck Aubry

© Franck Aubry

© Franck Aubry

🌈 United for diversity in science 🌈
Researchers from Institut Pasteur joined the 2025 Pride March alongside @institutcurie.bsky.social, Les Cordeliers Research Center, @institutcochin.bsky.social @institutimagine.bsky.social

👩‍🔬 Because diverse labs make better science.
#DiversityInScience

🎉 Our study is now published in Cell Genomics ! Thank to our reviewers for helping us further improve our work, and congratulations to @tompvial.bsky.social who lead this project and the entire team that made it possible ! www.cell.com/cell-genomic...

Awesome post-doc position available within the @maringerlab.bsky.social ! I can highly recommend applying to @pirbrightinst.bsky.social - Kevin and Trevor are wonderful PI's to be working with !

Changes to the 2026 and 2027 Work Programmes With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

Planning to apply for #research #funding from the ERC?

From the next application rounds, expect changes to the:

• proposal structure
• evaluation process
• extra funding you can request
• eligibility for Starting & Consolidator #Grants (from 2027)

More 👇 europa.eu/!RPHWvv

Had the pleasure of listening to @ardemp.bskyverified.social’s lecture yesterday at @pasteur.fr - and seeing a live demonstration of the Piezo tattoo !

Wrapped up a 4 seminar Tour de 🇫🇷 with stops in Lyon, Strasbourg, and Paris (IBPS, Pasteur). Had a blast with fellow scientists across the pond, lots of convo about the current US landscape. You might recognize Jean-Marie Lehn, Jean-Pierre Changeux, and Christine Petit. Also: white asparagus season!

A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

Had a wonderful time at the #EMBLChromatin meeting in Heidelberg last week with @sumeyye-ozhan.bsky.social who was sponsored by a @pasteur.fr - @events.embl.org travel award ! @sebbaumgarten.bsky.social ;)

Congratulations on getting the poster prize !! 🥳
Also very nice meeting you at the conference :)

YouTube video by Pasteur Lille Maladie de Lyme : comment s’en protéger ? - Sébastien Bontemps Gallo - 10' de prév'

@sebbontempsgallo.bsky.social , Chercheur @cnrs-hautsdefrance.bsky.social @cnrsbiologie.bsky.social

Maladie de #Lyme : comment s’en protéger ?