Cyrus Harmon

David Botstein | 1942 - 2026 | Online-Tribute.com David was a beloved husband, father, brother, scientist, teacher, mentor, musician, friend, who touched the lives of thousands. David’s wide-ranging scientific career spanned decades with a legacy o…

Farewell to an absolute giant of molecular genetics, David Botstein www.online-tribute.com/DavidBotstein

ITYM Iliad…

Wiley Prize in Biomedical Sciences Gerry Rubin Senior Group Leader HHMI Janelia Research Campus

Celebrating HHMI giant Gerry Rubin today, winner of the Wiley Prize in Biomedical Sciences! Along w/ colleagues, Rubin — founding Exec. Dir. of our Janelia Research Campus — is recognized for mapping connectomes, the wiring diagrams of neurons that underlie how the brain functions: bit.ly/4aXkrs4

So good!

Arguably, one should need stone tablets vetted by a prophet indicating that it’s against doctrine. Anything less runs the risk of being just completely made up or against the will of one’s divine creator(s).

Or, one could just do the exact opposite of everything proscribed in this article. Probably higher odds of success, IMO.

Yes, it’s always satisfying to start (and/or end) with a bingo.

NYT spelling bee game claiming that angulate is not a word.

Srsly? Guess the bee folks have never skied?!?

Very cool!

Democratic messaging about Trump’s “billionaire friends” is horribly misguided. 1) he has no friends. 2) all the grift is for himself and his offspring. That’s it. All the rest is the cost of doing business. Stop blaming anonymous billionaire “friends”.

It’s not unusual.

Earthquake! Small one, thankfully.

Part 1: My Life Is a Lie How a Broken Benchmark Quietly Broke America

I don't know who this guy is (just a disclaimer, I guess), but this is a compelling and arithmetically straightforward explanation of the many predicaments the US finds itself in. Why upward mobility in America is a myth and class warfare is on the rise. Read it over your morning coffee.

Faces deserve a spot!

I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.

A bientôt!

D’oh! WORM genome…

Don’t sleep on ACeDB (I know you mentioned the word genome, but it’s worth calling out separately)!

Sure beats a parking lot!

Yes, and we’ll surely see the mainstream press fall over itself to tell us how the republican brand is dead and that they need to reject fascism and repudiate the orange guy. Hell, The R cand. couldn’t even even crack double digits! What’s that? You say that only applies to the left? Oh, I see. Nvm…

What kind of sociopathic asshat is against dog parks?!?

It was really about white christian nationalism all along…

And sigma has been co-opted by Gen Alpha apparently.

Biomek would be a pretty dope name.

“Our great computers fill the hallowed halls!” 🎶

But, seriously, I love how the LLM refuses to learn “Faith” concepts. Maybe they’re better than we give them credit for being.

If you're talking about who I think you are, I think he has more felony counts against him than Sonny, who had quite a few.

It’s amazing to watch all the “state’s rights” folks turn into unitary executive/monarchists.

Rapid De Novo Antibody Design with GeoFlow-V3

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Rapid De Novo Antibody Design with GeoFlow-V3 [new]
De novo antibody design: Uses a generative model that predicts structure and enables rapid, in silico design, significantly improving hit rates.

#compchem New group preprint: "From Water Networks to Binding Affinities: Resolving Solvation Dynamics for Accurate Protein-Ligand Predictions"

👉Check it out: www.biorxiv.org/content/10.1...
Great work by M. Blazhynska.
#compbio #drugdesign

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Triangle Multiplication Is All You Need For Biomolecular Structure Representations [new]
Streamlined alternative to AlphaFold's pairwise reasoning, replacing triangle attention with Pairmixer, enabling faster, cheaper biomolecular structure prediction.