Hesso Farhan

Postdoc job alert at Institut Jacques Monod in Paris! Interested in fundamental membrane trafficking? We seek a postdoc to study collagen secretion as a model for core principles of how cells and their environment build each other. emploi.cnrs.fr/Offres/CDD/U...

New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇

www.biorxiv.org/content/10.6...

Cdc42 accumulates in aged cells, and reducing its levels extends life span.Two representative WT cells expressing Cdc42-mCherrySW are shown at selected ages and time points (hr: min) from initial loading. White arrowheads indicate cells during or shortly after cytokinesis, when Cdc42 levels are quantified. Black and red arrowheads denote the same cells at other cell cycle stages and cell death, respectively. Scale bar: 3 µm.

Cdc42 is a small GTPase crucial for #CellPolarity, but how does it contribute to #aging when upregulated? This study shows that the ER-anchored chaperone Ydj1 interacts with Cdc42, enhancing its stability & partitioning during asymm #CellDivision & aging in yeast @plosbiology.org 🧪 plos.io/4qz7WaM

Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration. Interesting paper on tagelang Ero1 in macrophages by nanorobots. 🤔 rdcu.be/e3Uxw

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris

ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity
bit.ly/40dNHEE

Endoplasmic reticulum disruption stimulates nuclear membrane mechanotransduction Nature Cell Biology - Shen, Gelashvili and Niethammer developed an inner nuclear membrane tension sensor and demonstrated that ER–nuclear membrane contiguity acts as a mechanical buffer.

Joe Shen’s and Zaza Gelashvili’s work on the role of the ER in nuclear membrane mechanotransduction finally came out in a journal!

Nothing.

ERC success rates are tanking and the move is... even bigger grants for fewer people? smh

Nice paper from Kota @saitolab.bsky.social! Balanced phosphorylation of TANGO1 and Sec16A keep ER exit sites stable and functional.
Do cells maintain this dynamically to keep secretory machinery primed and responsive to changing cargo loads or environmental signals?
www.nature.com/articles/s41...

Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...

q.e.d Science Critical Thinking AI for constructive criticism and science evaluation

or just q.e.d. it www.qedscience.com

Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...

#ER_literature #Migration #Organelles

the word congratulations is surrounded by multicolored confetti ALT: the word congratulations is surrounded by multicolored confetti

Congrats Sara

What do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies rupress.org/jcb/article/...
#ER_literature

Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy Depletion of the ER stress sensor IRE1α can reduce paclitaxel-induced peripheral neuropathy in mice.

Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy | Science Translational Medicine www.science.org/doi/10.1126/...

Economics Nobel prize won by researchers who showed how science boosts growth Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

Joel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development.

go.nature.com/4hj9NNV

Bei Grundlagenforschung kürzen? Keine gute Idee! Kein Geist, kein Sinn. Österreich braucht keine männliche MINT-Monokultur, sondern eine starke und vielfältige Wissenschaft.

Bei #Grundlagenforschung kürzen? Keine gute Idee! so die Philosophin @asmeincke.bsky.social in ihrem Gastkommentar in @diepressecom.bsky.social. Denn Österreich brauche eine starke und vielfältige Wissenschaft.
@fwf-at.bsky.social @oeaw.bsky.social

Bessere Ideen 👉
www.diepresse.com/20152064/bei...

Check out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:

It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.

Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control Nature Cell Biology - Zhang, Lahry, Cipurko et al. show that the microbial metabolites queuine and preQ1 modify the same host tRNA. PreQ1-tRNA reduces cell proliferation, slows tumour growth,...

The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs.
rdcu.be/eHw46

Beautiful work which supports a role for the ER in mechanobiology.

Quantitative imaging of lipid transport in mammalian cells - Nature Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

Nature research paper: Quantitative imaging of lipid transport in mammalian cells

go.nature.com/4mmSygd

Establishment of the phagophore–ERES membrane contact site initiates phagophore elongation Nature Structural & Molecular Biology - Gómez-Sánchez et al. show that generation of phagophore–endoplasmic reticulum exit sites (ERES) membrane contact sites, mediated by Atg2...

New paper by the Reggiori and Ungermann Labs showing using a yeast model that contact sites between the phagophore and ERES are important for phagophore elongation.
rdcu.be/ezUeZ

Great preprint showing that COPII vesicles do exist in vicinity of ERES. Very interesting.

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL

Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social

The endoplasmic reticulum proteostasis network and bone disease Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...

Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...

Targeting proteostasis in multiple myeloma through inhibition of LTK Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX

External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics Plasma membrane–endoplasmic reticulum physical tethering is a mechanotransduction pathway.

External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics | Science Advances www.science.org/doi/10.1126/...