Jackson Cahn

More on Trump’s nominee to lead the office investigating Jack Smith:

➡️ He said that the descendants of slaves should pay reparations to the descendants of slave owners

➡️ He urged Congress to make J6 a national holiday

➡️ He called for Trump’s birthday to be made a national holiday (“MAGA Day”)

Every day a new parade of horribles.

There is so much amazing science coming out of UCLA.

Smithsonian removes Trump from impeachment exhibit in American History Museum A temporary placard, on display since 2021, described the president's historic impeachments. Officials said the exhibit was restored to an earlier version following a review of legacy content.

Okay but what the fuck is this?

www.washingtonpost.com/entertainmen...

From left to right, Dr. Albert Mulenga, William Tae Heung Kim, Dr. Thu Thuy Nguyen, Dr. Alex Kiarie Gaithuma, Dr Hassan Hakimi and Emily Bencosme Cuevas. Kim is a Texas A&M researcher who was detained in San Francisco last Monday despite being a permanent resident of the United States and a green card holder. COURTESY OF TEXAS A&M UNIVERSITY

I NEED to tell you the story of Tae Heung “William” Kim.

He's a graduate student at Texas A&M where he's working on a vaccine for Lyme disease.

He's a *legal permanent resident* of the United States.

And he's been in ICE detention for 12 days & counting, transferred Tuesday to South Texas.

What journal is this that gives such granular status updates?

“I trust it as far as I can throw it” is basically mass spec

Determining how you feel about things by throwing them real hard

Super exciting resource and analysis, Kevin. And love the tribute to Dayhoff.

In 1965, Margaret Dayhoff published the Atlas of Protein Sequence and Structure, which collated the 65 proteins whose amino acid sequences were then known.

Inspired by that Atlas, today we are releasing the Dayhoff Atlas of protein sequence data and protein language models.

About time the investor class started paying attention to the destruction of the biomedical innovation pipeline.

Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes Azaspiro[2.y]alkanes are increasingly valuable scaffolds in pharmaceutical drug discovery; however, an asymmetric catalytic method for their synthesis remains unknown. Here, we present a stereodiverge...

I'm really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with some help from #directed evolution to do chemistry not known in nature (and really hard for humans, too). @caltechcce.bsky.social
pubs.acs.org/doi/10.1021/...

Really exciting work.

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Hard to overstate how bleak this is.

Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we disc...

Here's a fun perspective piece on Cyanobacteria as prolific natural product producers with great potential for drug discovery. Thanks especially to @philmuslab.bsky.social for ringleading and letting us contribute!
pubs.rsc.org/en/content/a...

These people are so dumb.

Simulating enzyme catalysis with electrostatically embedded machine learning potentials To simulate enzyme reactions, multiscale quantum mechanics/molecular mechanics (QM/MM) approaches are well established and popular. However, accurately and efficiently estimating enzyme activity is a ...

🚨 Preprint! 🚨
We show that enzyme catalysis can be accurately simulated with ML/MM, >1000x faster than with DFT/MM!

Combining gasphase MLPs with our EMLE approach, we show ML(EMLE)/MM fully captures catalysis in two enzyme reactions.

See also:
github.com/chemle/

doi.org/10.26434/che...

Fantastic opportunity to start your independent career at the JIC here. Great startup package. Repost = nice. Thank you!!!

Postdoctoral researcher on enzyme characterization and enzyme engineering The Faculty of Science / the Institute for Biology is looking for a: Postdoctoral researcher on enzyme characterization and enzyme engineering Vacancy number: 15834   Project description We are hiring...

Please share: I am hiring a postdoc that will work on enzyme characterization and engineering in the frame of the EU consortium project C5.

Read all details here and apply until August 10: www.universiteitleiden.nl/en/vacancies...

Due to some vagaries of ductwork, the coolest room of my house, my office, is directly adjacent to the warmest room, the laundry room. The temperature difference can be as high as 6-7°F when the AC is at full crank. Trying to figure out how to use this to generate electricity...

getting in a fistfight because me and the boys can't decide if "making your robot talk like Hitler" is a Simpsons Homer & Mr Burns B-plot episode, a Community Pierce & Abed A-plot episode, a 30 Rock Jack & Pete C-plot episode, or a Data & Geordi 2-part cliffhanger TNG episode

In our recently submitted grants we had to change “traumatic brain injury” to “concussive brain injury” and “male and female mice” to “male and non-male mice” because traumatic and female are now verboten words that can get our grants killed. It’s insanity.

Duke appears to have lost NIH grants because they used the prefix "trans" in reference to disease transmission, transgenic genetic material, translational studies, or signal transduction www.dukechronicle.com/article/2025...

They're afraid of what will happen when they cross Trump, so they're taking the biggest bureaucratic punt they can to postpone it.

Not even hiding it.

Less Gannt charts, more gannet charts

"National Science Foundation Surprise: Employees Being Relocated to Accommodate Secretary of HUD’s Palatial New Office"

Here's the official union statement on the HUD takeover.

Small correction that's not included in the screenshot: "Correction: currently 1,833 NSF employees work in the NSF headquarters building."