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Jackson Cahn

@jkbcahn.bsky.social

Learning from evolution to make drugs with enzymes.

351 Followers  |  391 Following  |  113 Posts  |  Joined: 23.08.2023
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Posts by Jackson Cahn (@jkbcahn.bsky.social)

Tagging Gov @mikiesherrill.bsky.social

24.02.2026 18:16 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We don't always win the Super Bowl, but when we do we absolutely humiliate the other team #12

09.02.2026 03:27 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We're sliding into a polio-ridden runaway-warming white-supremacist fascist dystopia.

But Jake Bobo just caught a touchdown pass and that still makes me happy.

26.01.2026 01:34 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Heavily armed conservative protesters at the Michigan state capitol in April 2020.

Heavily armed conservative protesters at the Michigan state capitol in April 2020.

"Who would bring a gun to a protest?" mfs when they're the ones protesting.

25.01.2026 16:17 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

FYI: Seattle

#ICE #ICEWATCH

24.01.2026 18:10 β€” πŸ‘ 51    πŸ” 44    πŸ’¬ 4    πŸ“Œ 1

Just staggered by the complete moral void of not even *pretending* to wait for more information before pivoting to β€œthe opponent of the state deserved it.” It is so insanely depraved. Soulless.

24.01.2026 19:34 β€” πŸ‘ 9392    πŸ” 1989    πŸ’¬ 144    πŸ“Œ 54
Preview
BREAKING: Federal agent shoots man in south Minneapolis A Bring Me The News reporter was near the scene, and recorded multiple gunshots.

β€œFederal agents briefly detained our reporter at the scene, who says he was tackled to the ground and had a gun put in his face.”

24.01.2026 15:46 β€” πŸ‘ 4979    πŸ” 2281    πŸ’¬ 74    πŸ“Œ 94

The Seahawks defense was so dominant that the team scored 41 points and everyone's like "the offense did ok too I guess"

18.01.2026 04:46 β€” πŸ‘ 135    πŸ” 9    πŸ’¬ 5    πŸ“Œ 1
Preview
Rational engineering of lipid-binding probes via high-throughput protein-lipid interaction screening Lipid-binding domains, originally isolated from natural proteins, are useful tools essential for analyzing membrane lipids in cells, and their applications are varied. Yet, there is no general strateg...

9. Directed evolution campaigns yield new lipid-binding domains from a variety of protein scaffold precursors, from @takinishimura.bsky.social and Noboru Mizushima, on @biorxiv-cellbio.bsky.social www.biorxiv.org/content/10.1...

05.01.2026 14:48 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
Matt Walsh tweeted last year: "We've spent the last 25 years bringing "freedom" and "democracy" to countries around the globe while our own country has been systematically invaded and now our largest cities are run by foreigners and communists. If you want to know why I'm so avowedly non-interventionist, this is why."

Then he tweeted today: ""This is a war for oil!!!!!"

First of all, the "war" lasted like 90 minutes. Second, going to war to secure vital resources for your own people is totally legitimate. Why should we allow some third world communist shithole to control trillions of dollars worth of oil?"

Matt Walsh tweeted last year: "We've spent the last 25 years bringing "freedom" and "democracy" to countries around the globe while our own country has been systematically invaded and now our largest cities are run by foreigners and communists. If you want to know why I'm so avowedly non-interventionist, this is why." Then he tweeted today: ""This is a war for oil!!!!!" First of all, the "war" lasted like 90 minutes. Second, going to war to secure vital resources for your own people is totally legitimate. Why should we allow some third world communist shithole to control trillions of dollars worth of oil?"

Laura Loomer tweeted last year: "I’m America First, I don’t support β€œRegime Change”. I went on @Bannons_WarRoom to talk about Chinese aggression in Venezuela and why we need to designate the Muslim Brotherhood as a foreign Islamic terrorist organization."

Then she tweeted yesterday: "Maduro has arrived at the DEA office in Manhattan. He was transported in an armored motorcade after being transported in a blindfold via helicopter & then by plane to New York after his compound in Caracas was raided by US Special Forces.

Proud to be an American today!

USA πŸ‡ΊπŸ‡Έ"

Laura Loomer tweeted last year: "I’m America First, I don’t support β€œRegime Change”. I went on @Bannons_WarRoom to talk about Chinese aggression in Venezuela and why we need to designate the Muslim Brotherhood as a foreign Islamic terrorist organization." Then she tweeted yesterday: "Maduro has arrived at the DEA office in Manhattan. He was transported in an armored motorcade after being transported in a blindfold via helicopter & then by plane to New York after his compound in Caracas was raided by US Special Forces. Proud to be an American today! USA πŸ‡ΊπŸ‡Έ"

Catturd tweeted last year: "Name one U.S. inspired regime change that hasn’t ended in absolute disaster."

Then he tweeted yesterday: "Venezuela is now more free than New York City."

Catturd tweeted last year: "Name one U.S. inspired regime change that hasn’t ended in absolute disaster." Then he tweeted yesterday: "Venezuela is now more free than New York City."

Will Chamberlain tweeted last year: "The Republican Party is no longer the party of regime change and endless wars

If you want to be its standard-bearer that is a non-negotiable position"

Then he tweeted yesterday: "I can think of few better uses of my tax dollars than black-bagging the head of a foreign narco-trafficking organization that enriches itself by addicting and poisoning my fellow Americans"

Will Chamberlain tweeted last year: "The Republican Party is no longer the party of regime change and endless wars If you want to be its standard-bearer that is a non-negotiable position" Then he tweeted yesterday: "I can think of few better uses of my tax dollars than black-bagging the head of a foreign narco-trafficking organization that enriches itself by addicting and poisoning my fellow Americans"

amazing how the entire machine can pivot within 24 hours. no need to slowly upsell the argument; just issue new marching orders

05.01.2026 06:50 β€” πŸ‘ 27108    πŸ” 7937    πŸ’¬ 590    πŸ“Œ 597

this is your mission. our pedophile president needs you to jump out of a helicopter to kidnap a head of state and his wife so some oil ceos can make a lot of money. we’ll be watching from a resort in florida that still serves wedge salad and checking how many retweets we get. good luck soldier

03.01.2026 22:57 β€” πŸ‘ 23829    πŸ” 6725    πŸ’¬ 186    πŸ“Œ 154

Maduro is a brutal and oppressive dictator of Venezuela.

Trump has no legitimate legal basis for military action against Venezuela under United States or international law.

Both of those facts are simultaneously true.

03.01.2026 09:00 β€” πŸ‘ 11506    πŸ” 2835    πŸ’¬ 535    πŸ“Œ 183

Did we just do a fucking coup in Venezuela?

03.01.2026 10:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Weird way to phrase it. It's owned by an Israeli company, not the state.

30.12.2025 23:28 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

In 2005 Benedict became Pope and the Seahawks won 13 games and went to the Super Bowl

In 2013 Francis became Pope and the Seahawks won 13 games and went to the Super Bowl

In 2025 Leo became Pope and the Seahawks have won 13 games...

29.12.2025 06:13 β€” πŸ‘ 622    πŸ” 88    πŸ’¬ 49    πŸ“Œ 10

You've just opened a chemistry themed pub, what are you calling it?

The H-Bar
(Δ§)

#chemsky

29.12.2025 06:07 β€” πŸ‘ 14    πŸ” 0    πŸ’¬ 2    πŸ“Œ 1
News Team,
Thank you for the notes and texts. I apologize for not reaching out earlier.
I learned on Saturday that Bari Weiss spiked our story, INSIDE CECOT, which was supposed to air tonight. We (Ori and I) asked for a call to discuss her decision. She did not afford us that courtesy/opportunity.
Our story was screened five times and cleared by both CBS attorneys and Standards and Practices. It is factually correct. In my view, pulling it now-after every rigorous internal check has been met is not an editorial decision, it is a political one.
We requested responses to questions and/or interviews with DHS, the White House, and the State Department. Government silence is a statement, not a VETO. Their refusal to be interviewed is a tactical maneuver designed
to kill the story.
If the administration's refusal to participate becomes a valid reason to spike a story, we

News Team, Thank you for the notes and texts. I apologize for not reaching out earlier. I learned on Saturday that Bari Weiss spiked our story, INSIDE CECOT, which was supposed to air tonight. We (Ori and I) asked for a call to discuss her decision. She did not afford us that courtesy/opportunity. Our story was screened five times and cleared by both CBS attorneys and Standards and Practices. It is factually correct. In my view, pulling it now-after every rigorous internal check has been met is not an editorial decision, it is a political one. We requested responses to questions and/or interviews with DHS, the White House, and the State Department. Government silence is a statement, not a VETO. Their refusal to be interviewed is a tactical maneuver designed to kill the story. If the administration's refusal to participate becomes a valid reason to spike a story, we

have effectively handed them a "kill switch" for any reporting they find inconvenient.
If the standard for airing a story becomes
"the government must agree to be
interviewed," then the government effectively gains control over the 60 Minutes broadcast.
We go from an investigative powerhouse to a stenographer for the state.
These men risked their lives to speak with us.
We have a moral and professional obligation to the sources who entrusted us with their
stories. Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless.
CBS spiked the Jeffrey Wigand interview due to legal concerns, nearly destroying the credibility of this broadcast. It took years to recover from that "low point." By pulling this story to shield an administration, we are repeating that history, but for political optics rather than legal ones.

have effectively handed them a "kill switch" for any reporting they find inconvenient. If the standard for airing a story becomes "the government must agree to be interviewed," then the government effectively gains control over the 60 Minutes broadcast. We go from an investigative powerhouse to a stenographer for the state. These men risked their lives to speak with us. We have a moral and professional obligation to the sources who entrusted us with their stories. Abandoning them now is a betrayal of the most basic tenet of journalism: giving voice to the voiceless. CBS spiked the Jeffrey Wigand interview due to legal concerns, nearly destroying the credibility of this broadcast. It took years to recover from that "low point." By pulling this story to shield an administration, we are repeating that history, but for political optics rather than legal ones.

We have been promoting this story on social media for days. Our viewers are expecting it.
When it fails to air without a credible
explanation, the public will correctly identify this as corporate censorship. We are trading 50 years of "Gold Standard" reputation for a single week of political quiet.
I care too much about this broadcast to watch
it be dismantled without a fight.
Sharyn

We have been promoting this story on social media for days. Our viewers are expecting it. When it fails to air without a credible explanation, the public will correctly identify this as corporate censorship. We are trading 50 years of "Gold Standard" reputation for a single week of political quiet. I care too much about this broadcast to watch it be dismantled without a fight. Sharyn

Per NY Times’s Michael Grynbaum on X, this is Sharyn Alfonsi’s email to her β€œ60 Minutes” colleagues in full:

22.12.2025 03:37 β€” πŸ‘ 27407    πŸ” 10851    πŸ’¬ 679    πŸ“Œ 958

These are amazing, please make more.

08.12.2025 19:52 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Demon escapes because you didn't have enough wizards to form a binding circle? Problematic mage gap.

20.11.2025 02:44 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

This is, like, very illegal, right?

19.11.2025 19:35 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Can't Help Falling In Love With A Vaccine: How Polio Campaign Beat Vaccine Hesitancy This isn't the first big vaccine rollout, and the past holds lessons for the pandemic present. Here's a look at how the polio vaccine overcame U.S. hesitancy.

www.npr.org/sections/hea...

19.11.2025 17:28 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Well we did, in 1955. I don't know how to recapture that magic, short of polio becoming common again 😬

19.11.2025 16:39 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

The polio vaccine?

19.11.2025 14:24 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

bsky.app/profile/jkbc...

19.11.2025 02:26 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Post image Post image Post image Post image

Alternate between AlphaFold3 "hallucinations" and fixed-backbone sequence design to generate or optimize proteins.

www.biorxiv.org/content/10.1...

18.11.2025 22:39 β€” πŸ‘ 11    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

The shutdown delayed applications opening for the NIST Summer Undergraduate Research Fellowship (SURF) program, but their website says they will start accepting applications 12/1. www.nist.gov/surf #chemsummer

There’s an example of a project from last year in the quoted post

17.11.2025 13:13 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
Post image

NEW pub in @science.org πŸ₯³

Is it sponges (panels A & B) or comb jellies (C & D) that root the animal tree of life?

For over 15 years, #phylogenomic studies have been divided.

We provide new evidence suggesting that...

πŸ”—: www.science.org/doi/10.1126/...

13.11.2025 20:33 β€” πŸ‘ 284    πŸ” 130    πŸ’¬ 14    πŸ“Œ 30

Other than the scientific findings, the major lesson here is don't leave academia and think you'll finish your big paper in your spare time. You won't.

14.11.2025 12:48 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

This paper was the main focus of work during my postdoc, and almost exactly 5 years after leaving ETH it's being published at last. I'm incredibly grateful to Maria, Alena, JΓΆrn, and the rest of the team who turned a big pile of genomes, annotations, and spreadsheets into an incredible paper.

14.11.2025 12:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

With this dataset, we can start thinking about the evolution of this bacterial taxon, of their symbiotic relationship with sponges, and of their biosynthetic complement.

14.11.2025 12:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0