🏳️‍🌈🪱🧬's Avatar

🏳️‍🌈🪱🧬

@rogerdjp.bsky.social

Neurogeneticist studying the neurobiology of behaviour and physiology in Caenorhabditis elegans. See monash.edu/discovery-institute/pocock-lab

42 Followers  |  50 Following  |  5 Posts  |  Joined: 14.11.2024  |  1.3151

Latest posts by rogerdjp.bsky.social on Bluesky

Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress Animals integrate environmental and internal cues to maintain homeostasis and health. The mitochondrial stress response is an essential cytoprotective mechanism, and priming its activation provides a survival advantage. Here, we show that the Caenorhabditis elegans receptor guanylyl cyclase GCY-9 regulates neuropeptide signalling from carbon dioxide sensing neurons to govern a non-canonical mitochondrial stress response in the intestine. This stress response induces atypical mitochondrial chaperone transcription, confers mitochondrial stress resistance, and increases mitochondrial membrane potential and respiration. GCY-9 loss disrupts pathogen avoidance, leading to indiscriminate feeding. We show that starvation decreases GCY-9 expression and propose that the resultant cytoprotective program is launched to offset risks associated with this behaviour. Thus, environmental sensing by peripheral neurons can pre-emptively enhance systemic mitochondrial function in response to metabolic uncertainty. One-Sentence Summary Protecting mitochondria by integrating environmental signals ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, GNT1137645, GNT2000766

Check out our pre-print on how gas sensing neurons enable animals to anticipate mitochondrial stress!

www.biorxiv.org/content/10.1...

07.07.2025 05:14 — 👍 5    🔁 2    💬 1    📌 0

What a wonderful International Worm Meeting. Thanks to Cathy Savage-Dunn @cswormlab.bsky.social
and Baris Tursun @baristursun.bsky.social for organising #worm25!!

Meeting old friends and new, a Nobel Prize celebration, and finding out that worms can hear! The talks and posters were exceptional.

05.07.2025 02:42 — 👍 10    🔁 0    💬 0    📌 0

“Do you have any advice for aspiring young scientists?”

“Do genetics.” *mic drop*

#worm25

30.06.2025 02:01 — 👍 92    🔁 22    💬 0    📌 1

Thanks Dave!

29.06.2025 21:19 — 👍 1    🔁 0    💬 0    📌 0
Post image

Functional depletion of MDT-29 during the larval germ line development in #Celagans boosted fecundity through an expansion of the germline stem cell pool and decreased germ cell apoptosis.🪱

Learn more about this #GENETICS study from the @rogerdjp.bsky.social lab: buff.ly/21pVeb6

23.05.2025 22:02 — 👍 1    🔁 1    💬 0    📌 0

Check out our new research published @genetics-gsa.bsky.social

09.05.2025 07:03 — 👍 4    🔁 0    💬 0    📌 0
Preview
Cell Biology of the Nervous System: Cellular Mechanisms of Communication The exploration of the cell biological aspects of nervous system development, function and health continues delivering groundbreaking pieces of information that push forward our understanding of brai…

I highly recommend attending this exciting EMBO workshop.

meetings.embo.org/event/25-cel...

28.02.2025 00:44 — 👍 4    🔁 1    💬 1    📌 1

@rogerdjp is following 20 prominent accounts