Takahiro Maeda

A beautiful review by Stu Orkin—a true giant in transcriptional regulation, hematopoiesis, and sickle cell research!

Mutations that stick: Unexpected discovery of molecular glue mimicry Recent elegant studies in Nature uncovered an unprecedented molecular glue-like mechanism of action for the preclinical drug UM171. This small molecule showed striking functional and structural similarities to brain-cancer mutations that prompt neomorphic protein interactions. This phenomenon of chemical-genetic convergence could be reverse-engineered to aid the rational design of induced proximity therapeutics.

Mutations that stick: Unexpected discovery of molecular glue mimicry

Healing My Family’s Future How genetics and IVF empowered a family to leave cancer behind.

A powerful story about familial cancers and one person's struggle with a genetic diagnosis before disease onset. Thanks to the author (Jennifer Lai Remmel) for sharing: press.asimov.com/articles/fam...

While on clinical service recently, I saw many children who were severely ill due to cancer, flu, and other causes. Sadly this move will mean that healthcare access for many children will be lost, as our institutions suffer from the loss of this critical support:
grants.nih.gov/grants/guide...

A new ‘mini-CRISPR' flexes its editing power in monkey muscles The downsized DNA-slicing machinery may reach more tissues to take aim at more diseases

A miniaturized #CRISPR system can edit DNA in monkey muscle, according to a new preprint.

So proud of @katie-maurer.bsky.social and Cameron Park for showing the power of combining innovative #ML with what we call "Katie Intelligence" (our domain expert in the loop 👩‍🔬) for building impactful computational tools and applying them to obtain unexpected clinical insight!

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

The starter pack that all leukemia people were waiting for! This is just a very basic pack, if you want to be included, leave a comment below!

go.bsky.app/EY3k2bE

Thanks for making this pack available. Great idea! Please add me to the list.