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Michael Galperin

@mygalperin.bsky.social

Lead Scientist at the Division of Intramural Research (formerly NCBI), NLM, NIH. Bacterial signaling, c-di-GMP, c-di-AMP, protein domains, COG database

26 Followers  |  47 Following  |  3 Posts  |  Joined: 01.09.2025  |  1.8463

Latest posts by mygalperin.bsky.social on Bluesky

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A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

Differential activation of cGAS in naked mole rats! An exciting addition to our understanding of species-specific mutations tailoring the cGAS-STING pathway in individual organisms

www.science.org/doi/10.1126/...

09.10.2025 18:40 โ€” ๐Ÿ‘ 10    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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All science arises only because of the shared broader community. I want to especially recognize Rotem Sorek @soreklab.bsky.social Aude Bernheim @audeber.bsky.social our collaborators and the many wonderful labs and scientists in the field bringing together human and bacterial antiviral research!

09.10.2025 16:44 โ€” ๐Ÿ‘ 7    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Blavatnik National Awards

Blavatnik National Awards

Blavatnik National Awards

Blavatnik National Awards

Blavatnik National Awards

Blavatnik National Awards

Blavatnik National Awards

Blavatnik National Awards

Congratulations to Philip J. Kranzusch, Ph.D., Professor of Cancer Immunology and Virology, who was one of three scientists awarded top honors at the 2025 Blavatnik National Awards for Young Scientists.

Watch to learn more about his work: bit.ly/4pZUDkF

08.10.2025 17:05 โ€” ๐Ÿ‘ 30    ๐Ÿ” 9    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2
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The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.

Viral AlphaFold Database (VAD) is live in Science Advances

~27,000 predicted viral protein monomers & homodimers

Conserved folds across bacteria, archaea & eukaryotic viruses

New toxinโ€“antitoxin system KreTA uncovered

Vast โ€œfunctional darknessโ€ remains uncharted

www.science.org/doi/10.1126/...

02.10.2025 08:48 โ€” ๐Ÿ‘ 81    ๐Ÿ” 34    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing.
journals.asm.org/doi/10.1128/...
@asm.org

07.10.2025 20:32 โ€” ๐Ÿ‘ 23    ๐Ÿ” 8    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
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Dissimilar Reactions and Enzymes for Psilocybin Biosynthesis in Inocybe and Psilocybe Mushrooms Mushrooms have learned twice independently how to make the iconic magic mushroom natural product psilocybin. This article introduces the enzymes of the second pathway, found in a fiber cap mushroom. ....

Two fungal genera use two distinct pathways to synthesize psilocybin
onlinelibrary.wiley.com/doi/full/10....

06.10.2025 13:25 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...

01.10.2025 16:05 โ€” ๐Ÿ‘ 85    ๐Ÿ” 43    ๐Ÿ’ฌ 4    ๐Ÿ“Œ 0
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Descubren nuevos mecanismos que regulan la motilidad y transferencia de ADN en bacterias Investigaciones recientes realizadas por un equipo de cientรญficos en colaboraciรณn con diversas universidades y centros de investigaciรณn han revelado nuevos mecanismos que regulan la motilidad bacteria...

Also in Spanish ;-)

larepublica.es/2025/09/27/d...

30.09.2025 18:31 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Thrilled to be a coauthor in this story ๐Ÿš€ Check out our latest publication on the archaellum - spoiler: it's an archaellum in bacteria ๐Ÿ˜ฑ Who would have thought? Thank you to all the authors, and especially @sshamphavi.bsky.social for really keeping this paper rotating ๐Ÿ˜‰

17.09.2025 17:56 โ€” ๐Ÿ‘ 6    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social

17.09.2025 17:41 โ€” ๐Ÿ‘ 119    ๐Ÿ” 58    ๐Ÿ’ฌ 7    ๐Ÿ“Œ 8

And a major contribution from @vikramalva.bsky.social

19.09.2025 12:44 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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ComFB, a widespread family of c-di-NMP receptor proteins | PNAS Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofil...

And here is the published version of the work from @selimlab.bsky.social, @mygalperin.bsky.social, Dubnau labs and @thethormannden.bsky.social labs
(superb collaboration)

ComFB, a widespread family of c-di-NMP receptor proteins

www.pnas.org/doi/10.1073/...

19.09.2025 11:04 โ€” ๐Ÿ‘ 16    ๐Ÿ” 7    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
2026 Sensory Transduction in Microorganisms Conference GRC The 2026 Gordon Research Conference on Sensory Transduction in Microorganisms will be held in Ventura, California. Apply today to reserve your spot.

Registration is open! Come join us at the sensory transduction in microorganisms GRC! Spread the word! www.grc.org/sensory-tran...

12.09.2025 06:04 โ€” ๐Ÿ‘ 12    ๐Ÿ” 11    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
ASM Launches New Food Microbiology Journal ASM is launching ASM Food Microbiology, a new journal dedicated to advancing research on microbial safety, fermentation, spoilage and biotechnological innovations in food systems.

asm.org/press-releas...

11.09.2025 20:37 โ€” ๐Ÿ‘ 2    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Using bioinformatics for identifying and plugging metabolic pathway holes | PNAS Using bioinformatics for identifying and plugging metabolic pathway holes

Some thoughts on metabolism and metabolic pathway holes (PMID: 40892933)
pnas.org/doi/10.1073/....

02.09.2025 20:53 โ€” ๐Ÿ‘ 12    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Prioritising Microbiology in Secondary Education Addresses Emerging Scientificโ€Socialโ€Educational Challenges and Competency Needs This work highlights how microbiology education can empower secondary school students with critical and systems thinking, fostering STEM literacy, overcoming barriers and preparing informed, responsi...

Prioritising Microbiology in Secondary Education Addresses Emerging Scientific-Social-Educational Challenges and Competency Needs

#MicrobialBiotech by Lara Amorim, Conceiรงรฃo Santos, and Kenneth Timmis

enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

01.09.2025 09:44 โ€” ๐Ÿ‘ 5    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1

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