Butterfly-shaped pattern dystrophy complicated by retinal pigment epithelium tear – case report

European Journal of Ophthalmology, Ahead of Print.
IntroductionTo report a rare case of a 71-year-old male with bilateral butterfly-shaped pattern dystrophy (BPD) who developed a retinal pigment epith

Next generation sequencing in children with isolated congenital cataract

European Journal of Ophthalmology, Ahead of Print.
PurposeCongenital cataracts (CC) are a preventable cause of childhood blindness, accounting for approximately 10% of cases. A significant portion of CC cases remains idiopa

Clinicopathologic correlations and multimodal imaging of vitreoretinal metastasis from breast carcinoma

European Journal of Ophthalmology, Ahead of Print.
PurposeTo present a case of non-uveal intraocular metastatic disease originating from relapsed breast carcinoma.MethodsWe report a 67-year-ol

Safety and efficacy of MicroPulse transscleral laser therapy with the revised P3 delivery device: A randomized controlled trial

European Journal of Ophthalmology, Ahead of Print.
ObjectiveTo evaluate the safety and efficacy of MicroPulse Transscleral Laser Therapy (MicroPulse TLT) with the Revis

Analysing the translatability of macular hole size measurements between high-density horizontal and radial OCT scan patterns Objective To assess the interchangeability of minimum linear diameter (MLD) macular hole (MH) size measurements in high-density horizontal and radial scan modes in optical coherence tomography (OCT). Methods and analysis 60 patients with a MH had repeat high-density OCT volume scans in a horizontal (30 µm interscan-spacing) and a radial (angular 3.75° interscan-spacing) mode, and the MLD was measured by five raters. Results There were no significant differences in the MLD measurements within the horizontal and the radial modes across repeat measurements of each rater in volume scan 1 (all p≥0.14 and p≥0.28, respectively), between volume scans 1 and 2 (all p≥0.14 and p≥0.69), among the raters (p=0.70 and p=0.60), and using all MLD measurements obtained in this study between primary and repeat measurements in volume scan 1 (p=0.10 and p=0.74) and between measurements obtained in volume scan 1 and 2 (p=0.21 and p=0.90). There was a statistically significant difference of –10.05 µm between the mean MLD of all measurements in the horizontal (n=900) and in the radial (n=900) mode (427.91 (±187.01) vs 437.97 (±184.93) µm; p<0.001). However, the variability of these differences around the mean MLD was large (95% limits of agreement –77.31 to 57.21 µm). The mean difference between all horizontal and all radial MLD measurements in a MH was for MHs that had their widest MLD within 15° of the horizontal, vertical and diagonal meridians 0.77 (±13.88) µm, –34.43 (±55.22) µm and –10.39 (± 34.62) µm, respectively. Conclusions Horizontal scans systematically underestimate the maximum MLD if located vertically or diagonally; however, they have less intra-rater and inter-rater and inter-scan variability in MLD measurements as compared with radial scans. Therefore, the two scan modes are not interchangeable but rather complement each other. These results may be limited to the MLD range analysed (125–924 µm).

Analysing the translatability of macular hole size measurements between high-density horizontal and radial OCT scan patterns

Objective To assess the interchangeability of minimum linear diameter (MLD) macular hole (MH) size measurements in high-density horizontal and radial scan modes in optical

VIDEO: ‘Exciting’ uveitis pipeline includes oral, intravitreal and topical therapies

FORT LAUDERDALE, Fla. — In this Healio Video Perspective from the Retina World Congress, Dilraj S. Grewal, MD, FASRS, provides an update on the progress of therapies for noninfectio
www.healio.com/news/ophthal...

Not Just Another Pilocarpine

An in-depth look at the new Qlosi™ topical drop for presbyopia.
crstoday.com/articles/apr...

Oral zervimesine reduced GA lesion growth in phase 2 study from Cognition Therapeutics

Ophthalmology Times - ophthalmology news, articles, and events in a timely and accurate manner for members of the ophthalmic community.
www.ophthalmologytimes.com/view/oral-ze...

Results of phase 2 clinical SAGA study of oral gildeuretinol for GA presented at ARVO 2025

Alkeus Pharmaceuticals reveals promising Phase 2 SAGA study results, showing gildeuretinol slows vision decline in geographic atrophy linked to AMD.
www.ophthalmologytimes.com/view/results...

Innovent Biologics completes first patient dosing in its phase 2 clinical trial assessing efdamrofusp alfa in patients with DME

Innovent Biologics initiates phase 2 trial for efdamrofusp alfa, a promising treatment for diabetic macular edema, aiming to i
www.ophthalmologytimes.com/view/innoven...

Socioeconomic status linked with worse eye structure, function in glaucoma

SALT LAKE CITY — Lower socioeconomic status was linked with worse eye structure and function at initial presentation in patients undergoing selective laser trabeculoplasty, according to a pos
www.healio.com/news/ophthal...

Topcon Healthcare acquires RetInSight to zero in on AI monitoring of OCT images

Topcon Healthcare acquired RetInSight, an Austria-based company that develops AI-driven software for eye care professionals, according to a Topcon press release. RetInSight’s AI algorith
www.healio.com/news/optomet...

Beacon Therapeutics shares 6-month interim safety and efficacy results from Phase 2 DAWN study for XLRP

Beacon Therapeutics reveals promising interim results for laru-zova, a gene therapy showing potential to improve vision in XLRP patients.
www.ophthalmologytimes.com/view/beacon-...

Galimedix Therapeutics completes single ascending dose portion of phase 1 trial assessing GAL-101

Galimedix Therapeutics advances GAL-101, an oral therapy targeting Alzheimer’s and AMD, completing phase 1 SAD study with promising safety results.
www.ophthalmologytimes.com/view/galimed...

Assessment of AI-enabled screening for ROP in low-resource settings

Machine learning algorithms enhance retinopathy of prematurity screening using smartphone images, expanding access in low-resource settings and easing pediatric ophthalmologist workloads
www.ophthalmologytimes.com/view/assessm...

First patient dosed in VAN-2401 phase 1 clinical trial

The VAN-2401 phase 1 clinical trial will evaluate the use of KH658 for the treatment of wet AMD.
www.ophthalmologytimes.com/view/first-p...

Validation of artificial intelligence algorithm LuxIA for screening of diabetic retinopathy from a single 45{degrees} retinal colour fundus images: the CARDS study Objective This study validated the artificial intelligence (AI)-based algorithm LuxIA for screening more-than-mild diabetic retinopathy (mtmDR) from a single 45° colour fundus image of patients with diabetes mellitus (DM, type 1 or type 2) in Spain. Secondary objectives included validating LuxIA according to the International Clinical Diabetic Retinopathy (ICDR) classification and comparing its performance between different devices. Methods In this multicentre, cross-sectional study, retinal colour fundus images of adults (≥18 years) with DM were collected from five hospitals in Spain (December 2021–December 2022). 45° colour fundus photographs were captured using non-mydriatic Topcon and ZEISS cameras. The Discovery platform (RetinAI) was used to collect images. LuxIA output was an ordinal score (1–5), indicating a classification as mtmDR based on an ICDR severity score. Results 945 patients with DM were included; the mean (SD) age was 64.6 (13.5) years. The LuxIA algorithm detected mtmDR with a sensitivity and specificity of 97.1% and 94.8%, respectively. The area under the receiver-operating characteristic curve was 0.96, indicating a high test accuracy. The 95% CI data for overall accuracy (94.8% to 95.6%), sensitivity (96.8% to 98.2%) and specificity (94.3% to 95.1%) indicated robust estimations by LuxIA, which maintained a concordance of classification (N=829, kappa=0.837, p=0.001) when used to classify Topcon images. LuxIA validation on ZEISS-obtained images demonstrated high accuracy (90.6%), specificity (92.3%) and lower sensitivity (83.3%) as compared with Topcon-obtained images. Conclusions AI algorithms such as LuxIA are increasing testing feasibility for healthcare professionals in DR screening. This study validates the real-world utility of LuxIA for mtmDR screening.

Validation of artificial intelligence algorithm LuxIA for screening of diabetic retinopathy from a single 45{degrees} retinal colour fundus images: the CARDS study

Objective This study validated the artificial intelligence (AI)-based algorithm LuxIA for screening more-than-mild diabetic retinopat

Image Recognition Performance of GPT-4V(ision) and GPT-4o in Ophthalmology: Use of Images in Clinical Questions

Image Recognition Performance of GPT-4V(ision) and GPT-4o in Ophthalmology: Use of Images in Clinical Questions
www.dovepress.com/image-recogn...

Demographic and Clinical Factors Associated with Mechanisms of Open Globe Injury in the United States: A Multi-Center Study

This study provides important insights into which demographic and clinical factors put patients at risk for different mechanisms of OGIs.
www.dovepress.com/demographic-...

Prediction of perimetric progression in ocular hypertension and open angle glaucoma based on corneal biomechanics

European Journal of Ophthalmology, Ahead of Print.
PurposeTo identify parameters that are significant risk predictors of visual field (VF) progression in patients with ocular hyperte

Alcohol delamination and topical mitomycin-C 0.02% for the treatment of corneal intraepithelial neoplasia

European Journal of Ophthalmology, Ahead of Print.
PurposeTo report a case of a patient diagnosed with corneal intraepithelial neoplasia (CIN) with ocular discomfort and blurred vision, succ

Autologous corneal patch for simultaneous bilateral perforation in Sjögren's syndrome. A case report

European Journal of Ophthalmology, Ahead of Print.
PurposeTo present a case of simultaneous bilateral corneal perforation in a patient affected by Sjögren syndrome (SjS) successfully managed with

Analysis on the clinical correlation of lens parameters and choroidal thickness with the severity of primary angle closure disease

European Journal of Ophthalmology, Ahead of Print.
Purpose:The purpose of this study is to investigate the correlation of lens parameters and choroidal thickness (RC

Play, pressure, and pachychoroid: A case series on e-sports players

European Journal of Ophthalmology, Ahead of Print.
PurposeThe pachychoroid disease spectrum is characterized by choroidal thickening, vascular hyperpermeability, and structural alterations in the choroidal circulation. This can

Evaluation of the macula pigment optical density by a psychophysical test in dry age-related macular degeneration

European Journal of Ophthalmology, Ahead of Print.
PurposeTo evaluate the macular pigment optical density (MPOD) in dry age-related macular degeneration (AMD).MethodsThis prospective

Multimodal imaging and functional outcomes of choroidal metastases from non-small cell lung cancer treated with targeted therapy

European Journal of Ophthalmology, Ahead of Print.
PurposeTo evaluate the long-term outcomes of next-generation tyrosine kinase inhibitor (TKI) therapy in patients wit

ASCRS 2025: Mark Lobanoff, MD, on making the move to office-based surgery

Exploring how oral sedation and office-based surgery can enhance efficiency and patient experience
www.ophthalmologytimes.com/view/ascrs-2...

Association between leukocyte telomere length and incident glaucoma: A prospective UK biobank study

Eye, Published online: 07 May 2025; doi:10.1038/s41433-025-03838-7Association between leukocyte telomere length and incident glaucoma: A prospective UK biobank study
www.nature.com/articles/s41...

ARVO 2025: Barsha Lal, PhD, presents an atropine study that addresses families' accomodative concerns

A one-drop, low dose atropine study assesses accommodative amplitude and dynamics, with clinically applicable findings.
www.ophthalmologytimes.com/view/arvo-20...

Phase 2 data on IBI302 announced by Innovent Biologics

Ophthalmology Times - ophthalmology news, articles, and events in a timely and accurate manner for members of the ophthalmic community.
www.ophthalmologytimes.com/view/phase-2...