The Lancet Diabetes & Endocrinology

The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia.

Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia www.thelancet.com/journals/lan...
#prediabetes #remission

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As screening and early treatment for type 1 #diabetes become more widespread, the European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) consortium highlights the need for clearer, more consistent terminology www.thelancet.com/journals/lan... #T1D

Type 2 diabetes subtypes classification: a global reckoning with heterogeneity For decades, type 2 diabetes has been managed as a monolithic condition, defined by hyperglycaemia and treated via uniform, stepwise algorithms. Although operationally convenient, this practice increa...

A syndromic framework grounded in molecular pathophysiology could ultimately reorient #diabetes care towards precise, stratified risk prediction, personalised prevention, and targeted therapy www.thelancet.com/journals/lan... #T2D
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Figure showing effects of incretins on digestion and the possible resulting clinical benefits. Copyright: 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Incretin-based therapies are becoming a core component of diabetes care.

By linking digestion, metabolism, & cardiovascular function, incretin-based therapies can help reduce morbidity & mortality.

Find out more in @thelancetendo.bsky.social: tinyurl.com/dvtv7j28

Experience evolves into evidence in the new MEN1 guidelines Nearly a quarter of a century has passed since the publication of the first clinical practice guideline on multiple endocrine neoplasia type 1 (MEN1) in 2001, which followed the identification of the ...

Joint Linked Comment by Adrian F Daly:
Experience evolves into evidence in the new MEN1 guidelines thelancet.com/journals/lan...
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Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis In patients with MEN1, subtotal parathyroidectomy achieved greater reductions in persistence and recurrence of primary hyperparathyroidism than less than subtotal parathyroidectomy; for non-functionin...

Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis thelancet.com/journals/lan...
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Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice Multiple endocrine neoplasia type 1 (MEN1) is characterised by combined occurrence of parathyroid tumours, duodenopancreatic neuroendocrine tumours, and anterior pituitary adenomas. Some patients migh...

Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice thelancet.com/journals/lan...
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Glucocorticoid-induced osteoporosis: novel concepts and clinical implications Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

Fragility fractures remain a common & serious
complication of long-term oral glucocorticoid therapy
that can affect all skeletal sites although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
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Peripheral CB1 receptor blockade for treatment of obesity The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1 CB1 receptors are abundan...

Kishore M Gadde & colleagues comment on:
Peripheral CB1 receptor blockade for treatment of obesity www.thelancet.com/journals/lan...
#monlunabant #obesity #metabolic #syndrome

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The implications of this trial, combined with existing evidence, suggest that #monlunabant has potential as a novel treatment option for people with #obesity and #metabolic #syndrome, if a safe and effective therapeutic window can be established www.thelancet.com/journals/lan...

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The evolutionary basis for type 2 #diabetes prevalence in the Arabian Peninsula www.thelancet.com/journals/lan... #T2D

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Prolactin-secreting adenomas: pathogenesis, diagnosis, and management Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as prolactin-secreting pituitary adenomas and other pituitary stalk-compressing masses...

#Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as #prolactin-secreting #pituitary #adenomas and other pituitary stalk-compressing masses
www.thelancet.com/journals/lan...
#prolactinomas

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The unique signature of tyrosine kinase inhibitor-induced hypothyroidism Tyrosine kinase inhibitors (TKIs) are anti-cancer agents that inhibit the activity of oncogenic protein kinases. Thyroid hormone abnormalities are common during treatment with TKIs, typically manifest...

As the targets of tyrosine kinase inhibitors (#TKIs) also have roles in many physiological processes, TKIs can cause multiple treatment-related adverse events, among which an increase in serum #thyroid stimulating hormone (TSH) concentrations frequently occurs www.thelancet.com/journals/lan... .

A promotional card for the 2025 EAT-Lancet Commission, officially launching on October 3 at Stockholm Food Forum.

Tune in on October 3rd for the official launch of the 2025 EAT-Lancet Commission. A major update to the science and what it means for our global food system.

🔗 Register for the livestream here: bit.ly/3Kg9SW8

Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlle... In young people with recent-onset, clinical type 1 diabetes, 2·5 mg/kg and 0·5 mg/kg ATG reduced loss of β-cell function, showing the potential of an affordable, repurposed agent, ATG, in a low and sa...

Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial tinyurl.com/bdenbtyb

The gut–bone axis: implications of gut hormone-based therapies for bone health Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel increases in serious and potentially fatal comorbidities, particularly type 2 dia...

The gut–bone axis: implications of gut hormone-based therapies for bone health thelancet.com/journals/lan...
#GLP-1 #GIP #incretins #weightloss #obesity #overweight #Bonehealth #osteoporosis

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Peripheral CB1 receptor blockade for treatment of obesity The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1 CB1 receptors are abundan...

Also read the Linked Comment:
Peripheral CB1 receptor blockade for treatment of obesity thelancet.com/journals/lan...
#obesity #MetabolicSyndrome

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Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial Participants receiving monlunabant showed statistically significant and clinically meaningful weight loss compared with those receiving placebo for all tested doses. Only slightly greater weight loss ...

New—Efficacy and safety of #monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial thelancet.com/journals/lan...
#obesity #MetabolicSyndrome

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High cumulative doses of exogenous #glucocorticoids lead to a spectrum of side-effects, in particular increased #fracture risk. Fragility fractures might result in immobility, frequent admission to hospitals, and loss of quality of life thelancet.com/journals/lan...
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World Heart Day: diabetes and cardiovascular risk Cardiovascular disease is one of the leading causes of death globally. Tragically, as many as 80% of heart disease and stroke cases could be avoided through prevention. For people with diabetes, the r...

New Editorial:
World Heart Day: diabetes and cardiovascular risk www.thelancet.com/journals/lan...
#diabetes #CVD
#WorldHeartDay
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Bone health in adults with obesity before and after interventions to promote weight loss Obesity and its associated comorbidities constitute a serious and growing public health burden. Fractures affect a substantial proportion of people with obesity and result from reduced bone strength r...

#Fractures affect a substantial proportion of people with #obesity and result from reduced #bone strength relative to increased mechanical loading, together with an increased risk of #falls www.thelancet.com/journals/lan...
#weightloss #BariatricSurgery #GLP-1 receptor agonists

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Classifying a distinct form of diabetes in lean individuals with a history of undernutrition: an international consensus statement Since 1955, a form of diabetes in lean, young (BMI <18·5 kg/m2, age <30 years) individuals with a history suggestive of undernutrition from before birth and throughout childhood has been described in ...

Published in @lancetgh.bsky.social
Classifying a distinct form of #diabetes in lean individuals with a history of undernutrition: an international consensus statement www.thelancet.com/journals/lan...
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Glucocorticoid-induced osteoporosis: novel concepts and clinical implications Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay in the management of various immune-mediated diseases. High cumulative doses of exogenous glucocorticoids lead...

Fragility #fractures remain a common and serious
complication of long-term oral #glucocorticoid therapy
that might affect all skeletal sites, although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess

#EndoSky

Sporadic #prolactinomas are the most common functioning #pituitary #adenomas, with a female predominance during reproductive years. In men, these adenomas are usually larger and more aggressive www.thelancet.com/journals/lan...
#hyperprolactinaemia

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Figure: Global age-specific cancer (A) incidence and (B) mortality in 2023 for all sexes combined. Results are presented by 5-year age group. Left panels present age-specific incidence and mortality rates. Right panels present age-specific new case and death proportions. Copyright: 2025 Elsevier Ltd. All rights are reserved.

Cancer deaths expected to rise to over 18 million in 2050—an increase of nearly 75% from 2024, study forecasts.

Explore the data ▶️ tinyurl.com/5n7dfnws @ihmeuw.bsky.social #NCDs

International Federation for the Surgery of Obesity statement on metabolic bariatric surgery after pharmacotherapy-induced weight loss in clinical obesity Clinical obesity is a chronic systemic disease characterised by alterations in the function of tissues, organs, physical ability, or a combination of these due to excess adiposity, which can increase ...

International Federation for the Surgery of Obesity statement on metabolic bariatric surgery after pharmacotherapy-induced weight loss in clinical obesity www.thelancet.com/journals/lan...
#obesity
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Rethinking obesity through the lens of genetics, environment and differential life circumstances As weight loss solutions continue to proliferate, the enduring debate over whether obesity stems from personal responsibility or broader environmental influences is once again drawing attention. Many ...

As weight loss solutions continue to proliferate, the enduring debate over whether obesity stems from personal responsibility or broader environmental influences is once again drawing attention thelancet.com/journals/lan...
#weightloss #obesity

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Revisiting malnutrition-related diabetes Malnutrition-related diabetes has drifted in and out of global diabetes classification over the past 40 years.1,2 It was removed from WHO diabetes classification in 1999,2 but in 2025, it was again fo...

Malnutrition-related #diabetes, rather than being an outlier, might simply represent one extreme of a wider biological spectrum—its persistence reflecting the ongoing clinical need that sustains its relevance www.thelancet.com/journals/lan...

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As screening and early treatment for type 1 #diabetes become more widespread, the European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) consortium highlights the need for clearer, more consistent terminology www.thelancet.com/journals/lan...
#T1D

The ongoing global epidemic of #MASLD & its close pathogenic & predictive relationship with the non-communicable diseases of #cardiovascular disease, #cancer, #obesity & type 2 #diabetes, allow the inclusion of #MASLD as a new non-communicable disease
www.thelancet.com/journals/lan...
#OpenAccess