Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma | NEJM In this first-in-human, investigator-initiated, open-label study, three participants with recurrent glioblastoma were treated with CARv3-TEAM-E T cells, which are chimeric antigen receptor (CAR) T ...

Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma | New England Journal of Medicine www.nejm.org/doi/full/10....

Thermal Tracks: A Gaussian process-based framework for universal melting curve analysis enabling unconstrained hit identification in thermal proteome profiling experiments Thermal Tracks is a Python-based statistical framework for analyzing protein thermal stability data that overcomes key limitations of existing thermal proteome profiling (TPP) work-flows. Unlike stand...

For those who perform thermal proteome profiling (TPP) experiments, you might find this new data analysis approach (and open source Python software) useful. Developed by postdoc @jfhevler.bsky.social 🙏

arxiv.org/abs/2508.096...

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects - Nature Communications The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin remodeling, DNA repair, and cell cycle progression.

www.nature.com/articles/s41...

Covariation MS uncovers a protein that controls cysteine catabolism - Nature A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

Covariation MS uncovers a protein that controls cysteine catabolism | Nature share.google/d4HSSGR7N7ky...

Principles of cotranslational mitochondrial protein import Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human cells are imported during translation on cytosolic ribosomes. Cotranslational import requires an N-terminal pres...

www.cell.com/cell/fulltex...

Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL While targeting glucose metabolism shows potential in cancer therapy, its clinical implications remain unclear. This study finds that low-carbohydrate diets or impaired glucose metabolism in cancer ce...

www.cell.com/cell/abstrac...

Glucose restriction: double edged sword in cancer treatment Glucose restriction generally limits tumor growth. Recently, Wu et al. reported that glucose restriction inhibits primary tumors but promotes lung metastasis by forming a macrophage-dominated, natural...

Glucose restriction: double edged sword in cancer treatment: Trends in Cancer www.cell.com/trends/cance...

As much as we like linear and simple scenarios, it is never that simple...

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Fluctuating DNA methylation tracks cancer evolution at clinical scale | Nature share.google/ax6OqO2Pk2Ye...

WSTF nuclear autophagy regulates chronic but not acute inflammation - Nature During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent...

www.nature.com/articles/s41...

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics Single-cell metabolomics (SCM) can probe metabolic heterogeneity but is hindered by low sensitivity for small molecules, limited scalability, and the lack of standardized frameworks for data analysis....

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial - Nature Medicine A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells followin...

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial | Nature Medicine share.google/BIdr3Vwfk5ZB...

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation Development of LOV-domain-controlled ligase for translation localization (LOCL-TL), an optogenetic approach for monitoring translation with codon resolution at any defined subcellular location under p...

Proximity-specific ribosome profiling reveals the logic of localized mitochondrial translation: Cell share.google/QdV91fkKL3dR...

Human progenitor T-cell differentiation regulated by the mechanical resistance of thymus-mimetic extracellular matrices Therapeutic T-cell engineering ex vivo from human hematopoietic stem cells (HSCs) focuses on recapitulating notch1-signaling and α4β1-integrin-mediated adhesion within the thymic niche with supportive...

www.biorxiv.org/content/10.1...

www.jci.org/articles/vie...

inTRACKtive: a web-based tool for interactive cell tracking visualization - Nature Methods Nature Methods - inTRACKtive: a web-based tool for interactive cell tracking visualization

inTRACKtive: a web-based tool for interactive cell tracking visualization | Nature Methods share.google/eILiwsisCwBQ...

An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification - Nature Communications Thymic epithelial cells (TECs) are essential for T cell development but how they develop from progenitors in humans is difficult to study. Here authors set up an in vitro system for thymus organogenes...

www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

www.nature.com/articles/s41...

TMEM65 functions as the mitochondrial Na+/Ca2+ exchanger - Nature Cell Biology Zhang, Chang et al. identify the protein TMEM65 as the mitochondrial Na+/Ca2+ exchanger, showing that it dimerizes to mediate ion transport and contains a binding site for a well-known inhibitor of mi...

www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis

Congrats to @sancholab.bsky.social and his team!

Proteomic characterization of type I collagen N-terminal crosslinked peptides Collagen cross-links mediated by the lysyl oxidase and lysyl hydroxylase families of enzymes significantly contribute to the biomechanical strength an…

www.sciencedirect.com/science/arti...

Full list of Democrats who voted to block new Trump impeachment articles Nearly 130 House Democrats on Tuesday voted to table Representative Al Green's articles of impeachment against Trump.

Democrats???
www.newsweek.com/donald-trump...

Repurposing salicylic acid as a versatile inducer of proximity - Nature Chemical Biology A highly compact chemically induced proximity system dependent on salicylic acid or aspirin enables control of biological processes and cellular therapeutics using an over-the-counter drug with minima...

www.nature.com/articles/s41...

Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment - Nature Communications Zaza and colleagues demonstrate that DNA-PAINT on a spinning disk confocal microscope with optical photon reassignment enables high-resolution imaging across large fields and imaging depths, resolving...

www.nature.com/articles/s41...

Mitochondrial presequences harbor variable strengths to maintain organellar function Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack ...

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵

www.biorxiv.org/content/10.1...

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

www.science.org/doi/10.1126/...

Fascinating study from @miriammerad.bsky.social ’s lab suggests our aging immune system may drive cancer. With age, bone marrow–derived monocyte-lineage cells replace resident lung myeloid cells — fueling tumor growth via IL-1 secretion.

👉https://www.science.org/doi/10.1126/science.adn0327

Unlocking in vivo metabolic insights with vibrational microscopy - Nature Methods Advances in cellular physiology research have created the need to visualize metabolic processes in both time and space. Vibrational microscopy has emerged as a promising method at the forefront of thi...

www.nature.com/articles/s41...

Spatial regulation of mitochondrial membrane potential by 𝛂5ꞵ1 integrin engagement in collective cell migration The mechanistic links between mechanical forces and bioenergetics remain elusive. We report an increase in mitochondrial membrane potential (MMP) along the leading row of collectively migrating Xenopu...

Spatial regulation of mitochondrial membrane potential by 𝛂5ꞵ1 integrin engagement in collective cell migration

journals.biologists.com/jcs/article/...

Loss of RET-ROS at complex I induces diastolic dysfunction in mice that is reversed by aerobic exercise - PubMed Central to the development of heart failure with preserved ejection fraction (HFpEF) is the redox disruption of metabolic processes, however, the underlying mechanisms are not fully understood. This s...

pubmed.ncbi.nlm.nih.gov/40327410/