Vern Dolinsky

We’re honoured to welcome the Dr. Heather Dean Lectureship speaker Dr. Lindsay Crowshoe from @ucalgary.bsky.social to the DREAM Symposium! The presentation will be hybrid; contact dream@chrim.ca for the Zoom link. Deadline to register is Nov 10! tinyurl.com/5d6em33b @chrimanitoba.bsky.social

The 14th Annual DREAM Symposium and DREAM Trainee Day are only days away! We have a great day planned. Don't miss this! Registration closes tonight! tinyurl.com/5d6em33b contact dream@chrim.ca #Diabetes #Research #Symposium @chrimanitoba.bsky.social @um-radyfhs.bsky.social

Maternal Obesity Programs Glucose Intolerance in Pregnant Female Offspring Maternal obesity is a known risk factor for metabolic dysfunction in offspring; however, its effect on metabolism during pregnancy in female offspring rema

Maternal #Obesity Programs Transgenerational Glucose Intolerance in Pregnant Female Offspring #DOHaD #diabetes @dream-diabetes.bsky.social diabetesjournals.org/diabetes/art...

Systematic REVIEW: GLP-1 agonist therapy for gestational #diabetes journals.lww.com/md-journal/f...

Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism Nature Metabolism - By developing a method that allows detection of transient, low-abundance acyl-CoA species, Liu et al. provide a thorough characterization of coenzyme A dynamics and subcellular...

Cellular acyl-CoA profiling reveals SLC25A42/SLC25A16 in #mitochondria import and #metabolism @natmetabolism.nature.com rdcu.be/eN5N4

Association of Maternal Prepregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood Objective This study aimed to evaluate associations of maternal prepregnancy BMI with offspring BMI and blood pressure in childhood, specifically for infants born preterm. Methods In this observat...

From the ECHO Cohort Study (n=13,810) Association of Maternal Pre- #pregnancy BMI With Offspring Cardiometabolic Outcomes in Childhood #DOHaD #obesity @dream-diabetes.bsky.social @dohadcanada.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

Discover MyRoad, a platform supported by CIHR, offering research training & mentorship in #obesity, #diabetes & #cardiometabolic #diseases. New opportunities this fall include cohort training, travel awards & more. 🎓✈️
Learn more: www.myroadplatform.ca/en
Contact: MyRoad.MaRoute@criucpq.ulaval.ca

Looking forward to the 14th Annual DREAM Symposium will be on Nov 13, 2025, and the DREAM Trainee Day will be Nov 12. Free to Register Here! tinyurl.com/5d6em33b #Diabetes #Research #Symposium @chrimanitoba.bsky.social @um-radyfhs.bsky.social

Introducing the second keynote speaker of the DREAM #Symposium: Making Connections for Innovation, Dr. Lorraine Lipscombe from @utoronto.ca! Mark your calendars for Nov 13📅 Register here: tinyurl.com/5d6em33b @chrimanitoba.bsky.social @um-radyfhs.bsky.social @nhp-uoft.bsky.social #Diabetes #Research

We’re excited to announce our third keynote speaker for the 2025 DREAM #Symposium: Dr. Barry Lavallee, Chief Executive Officer of Keewatinohk Inniniw Minoayawin Inc.! Don't miss this event! Register here: tinyurl.com/5d6em33b @chrimanitoba.bsky.social @um-radyfhs.bsky.social #Diabetes #Research

YouTube video by T2D Network Empowering Diabetes Care Integrating Health Information

I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...

Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches Human T2D beta cell function was restored, the rescuing mechanisms disentangled, and hits identified to promote T2D remission.

Functional recovery of islet β cells in human type 2 #diabetes: Transcriptome signatures unveil therapeutic approaches @dream-diabetes.bsky.social @chrisadoucette.bsky.social www.science.org/doi/10.1126/...

From the HAPO study (n=112) : From Mothers With Hyperglycemia in Pregnancy 19 cord blood DNA Methylation CpG Predict Offspring beta cell dysfunction at ages 7, 11 and 18 #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social @adapubs.bsky.social diabetesjournals.org/diabetes/art...

Glucagon-Like Peptide-1 Receptor Agonists and Youth Obesity This Viewpoint discusses the use of glucagon-like peptide-1 receptor agonist treatments for weight management in youth.

🚨New in JAMA Pediatrics: Edmondson, Shah & Gregory discuss the promise & challenges of using GLP-1 receptor agonists for youth obesity. From safety concerns to access barriers, the piece highlights key unanswered questions for care & policy. 📖👇
jamanetwork.com/journals/jam... #obesity #youth #GLP1

Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques Scientific Reports - Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques

Transcriptomics reveals that Maternal western diet has a lasting impact of dysregulated #metabolism and RNA processing #genes in the skeletal muscles of Japanese Macaque offspring #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social

rdcu.be/eCbj2

Metabolomic and transcriptomic remodeling of bone marrow myeloid cells in response to maternal #obesity #DOHaD @dream-diabetes.bsky.social @dohadcanada.bsky.social journals.physiology.org/doi/full/10....

Parental obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction | American Journal of Physiology-Heart and Circulatory Phy... Acute myocardial infarction (MI) is a leading cause of death worldwide, accounting for >1 million deaths/year in the United States alone. Although parental obesity is a risk factor for offspring cardi...

Parental #obesity predisposes male and female offspring to exacerbated cardiac dysfunction and increased mortality after myocardial infarction #DOHaD @dohadcanada.bsky.social @dream-diabetes.bsky.social journals.physiology.org/doi/full/10....

Wow! check this out: #Proteomic profiling from pregnant human islets donors reveals the adaptations of the human endocrine pancreas to #pregnancy @nature.com pmc.ncbi.nlm.nih.gov/articles/PMC...

REVIEW: Role of #mitochondrial function in the pathogenesis of #diabetes @dream-diabetes.bsky.social

frontiersin.org/journals/end...

UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines Nature Communications - The relationship between pancreatic β-cell dysfunction and autoinflammation in T2DM is unclear. Here, the authors show the key role of a UCP2/mtDNA/STING axis in the...

UCP2 inhibition eliminates pancreatic beta cell autoinflammation in type 2 #diabetes with MitoG: An #islet #mitochondria targeting nanomedicine @chrisadoucette.bsky.social @dream-diabetes.bsky.social @nature.com
rdcu.be/eAfT2

The protein deacetylase SIRT2 exerts #metabolic control over adaptive β cell proliferation @dream-diabetes.bsky.social @jclinical-invest.bsky.social www.jci.org/articles/vie...

I'm really looking forward to this presentation!

🎉 Congratulations to all the researchers awarded funding through @chrimanitoba.bsky.social! Special shout out to DREAM researchers Drs. @verndolinsky.bsky.social, @thompsonisletlab.bsky.social, @chrisadoucette.bsky.social, and Lucy Marzban! 👏 Explore the funded projects: www.chrim.ca/fundedprojec...

Happening TODAY! Join the DREAM Trainees in 500 JBRC from 12 - 1 p.m., where Corey Sanderson (Doucette lab) and Caitlin Menzies (@verndolinsky.bsky.social lab) will share insights into their research methods. Don’t miss it! 🔬🧬 @chrimanitoba.bsky.social #diabetes #research #mice #betacell #t2d

DREAM team photos at the annual @chrimanitoba.bsky.social Summer Picnic ☀️🌭A perfect summer day spent with even better people! 😎

How does the density of the inner #mitochondrial membrane influence mitochondrial performance? Read this REVIEW if you are interested in learning more about the nexus between mito structure and function @dream-diabetes.bsky.social journals.physiology.org/doi/full/10....

Following the great @dream-diabetes.bsky.social presentation today about #mitochondria respirometry by Khushali Trivedi and Floriane Houenagnon, you can dig deeper and read about multifaceted mitochondria in all its diversity and complexity in this great review: pmc.ncbi.nlm.nih.gov/articles/PMC...

Dr. Chris Pascoe

As wildfires continue to burn across Manitoba, many families are trying to protect themselves from the smoke in the air.

In our latest blog, CHRIM investigator Dr. Chris Pascoe explains the health risks associated with wildfire smoke and how to keep safe.

Read it here: tinyurl.com/knjjyj97

On June 4, 2025, DREAM Trainees Khushali Trivedi and Caitlin Menzies presented their research at the Canadian Society of Pharmacology and Therapeutics Conference, and Khushali received the Ken Piafsky Award for her excellent presentation. Congratulations! So proud of our trainees 🎉👏 #CSPT25

📅 Mark your calendars! The 14th Annual DREAM Symposium will be on Nov 13, 2025, and the DREAM Trainee Day will be Nov 12. Abstracts due Sept 12. More info and abstract guidelines: tinyurl.com/yecf3ave 🔗Register here! tinyurl.com/5d6em33b #Diabetes #Research #Symposium @chrimanitoba.bsky.social