Systems consolidation reorganizes hippocampal engram circuitry
Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...
Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.
rdcu.be/el18q
A short thread follows for those interested.
1/n
14.05.2025 16:32 β π 220 π 98 π¬ 15 π 6
A woman in a burnt orange t-shirt shows off a wall garden to a family of onlookers.
A woman in a pink t-shirt shows off a large toothed fossil of a young girl.
A woman wearing a mask and a pink t-shirt explains about a small fossil jaw sheβs holding to two young boys and two young girls.
Three people sit on a stage having an animated discussion beneath a sign reading βAustin Film Society.β
The Texas Science Festival began on Friday & weβve already had fantastic fun at some exceptional events.
Weβve got lots more in the works, including 2 events tonight and 3 tomorrow.
Check out the full schedule at sciencefest.utexas.edu/events
#TexasScience #TexasScienceFestival #UTAustin
24.02.2025 20:19 β π 5 π 1 π¬ 0 π 0
The snRNA-seq turns up some interesting candidate genes that could mediate extinction-induced suppression of fear cells, e.g.:
14.06.2024 18:05 β π 1 π 0 π¬ 0 π 0
Next, we used snRNA-seq to show that extinction training markedly changes transcription patterns in DG granule cells that encode a fear memory, and that cells activated during recall of fear and recall of extinction have distinct transcriptomic profiles.
14.06.2024 18:02 β π 1 π 0 π¬ 1 π 0
We confirm that extinction suppresses reactivation of fear engram cells in dorsal and ventral dentate gyrus. We find that this suppression also occurs in dorsal CA1 but --interestingly-- not in ventral CA1. Perhaps vCA1 maintains a fear representation that is resistant to extinction?
14.06.2024 18:01 β π 1 π 0 π¬ 1 π 0
https://rdcu.be/dKOrk
Excited that our paper with Hans Hofmann's lab is out!
Extinction training suppresses activity of fear memory ensembles across the hippocampus and alters transcriptomes of fear-encoding cells: t.co/K8d4jAhiKS
14.06.2024 17:50 β π 15 π 2 π¬ 1 π 0
Response sub-additivity and variability quenching in visual cortex
Nature Reviews Neuroscience - Sub-additive responses to simultaneously presented stimuli and quenching of variability in responses to repeated presentations of a stimulus are characteristics of...
Why do sublinear response summation and quenching of shared variability tend to co-occur in cortex? We review phenomenological, normative, and circuit explanations. With Robbe Goris, Ruben Coen-Cagli, Nick Priebe, & Mate Lengyel. rdcu.be/dy1q5
π§ͺ #neuroskyence
20.02.2024 04:40 β π 19 π 9 π¬ 1 π 0
Find Out Why Health Insurance Denied Your Claim
You likely have the right to access records that explain why your insurer denied your claim or prior authorization request. Use ProPublicaβs free tool to generate a letter requesting your claim file...
Having health insurance in the US means that you now have a part-time job haggling with your insurance company & advocating for your own healthcare. To that end, here's a tool that can help with filing claims to contest denial of coverage, created by the nonprofit newsroom @propublica.bsky.social
09.11.2023 13:05 β π 186 π 96 π¬ 3 π 8
#Pavlovian2024 will be held from September 26-28 in Indianapolis! If you are interested in organizing a symposium, please complete this form: forms.gle/4QNv1TGBeHuf... Proposals are due 1/26/24 at 5 pm ET. Proposed speakers should be confirmed at time of submission. pavlovian.org
17.11.2023 14:45 β π 3 π 4 π¬ 0 π 0
Iβm so sad itβs over. That journal taxonomy was one of the funniest things Iβve ever read
06.10.2023 03:55 β π 2 π 0 π¬ 0 π 0
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