Michael Drew's Avatar

Michael Drew

@michaeldrew.bsky.social

1,159 Followers  |  470 Following  |  5 Posts  |  Joined: 04.10.2023  |  2.0339

Latest posts by michaeldrew.bsky.social on Bluesky

Preview
Systems consolidation reorganizes hippocampal engram circuitry Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

1/n

14.05.2025 16:32 β€” πŸ‘ 220    πŸ” 98    πŸ’¬ 15    πŸ“Œ 6
A woman in a burnt orange t-shirt shows off a wall garden to a family of onlookers.

A woman in a burnt orange t-shirt shows off a wall garden to a family of onlookers.

A woman in a pink t-shirt shows off a large toothed fossil of a young girl.

A woman in a pink t-shirt shows off a large toothed fossil of a young girl.

A woman wearing a mask and a pink t-shirt explains about a small fossil jaw she’s holding to two young boys and two young girls.

A woman wearing a mask and a pink t-shirt explains about a small fossil jaw she’s holding to two young boys and two young girls.

Three people sit on a stage having an animated discussion beneath a sign reading β€œAustin Film Society.”

Three people sit on a stage having an animated discussion beneath a sign reading β€œAustin Film Society.”

The Texas Science Festival began on Friday & we’ve already had fantastic fun at some exceptional events.

We’ve got lots more in the works, including 2 events tonight and 3 tomorrow.

Check out the full schedule at sciencefest.utexas.edu/events

#TexasScience #TexasScienceFestival #UTAustin

24.02.2025 20:19 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Post image Post image Post image Post image

Registration & Abstract Submission is open for the 2025 "Engram and Ensembles in Learning and Memory" meeting, at Trinity College Dublin in May.

Abstract deadline February 14.

#EngramsandEnsembles2025

Preliminary Agenda at event website:
event.fourwaves.com/engramsensem...

22.11.2024 15:38 β€” πŸ‘ 41    πŸ” 24    πŸ’¬ 0    πŸ“Œ 2
Post image

The snRNA-seq turns up some interesting candidate genes that could mediate extinction-induced suppression of fear cells, e.g.:

14.06.2024 18:05 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Next, we used snRNA-seq to show that extinction training markedly changes transcription patterns in DG granule cells that encode a fear memory, and that cells activated during recall of fear and recall of extinction have distinct transcriptomic profiles.

14.06.2024 18:02 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

We confirm that extinction suppresses reactivation of fear engram cells in dorsal and ventral dentate gyrus. We find that this suppression also occurs in dorsal CA1 but --interestingly-- not in ventral CA1. Perhaps vCA1 maintains a fear representation that is resistant to extinction?

14.06.2024 18:01 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
https://rdcu.be/dKOrk

Excited that our paper with Hans Hofmann's lab is out!
Extinction training suppresses activity of fear memory ensembles across the hippocampus and alters transcriptomes of fear-encoding cells: t.co/K8d4jAhiKS

14.06.2024 17:50 β€” πŸ‘ 15    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
Preview
Response sub-additivity and variability quenching in visual cortex Nature Reviews Neuroscience - Sub-additive responses to simultaneously presented stimuli and quenching of variability in responses to repeated presentations of a stimulus are characteristics of...

Why do sublinear response summation and quenching of shared variability tend to co-occur in cortex? We review phenomenological, normative, and circuit explanations. With Robbe Goris, Ruben Coen-Cagli, Nick Priebe, & Mate Lengyel. rdcu.be/dy1q5
πŸ§ͺ #neuroskyence

20.02.2024 04:40 β€” πŸ‘ 19    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0
Preview
Find Out Why Health Insurance Denied Your Claim You likely have the right to access records that explain why your insurer denied your claim or prior authorization request. Use ProPublica’s free tool to generate a letter requesting your claim file...

Having health insurance in the US means that you now have a part-time job haggling with your insurance company & advocating for your own healthcare. To that end, here's a tool that can help with filing claims to contest denial of coverage, created by the nonprofit newsroom @propublica.bsky.social

09.11.2023 13:05 β€” πŸ‘ 186    πŸ” 96    πŸ’¬ 3    πŸ“Œ 8
Post image

#Pavlovian2024 will be held from September 26-28 in Indianapolis! If you are interested in organizing a symposium, please complete this form: forms.gle/4QNv1TGBeHuf... Proposals are due 1/26/24 at 5 pm ET. Proposed speakers should be confirmed at time of submission. pavlovian.org

17.11.2023 14:45 β€” πŸ‘ 3    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

I’m so sad it’s over. That journal taxonomy was one of the funniest things I’ve ever read

06.10.2023 03:55 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

@michaeldrew is following 20 prominent accounts